Micro-CT detection of microstructure changes of alveolar bone in rats with diabetes induced by streptozotocin

YI Zixin; YI Ting; YAO Xinyu; ZHU Beibei; BEN Yali; ZHANG Wen

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Micro-CT detection of microstructure changes of alveolar bone in rats with diabetes induced by streptozotocin

更新时间：2023-04-14

- Micro-CT detection of microstructure changes of alveolar bone in rats with diabetes induced by streptozotocin
- Journal of Southwest Medical University Vol. 44, Issue 2, Pages: 110-113(2021)
- 作者机构：
  
  江汉大学医学院口腔医学系
- 作者简介：
- 基金信息：
- DOI：
  CLC： R781.4;R587.2
- Published：2021，
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[1]易子欣,易婷,姚心雨,祝贝贝,贲亚琍,张雯.Micro-CT检测STZ诱导的糖尿病大鼠牙槽骨微结构改变[J].西南医科大学学报,2021,44(02):110-113.

YI Zixin, YI Ting, YAO Xinyu, et al. Micro-CT detection of microstructure changes of alveolar bone in rats with diabetes induced by streptozotocin. [J]. Journal of Southwest Medical University 44(2):110-113(2021)
[1]易子欣,易婷,姚心雨,祝贝贝,贲亚琍,张雯.Micro-CT检测STZ诱导的糖尿病大鼠牙槽骨微结构改变[J].西南医科大学学报,2021,44(02):110-113. DOI：

YI Zixin, YI Ting, YAO Xinyu, et al. Micro-CT detection of microstructure changes of alveolar bone in rats with diabetes induced by streptozotocin. [J]. Journal of Southwest Medical University 44(2):110-113(2021) DOI：

摘要

目的:通过Micro-CT观察糖尿病大鼠牙槽骨微结构的变化。方法:雄性SD大鼠随机分为2组:对照组（n=4）和STZ（糖尿病）组（n=4）。糖尿病组大鼠腹腔内注射55 mg/kg链脲佐菌素。饲养12周后处死大鼠

上颌骨Micro-CT扫描分析

并进行HE染色。结果:HE染色可见STZ组牙槽骨边缘吸收明显

牙周膜纤维排列紊乱

牙龈上皮有明显的炎症细胞浸润。STZ组相较正常对照组CEJ-ABC距离明显增加（P <0.05）。Micro-CT分析STZ组Tb.N值减小（P <0.01）

Tb.sp值增加（P <0.05）。Micro-CT图像三维重构后可见STZ组牙槽骨吸收。结论:STZ诱导的糖尿病大鼠牙槽骨组织损伤明显

Micro-CT技术呈现了牙周骨组织微结构改变。

Abstract

Objective:To investigate the microstructure changes of alveolar bone in diabetic rats by micro-CT.Methods:Male Sprague-Dawley rats were randomly divided into control group and diabetes group

with 4 rats ineach group. The rats in the diabetes group were given intraperitoneal injection of 55 mg/kg streptozotocin. The ratswere sacrificed after 12 weeks of feeding

and micro-CT scan and HE staining were performed for the maxillarybone.Results:HE staining showed marked absorption of the edge of alveolar bone

disordered arrangement of peri-odontal membrane fibers

and marked inflammatory ceils infiltration in the gingival epithelium in the diabetes group.Compared with the control group

the diabetes group had a significant increase in distance from the cemento-enameljunction to the alveolar bone crest（P < 0.05）. Micro-CT analysis showed a significant reduction in Tb.N value（P <0.01） and a significant increase in Tb.sp value in the diabetes group（P < 0.05）. Micro-CT three-dimensional imagereconstruction showed alveolar bone absorption in the diabetes group.Conclusion:Marked alveolar bone injury isobserved in rats with STZ-induced diabetes

and micro-CT technique displays the microstructure changes of peri-odontal bone tissue.

关键词

Micro-CTSTZ1型糖尿病牙槽骨

Keywords

Micro-CTStreptozotocinType 1 diabetesAlveolar bone

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