Expression of MARCH2 and NF-κB in invasive breast cancer and its clinical significance

LU Zijian; WANG Yong; ZOU Longquan; CHEN Qianxing; SHAO Shuai

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Expression of MARCH2 and NF-κB in invasive breast cancer and its clinical significance

更新时间：2023-04-14

- Expression of MARCH2 and NF-κB in invasive breast cancer and its clinical significance
- Journal of Southwest Medical University Vol. 43, Issue 6, Pages: 581-585(2020)
- 作者机构：
  
  自贡市第四人民医院病理科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2020，
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[1]卢子剑,王勇,邹龙权,陈芊杏,邵率.MARCH2和NF-κB在浸润性乳腺癌中的表达及其意义[J].西南医科大学学报,2020,43(06):581-585.

LU Zijian, WANG Yong, ZOU Longquan, et al. Expression of MARCH2 and NF-κB in invasive breast cancer and its clinical significance. [J]. Journal of Southwest Medical University 43(6):581-585(2020)
[1]卢子剑,王勇,邹龙权,陈芊杏,邵率.MARCH2和NF-κB在浸润性乳腺癌中的表达及其意义[J].西南医科大学学报,2020,43(06):581-585. DOI：

LU Zijian, WANG Yong, ZOU Longquan, et al. Expression of MARCH2 and NF-κB in invasive breast cancer and its clinical significance. [J]. Journal of Southwest Medical University 43(6):581-585(2020) DOI：

摘要

目的:检测浸润性乳腺癌组织及癌旁正常乳腺组织中膜相关环指蛋白2（membrane-associated ring CH2

MARCH2）和核转录因子κB（nuclear transcription factor-κB

NF-κB）的表达

探讨MARCH2、NF-κB在浸润性乳腺癌中的表达与临床病理参数之间的关系。方法:收集自贡市第四人民医院2018年1月至12月期间接受外科手术治疗的浸润性乳腺癌患者肿瘤组织及距肿瘤边缘﹥3 cm处的正常乳腺石蜡组织各40例。采用免疫组织化学Envision法对组织标本中的MARCH2蛋白、NF-κB蛋白进行标记。结果:在40例浸润性乳腺癌患者肿瘤组织中

MARCH2在癌组织中阳性表达36例（阳性表达率90.0%）

癌旁组织阳性表达7例（χ

=42.288

P﹤0.05）。NF-κB在癌组织中阳性表达30例（阳性表达率75.0%）

癌旁正常组织阳性表达5例（χ

=31.746

P﹤0.05）。关联性分析结果表明

两种蛋白的表达呈中度正相关（r﹦0.577

=13.333

P﹤0.01）。结论:MARCH2和NF-κB在浸润性乳腺癌组织中呈高表达

乳腺癌的发生发展可能与MARCH2的高表达有关

NF-κB可能是乳腺癌发生发展的重要信号通路。

Abstract

Objective:To determine the expression of membrane-associated RING-CH 2（MARCH2）and nuclear factor-kappa B（NF-κB）in invasive breast cancer tissues and adjacent normal tissues

and to explore the relationship between the expression of MARCH2 and NF-κB and the clinicopathological parameters of invasive breast cancer.Methods:We collected cancer tissues and normal breast tissues（more than 3 cm from the edge of the cancer）from 40 patients with invasive breast cancer who underwent surgical treatment from January to December 2018 in Zigong Fourth People’s Hospital.The immunohistochemical method EnVision was used to label MARCH2 and NF-κB in the tissues.Results:MARCH2 was positive in 36（90.0%）of the 40 cancer tissues

and in 7 adjacent normal tissues（χ

= 42.288

0.05）.NF-κB was positive in 30（75.0%）cancer tissues

and in 5 adjacent normal tissues（χ

= 31.746

0.05）.There was a moderate positive correlation between the expression of the two proteins（r = 0.577

= 13.333

0.01）.Conclusion:MARCH2 and NF-κB are highly expressed in invasive breast cancer tissues.The development and progression of breast cancer may be related to the high expression of MARCH2

and NF-κB may be an important signaling pathway.

关键词

浸润性乳腺癌MARCH2NF-κB炎症

Keywords

Invasive breast cancerMARCH2NF-κBInflammation

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