Current research on the role and mechanism of action of calcium signal in regulating stem cell migration

WEI Xiaoyu; YANG Yan

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Current research on the role and mechanism of action of calcium signal in regulating stem cell migration

更新时间：2023-04-14

- Current research on the role and mechanism of action of calcium signal in regulating stem cell migration
- Journal of Southwest Medical University Vol. 43, Issue 5, Pages: 519-523(2020)
- 作者机构：
  
  西南医科大学心血管医学研究所医学电生理学教育部和四川省重点实验室四川省心血管疾病防治协同创新中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R329.2
- Published：2020，
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[1]卫潇玉,杨艳.钙信号在调节干细胞迁移中的作用及机制研究现状[J].西南医科大学学报,2020,43(05):519-523.

WEI Xiaoyu, YANG Yan. Current research on the role and mechanism of action of calcium signal in regulating stem cell migration. [J]. Journal of Southwest Medical University 43(5):519-523(2020)
[1]卫潇玉,杨艳.钙信号在调节干细胞迁移中的作用及机制研究现状[J].西南医科大学学报,2020,43(05):519-523. DOI：

WEI Xiaoyu, YANG Yan. Current research on the role and mechanism of action of calcium signal in regulating stem cell migration. [J]. Journal of Southwest Medical University 43(5):519-523(2020) DOI：

摘要

钙离子(calcium ion

)作为第二信使

在调节包括干细胞迁移在内的许多生理过程中发挥重要作用。各种细胞外因子触发细胞内Ca

水平升高

激活下游Ca

依赖性信号分子调节细胞迁移。近年来荧光细胞钙成像技术使我们得以了解干细胞如何在细胞前缘发出Ca

脉冲

从细胞背面到正面保持胞内Ca

的浓度梯度

及如何恢复Ca

耗竭等细胞爬行机制。另外

关于细胞外因子触发研究中

有关胞外腺嘌呤核苷三磷酸（adenosine triphosphate

ATP）的研究认为

ATP可以激活细胞膜上的G蛋白偶联受体P2受体

可因与Gα亚基和下游信号通路耦合

从而激活Ga

q-PLC-IP3R信号通路

（PIP2）转换成（IP3）和（DAG）

IP3受体活化进而从内质网中释放Ca

激活PKC-ERK1/2信号通路等。对局部钙信号、Ca

转运蛋白的相互作用等干细胞迁移调控机制的认识

可能为治疗有关疾病提供新的方向。

Abstract

As a second messenger

calcium ion(Ca

) plays an important role in regulating many physiological processes including stem cell migration. Various extracellular factors trigger an increase in intracellular Ca

levels and activate the downstream Ca

-dependent signaling molecules to regulate cell migration. In recent years

calcium imaging technology has enabled us to understand the cell crawling mechanisms such as how stem cells send out Ca

pulses at the leading edge of the cell

maintain the intracellular Ca

concentration gradient from the back to the front of the cell

and restore Ca

depletion. In addition

in terms of the studies of extracellular factor triggering

studies on extracellular adenosine triphosphate（ATP） reveal that ATP can activate the G protein-coupled receptor P2 receptor on the cell membrane

which can be coupled to the Gα subunit（Gαq） and the downstream signaling pathways to activate the Gαq-PLC-IP3 R signaling pathway so that PIP2 is converted to IP3 and DAG

IP3 receptor is activated

and then Ca

is released from the endoplasmic reticulum to activate the PKC-ERK1/2 signaling pathway. To understand the mechanism of stem cell migration and regulation such as local calcium signal and the interactions between Ca

transport proteins may provide a new direction for the treatment of related diseases.

关键词

Ca2+信号转导Gaq-PLC-IP3R信号通路PKC-ERK1/2信号通路干细胞细胞迁移

Keywords

Ca2+ signal transductionGαq-PLC-IP3R signaling pathwayPKC-ERK1/2 signaling pathwayStem cellCell migration

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