Cell migration caused by increased intracellular Ca<sup>2+</sup> induced by ATP via P2 receptor and related signaling pathways

CUI Yiqin; YANG Yan

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Cell migration caused by increased intracellular Ca²⁺ induced by ATP via P2 receptor and related signaling pathways

更新时间：2023-04-14

- Cell migration caused by increased intracellular Ca²⁺ induced by ATP via P2 receptor and related signaling pathways
- Journal of Southwest Medical University Vol. 43, Issue 6, Pages: 628-633(2020)
- 作者机构：
  
  西南医科大学心血管医学研究所·医学电生理学教育部重点实验室医学电生理四川省重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R329.2
- Published：2020，
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[1]崔艺琴,杨艳.P2受体介导的ATP诱导胞内Ca~(2+)增加引起的细胞迁移及相关信号通路[J].西南医科大学学报,2020,43(06):628-633.

CUI Yiqin, YANG Yan. Cell migration caused by increased intracellular Ca²⁺ induced by ATP via P2 receptor and related signaling pathways. [J]. Journal of Southwest Medical University 43(6):628-633(2020)
[1]崔艺琴,杨艳.P2受体介导的ATP诱导胞内Ca~(2+)增加引起的细胞迁移及相关信号通路[J].西南医科大学学报,2020,43(06):628-633. DOI：

CUI Yiqin, YANG Yan. Cell migration caused by increased intracellular Ca²⁺ induced by ATP via P2 receptor and related signaling pathways. [J]. Journal of Southwest Medical University 43(6):628-633(2020) DOI：

摘要

细胞迁移在伤口愈合、癌细胞侵袭等生理病理过程中发挥主要作用。细胞迁移是指细胞在接受迁移信号或者感受到某些物质的梯度后产生的移动。越来越多的研究表明

胞外ATP通过激活细胞膜上的P2受体促使细胞内Ca

浓度增加

构成了ATP-Ca

信号机制

影响细胞功能。胞内Ca

是机体包括细胞迁移等多种生理过程的主要第二信使

可通过调控Ca

依赖性相关信号通路产生细胞迁移作用。本文综述近年来关于参与ATP诱导细胞内Ca

浓度增加作用中P2受体的研究

讨论ATP引起胞内Ca

增加导致的细胞迁移以及参与调控的相关信号通路

为相关疾病的治疗提供新的靶点和方法。

Abstract

Cell migration plays an important role in the physiological and pathological processes including wound healing and cancer cell invasion.Cell migration refers to the movement of cells after they receive migration signals or feel the gradient of certain substances.More and more studies have shown that extracellular adenosine triphosphate（ATP）promotes the increase in intracellular Ca

concentration by activating P2 receptors on cell membrane

which constitutes the ATP-Ca

signaling mechanism and affects cell function.Intracellular Ca

is the main second messenger of many physiological processes in the body

including cell migration

and it can induce cell migration by regulating Ca

-dependent signaling pathways.This article reviews the recent studies on P2 receptors involved in ATP induction of increased intracellular Ca

concentration and discusses cell migration caused by increased intracellular Ca

and related signaling pathways involved in regulation

so as to provide new targets and methods for the treatment of related diseases.

关键词

P2受体ATP胞内Ca2+细胞迁移

Keywords

P2 receptorAdenosine triphosphateIntracellular Ca2+Cell migration

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Cell migration caused by increased intracellular Ca2+ induced by ATP via P2 receptor and related signaling pathways

DOI：

摘要

Abstract

关键词

Keywords

references

Cell migration caused by increased intracellular Ca²⁺ induced by ATP via P2 receptor and related signaling pathways