Objective:To investigate the clinical effect of bundle intervention combined with polyethylene film application in critically ill patients with keratopathy as well as the pathogenic factors. Methods:A total of 200 patients with keratopathy treated in the intensive care unit of our hospital were divided into control group（n = 100） and experimental group（n = 100） using a random number table. The patients in the experimental group received bundle intervention combined with polyethylene film application

while the control group was given conventional nursing combined with polyethylene film application. After 2 weeks of intervention

the two groups were compared in terms of sample loss

the severity of keratopathy

and corneal epithelial cell shedding

and the incidence of complications and degree of satisfaction during the nursing period were recorded. Results:After nursing

there was no significant difference in sample loss between the two groups（P > 0.05）

and the experimental group had milder keratopathy than the control group（P < 0.05）. After 2 weeks of intervention

the experimental group had a significantly higher negative rate of both eyes（P < 0.05）

significantly lower incidence rates of conjunctival hyperemia

conjunctival exposure

and corneal exposure（P < 0.05）

and a significantly higher degree of satisfaction（91.00 % vs 70.00 %

P < 0.05）

as compared with the control group. Conclusion:Bundle intervention combined with polyethylene film application helps to alleviate the symptoms of keratopathy and reduce the incidence of complications

with great clinical significance.