Relationship of E-cadherin,β-catenin,and matrix metalloproteinase-7 with degree of oral squamous cell carcinoma differentiation

LI Xiu; NIE Minhai; LIU Xuqian; TAN Hong

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Relationship of E-cadherin,β-catenin,and matrix metalloproteinase-7 with degree of oral squamous cell carcinoma differentiation

更新时间：2023-04-14

- Relationship of E-cadherin,β-catenin,and matrix metalloproteinase-7 with degree of oral squamous cell carcinoma differentiation
- Journal of Southwest Medical University Vol. 43, Issue 2, Pages: 124-129(2020)
- 作者机构：
  
  1. 西南医科大学附属口腔医院牙周黏膜科
  2. 西南医科大学口颌面修复重建与再生实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.8
- Published：2020，
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[1]李秀,聂敏海,刘旭倩,谭红.E-钙粘蛋白、β-连环素和基质金属蛋白酶-7与口腔鳞状细胞癌分化程度的关系[J].西南医科大学学报,2020,43(02):124-129.

LI Xiu, NIE Minhai, LIU Xuqian, et al. Relationship of E-cadherin,β-catenin,and matrix metalloproteinase-7 with degree of oral squamous cell carcinoma differentiation. [J]. Journal of Southwest Medical University 43(2):124-129(2020)
[1]李秀,聂敏海,刘旭倩,谭红.E-钙粘蛋白、β-连环素和基质金属蛋白酶-7与口腔鳞状细胞癌分化程度的关系[J].西南医科大学学报,2020,43(02):124-129. DOI：

LI Xiu, NIE Minhai, LIU Xuqian, et al. Relationship of E-cadherin,β-catenin,and matrix metalloproteinase-7 with degree of oral squamous cell carcinoma differentiation. [J]. Journal of Southwest Medical University 43(2):124-129(2020) DOI：

摘要

目的:探讨E-钙粘蛋白（E-cadherin）、β-连环素（β-catenin）和基质金属蛋白酶-7（MMP-7）在口腔鳞状细胞癌（OSCC）中的表达及意义。方法:采用免疫组化SP法检测OSCC中E-cadherin、β-catenin和MMP-7蛋白的表达情况

并探讨相关性。结果:与正常口腔黏膜组织相比

OSCC中E-cadherin及β-catenin的阳性表达率明显降低

MMP-7的阳性表达率明显增高

差异均具有统计学意义（P <0.05）;随着OSCC分化程度的降低

E-cadherin及β-catenin的阳性表达水平逐渐下调

MMP-7的阳性表达水平逐步上调

差异均具有统计学意义（P <0.05）。在OSCC中

E-cadherin和β-catenin阳性表达呈正相关关系（r=0.750

P <0.001）

两者与MMP-7阳性表达均成负相关关系（r=-0.659

P <0.001;r=-0.604

P <0.001）。结论:在OSCC中

E-cadherin、β-catenin及MMP-7的表达与OSCC分化程度密切相关。

Abstract

Objective: To investigate the expression and significance of E-cadherin

β-catenin

and matrix metalloproteinase-7（MMP-7） in oral squamous cell carcinoma（OSCC）. Methods: The method of immunohistochemistry（SP） was used to determine the expression of E-cadherin

β-catenin

and MMP-7 in OSCC

and the correlations between them were explored. Results: Compared with the normal oral mucosal tissues

OSCC had significantly lower positive expression rates of E-cadherin and β-catenin and a significantly higher positive expression rate of MMP-7（P < 0.05）. With the decrease in the degree of OSCC differentiation

the positive expression rates of E-cadherin and β-catenin were gradually down-regulated

and the positive expression rate of MMP-7 was gradually up-regulated（P < 0.05）. In OSCC

there was a positive correlation between the positive expression rates of E-cadherin and β-catenin（r = 0.750

P <0.001）

and both of them were negatively correlated with the positive expression rate of MMP-7（r =-0.659

P < 0.001; r =-0.604

P < 0.001）. Conclusion: In OSCC

the expression of E-cadherin

β-catenin

and MMP-7 is closely related to the degree of OSCC differentiation.

关键词

OSCCE-cadherinβ-cateninMMP-7

Keywords

Oral squamous cell carcinomaE-cadherinβ-CateninMatrix metalloproteinase-7

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Related Institution

Department of Periodontics and Oral Medicine ,the Affiliated Stomatology Hospital of Southwest Medical University

Department of Orthodontics,Mianyang Stomatological Hospital

Hebei Provincical Center for Disease Control and Prevention

Department of Stomatology of the Shehong People’s Hospital

the Affiliated Stomatological Hospital of Southwest Medical University

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