Correlation analysis of high sensitive C-reactive protein and cardiac function in patients with chronic heart failure complicated by atrial fibrillation

LIUHUO Wusha; TANG Chao; ZHAO Lizhi

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Correlation analysis of high sensitive C-reactive protein and cardiac function in patients with chronic heart failure complicated by atrial fibrillation

更新时间：2023-04-14

- Correlation analysis of high sensitive C-reactive protein and cardiac function in patients with chronic heart failure complicated by atrial fibrillation
- Journal of Southwest Medical University Vol. 43, Issue 5, Pages: 487-491(2020)
- 作者机构：
  
  西南医科大学附属中医院心血管内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.75;R541.6
- Published：2020，
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[1]刘火五沙,唐超,赵立志.超敏C反应蛋白与慢性心力衰竭合并房颤患者心功能相关性分析[J].西南医科大学学报,2020,43(05):487-491.

LIUHUO Wusha, TANG Chao, ZHAO Lizhi. Correlation analysis of high sensitive C-reactive protein and cardiac function in patients with chronic heart failure complicated by atrial fibrillation. [J]. Journal of Southwest Medical University 43(5):487-491(2020)
[1]刘火五沙,唐超,赵立志.超敏C反应蛋白与慢性心力衰竭合并房颤患者心功能相关性分析[J].西南医科大学学报,2020,43(05):487-491. DOI：

LIUHUO Wusha, TANG Chao, ZHAO Lizhi. Correlation analysis of high sensitive C-reactive protein and cardiac function in patients with chronic heart failure complicated by atrial fibrillation. [J]. Journal of Southwest Medical University 43(5):487-491(2020) DOI：

摘要

目的:探讨超敏C反应蛋白（high sensitive C-reactive protein

hs-CRP）水平与慢性心力衰竭（chronic heart failure

CHF）合并心房颤动（atrial fibrillation

AF）患者心功能相关性。方法:收集2014年3月至2016年6月入住我院心内科的心衰患者215例。根据ECG或24 h动态心电图以及hs-CRP水平将患者分为慢性心力衰竭伴窦性心律组、慢性心力衰竭伴心房颤动组、低hs-CRP组（≤9.9 mg/L）、高hs-CRP组（> 9.9 mg/L）。分析hs-CRP水平与慢性心衰合并房颤心功能的相关性。结果:与低hs-CRP组比较

高hs-CRP组NT-proBNP水平（P <0.01）、纽约心脏病协会心功能分级（new york heart association

NYHA）（P <0.05）更高

左室射血分数（lefs ventricular eiection fraction

LVEF）更低（P <0.01）;与CHF伴窦律组比较

CHF伴房颤组NT-proBNP水平（P <0.01）、hs-CRP水平（P <0.01）以及NYHA分级（P <0.01）更高

LVEF则更低（P <0.05）;hs-CRP与LVEF水平呈负相关（r=0.400

P <0.05）;hs-CRP与NT-proBNP呈正相关（r=0.338

P <0.05）。结论:在心衰伴房颤人群中

外周血中的hs-CRP水平更高

炎症反应重

心功能更差

疾病更加严重。

Abstract

Objective: To investigate the correlation between high sensitive C-reactive protein（hs-CRP） level and cardiac function in patients with chronic heart failure（CHF） complicated by atrial fibrillation. Methods: A total of 215 patients with heart failure admitted to our hospital from March 2014 to June 2016 were enrolled as subjects.According to electrocardiography（ECG）/24-hour ambulatory ECG and the hs-CRP level

patients were divided into CHF with sinus rhythm group

CHF with atrial fibrillation group

low hs-CRP group（≤ 9.9 mg/L）

and high hs-CRP group（> 9.9 mg/L）. A correlation analysis was performed on the hs-CRP level and cardiac function in CHF complicated by atrial fibrillation. Results: Compared with the low hs-CRP group

the high hs-CRP group had a significantly higher N-terminal pro-brain natriuretic peptide（NT-proBNP） level（P < 0.01）

a significantly higher New York Heart Association（NYHA） grade（P < 0.05）

and a significantly lower left ventricular ejection fraction（LVEF）（P <0.01）. Compared with the CHF with sinus rhythm group

the CHF with atrial fibrillation group had significantly higher NT-proBNP level（P < 0.01）

hs-CRP level（P < 0.01）

and NYHA grade（P < 0.01） but a significantly lower LVEF（P < 0.05）. The hs-CRP level was negatively correlated with LVEF（r =-0.400

P < 0.05） but positively correlated with the NT-proBNP level（r = 0.338

P < 0.05）. Conclusion: Patients with heart failure complicated by atrial fibrillation have a high hs-CRP level and a strong inflammatory response

which result in poor cardiac function and severe disease.

关键词

超敏C反应蛋白心房颤动心力衰竭心功能相关性

Keywords

High sensitive C-reactive proteinohs-CRPAtrial fibrillationHeart failureCardiac functionCorrelation

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西南医科大学附属医院：

Key Laboratory of Medi⁃ cal Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province，Collaborative Inno⁃ vation Center for Prevention and Treatment of Cardiovascular Disease，Institute of Cardiovascular Research，Southwest Medical University

Department of Cardiology，Affiliated Hospital of Southwest Medical University

⁰