Research advances in the role of regulation of the ORAI/STIM channel by oxidative stress in cardiovascular diseases

HE Dongmei; LI Pengyun

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Research advances in the role of regulation of the ORAI/STIM channel by oxidative stress in cardiovascular diseases

更新时间：2023-04-14

- Research advances in the role of regulation of the ORAI/STIM channel by oxidative stress in cardiovascular diseases
- Journal of Southwest Medical University Vol. 43, Issue 1, Pages: 66-71(2020)
- 作者机构：
  
  西南医科大学心血管医学研究所医学电生理学教育部和四川省重点实验室四川省心血管疾病防治协同创新中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R54
- Published：2020，
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[1]何东梅,李鹏云.氧化应激调控ORAI/STIM通道在心血管疾病中的作用及进展[J].西南医科大学学报,2020,43(01):66-71.

HE Dongmei, LI Pengyun. Research advances in the role of regulation of the ORAI/STIM channel by oxidative stress in cardiovascular diseases. [J]. Journal of Southwest Medical University 43(1):66-71(2020)
[1]何东梅,李鹏云.氧化应激调控ORAI/STIM通道在心血管疾病中的作用及进展[J].西南医科大学学报,2020,43(01):66-71. DOI：

HE Dongmei, LI Pengyun. Research advances in the role of regulation of the ORAI/STIM channel by oxidative stress in cardiovascular diseases. [J]. Journal of Southwest Medical University 43(1):66-71(2020) DOI：

摘要

氧化应激参与调控细胞增殖

分化和死亡等一系列生命过程

被认为是影响多种疾病的重要因素。其中Ca2+信号在此调控过程中发挥重要的作用

但是氧化应激影响钙信号的机制目前尚不明确。ORAI/STIM通道是细胞膜上普遍存在的钙库操纵的Ca2+通道（store-operated Ca2+channel

SOCC）的主要分子构成单位

在细胞内钙稳态调控过程中发挥重要作用。近年来研究发现STIM1也是一个重要的氧化应激感受器

参与生理或病理条件下氧化应激对细胞内钙信号的调控。大量研究表明

氧化应激在心脑血管疾病的发病机制中不可或缺

但目前氧化应激与ORAI/STIM的相关性及其调控机制并不明确

尚存在一些争议。因此进一步阐明ORAI/STIM介导的钙信号与氧化应激之间的相关性具有重要的科学意义和医学价值。本文旨在简述氧化应激调控ORAI/STIM介导的钙库操纵的Ca2+内流（store-operated Ca2+entry

SOCE）的机制及其在心血管疾病发生发展过程中的相关研究进展。

Abstract

Oxidative stress is involved in regulating a series of life processes including cell proliferation

differentiation

and death

and it is considered to be an important influencing factor for many diseases. Ca2 +signals are known to play an important role in the regulation processes

yet it is not clear how oxidative stress affects Ca2+signals. The ORAI/STIM channel

the main molecular component of the store-operated calcium channel widely distributed in the cell membrane

contributes to regulation of intracellular calcium homeostasis. Recent studies have demonstrated that STIM1 is an important oxidative stress receptor

participating in regulation of intracellular calcium signals by oxidative stress under physiological or pathophysiological conditions. Numerous studies have shown that oxidative stress is essential in the pathogenesis of cardiovascular and cerebrovascular diseases. However

the association of oxidative stress with ORAI/STIM and related regulation mechanisms remain controversial. Therefore

it is of great significance and medical value to further clarify the relationship between ORAI/STIM-mediated calcium signals and oxidative stress. This review summarizes the mechanisms by which oxidative stress regulates ORAI/STIM-mediated storeoperated calcium entry and relevant research progress in the development and progression of cardiovascular diseases.

关键词

氧化应激ORAISTIM钙信号

Keywords

Oxidative stressORAISTIMCalcium signal

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