Objective:To compare the clinical effect and safety of arteriovenous functional end-to-side anasto-mosis and traditional cephalic vein-radial artery anastomosis on the hemodialysis for uremia. Methods:Sixty-twopatients with uremia who underwent hemodialysis in our hospital from January 2016 to December 2018 were en-rolled and divided into control group（n = 31） and experimental group（n = 31） by single blind random sampling to un-dergo traditional cephalic vein-radial artery anastomosis and arteriovenous functional end-to-side anastomosis

re-spectively. The two groups were compared in terms of anastomotic blood flow

anastomotic diameter

anastomosistime

success rate of anastomosis

1-year patency rate

incidence of complications

and SF-36 score. Results:Com-pared with the control group

the experimental group had significantly higher anastomotic blood flow（P < 0.05）

asignificantly larger anastomotic diameter（P < 0.05）

a significantly shorter anastomosis time（P < 0.05）

a significant-ly higher success rate of anastomosis（96.77% vs 74.19%

P < 0.05）

a significantly higher 1-year patency rate（87.10% vs 56.06 %

P < 0.05）

a significantly lower incidence of complications（6.45% vs 32.26%

P < 0.05）

and asignificantly higher SF-36 score at 1 year after surgery（P < 0.05）. Conclusion:For patients with uremia on hemodi-alysis

arteriovenous functional end-to-side anastomosis can significantly increase anastomotic blood flow and thesuccess rate and patency rate of anastomosis

reduce the incidence of complications

and improve the quality of life

so it holds promise for clinical application.