Advances in the study of immune cell changes after ischemic stroke

JIAN Xiaoli; YIN Siyuan; ZHANG Dechou

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Advances in the study of immune cell changes after ischemic stroke

更新时间：2023-04-14

- Advances in the study of immune cell changes after ischemic stroke
- Journal of Southwest Medical University Vol. 43, Issue 5, Pages: 524-527(2020)
- 作者机构：
  
  1. 西南医科大学附属中医医院心脑病科
  2. 西南医科大学教务处
- 作者简介：
- 基金信息：
- DOI：
  CLC： R743.3
- Published：2020，
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[1]简晓莉,尹思源,张德绸.缺血性脑卒中后免疫细胞变化的研究进展[J].西南医科大学学报,2020,43(05):524-527.

JIAN Xiaoli, YIN Siyuan, ZHANG Dechou. Advances in the study of immune cell changes after ischemic stroke. [J]. Journal of Southwest Medical University 43(5):524-527(2020)
[1]简晓莉,尹思源,张德绸.缺血性脑卒中后免疫细胞变化的研究进展[J].西南医科大学学报,2020,43(05):524-527. DOI：

JIAN Xiaoli, YIN Siyuan, ZHANG Dechou. Advances in the study of immune cell changes after ischemic stroke. [J]. Journal of Southwest Medical University 43(5):524-527(2020) DOI：

摘要

急性缺血性脑卒中后

继发性神经炎症既可促进脑组织的损伤导致细胞死亡

同时也有促进患者康复的作用。来自免疫介质的促炎信号迅速激活驻留神经小胶质细胞

并影响多种炎症细胞（中性粒细胞、单核巨噬细胞、不同亚型T细胞和其他炎症细胞）浸润到缺血区

引起免疫炎症过度反应

加重脑组织损伤;亦有相关研究显示

部分免疫细胞对脑组织有保护作用。本文就缺血性脑卒中后免疫细胞的变化进行深入认识

并进一步探讨免疫相关的靶向治疗

其对患者的预后有重要意义。

Abstract

After acute ischemic stroke

secondary neuroinflammation can not only promote the damage of brain tissues and lead to cell death

but also promote the rehabilitation of patients. Proinflammatory signals from immune mediators rapidly activate the resident microglia and affect a variety of inflammatory cells（neutrophils

mononuclear macrophages

different subtypes of T cells

and other inflammatory cells） to infiltrate into the ischemic area

causing an overreaction of immune inflammation and aggravating the brain tissue damage. However

there are also some related studies which demonstrate that some immune cells have a protective effect on brain tissues. This article reviews the changes in imune cells after ischemic stroke

and further discusses the immune-related targeted therapy

which is of great significance to the prognosis of patients.

关键词

缺血性脑卒中免疫细胞靶向治疗

Keywords

Ischemic strokeImmune cellsTargeted therapy

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