Objective: To investigate the effect of oral liquid of Rosa roxburghii Tratt and Crataegus pinnatifida on the lipid metabolism and lipoprotein lipase（LPL） gene expression in patients with hyperlipidemic acute pancreatitis（HAP）. Methods: A total of 60 patients with HAP who attended Department of Hepatobiliary and Pancreatic Surgery in our hospital from December 2017 to December 2018 were enrolled and divided into control group and experimental group

with 30 patients in each group. The patients in the control group received routine treatments such as fasting

gastrointestinal decompression

inhibition of pancreatic enzyme secretion

anti-acid therapy

and anti-infective therapy

and those in the experimental group were given refined oral liquid of Rosa roxburghii Tratt and Crataegus pinnatifida in addition to the treatment in the control group. After 2 weeks of treatment

serum levels of total cholesterol（TC）

triglyceride（TG）

high-density lipoprotein cholesterol（HDL-C）

and low-density lipoprotein cholesterol（LDL-C） were measured to evaluate the antihyperlipidemic effect of Rosa roxburghii Tratt and Crataegus pinnatifida in patients with HAP. Quantitative real-time PCR was used to measure the mRNA expression of LPL in liver tissue

and Western blot was used to measure the protein expression of LPL

so as to explore the antihyperlipidemic mechanism of the oral liquid of Rosa roxburghii Tratt and Crataegus pinnatifida. Results:Both groups had significant changes in serum TC

TG

HDL-C

and LDL-C after treatment（P < 0.05）. Compared with the control group

the experimental group had significant increases in the mRNA and protein expression of LPL in liver tissue（t = 3.791

P = 0.006）. Conclusion:Oral liquid of Rosa roxburghii Tratt and Crataegus pinnatifida can effectively regulate the expression of LPL gene in patients with HAP and thus delay the progression of pancreatitis.