Expression and clinical significance of long non-coding RNA ABHD11-AS1 in cervical cancer

HUANG Jing; LIN Yierong; LI Juan

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Expression and clinical significance of long non-coding RNA ABHD11-AS1 in cervical cancer

更新时间：2023-04-14

- Expression and clinical significance of long non-coding RNA ABHD11-AS1 in cervical cancer
- Journal of Southwest Medical University Vol. 43, Issue 1, Pages: 24-27(2020)
- 作者机构：
  
  1. 漳州卫生职业学院临床医学系妇外教研室
  2. 厦门大学附属东南医院妇产科
  3. 漳州市芗城区妇幼保健院妇产科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.33
- Published：2020，
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[1]黄晶,林也容,李娟.lncRNA ABHD11-AS1在宫颈癌中的表达及其临床意义[J].西南医科大学学报,2020,43(01):24-27+31.

HUANG Jing, LIN Yierong, LI Juan. Expression and clinical significance of long non-coding RNA ABHD11-AS1 in cervical cancer. [J]. Journal of Southwest Medical University 43(1):24-27(2020)
[1]黄晶,林也容,李娟.lncRNA ABHD11-AS1在宫颈癌中的表达及其临床意义[J].西南医科大学学报,2020,43(01):24-27+31. DOI：

HUANG Jing, LIN Yierong, LI Juan. Expression and clinical significance of long non-coding RNA ABHD11-AS1 in cervical cancer. [J]. Journal of Southwest Medical University 43(1):24-27(2020) DOI：

摘要

目的:探讨长链非编码lncRNA ABHD11-AS1在宫颈癌中的表达及其与患者诊断及预后的关系。方法:采用实时荧光定量PCR检测方法

检测50例宫颈癌患者的血液标本及对照组中lncRNA ABHD11-AS1的表达水平

同时分析lncRNA ABHD11-AS1的相对表达量与宫颈癌患者诊断、临床病理特征及预后的关系。结果:lncRNA ABHD11-AS1在宫颈癌患者血液标本及对照组中的相对表达水平分别为（1.80±0.11）和（1.17±0.08）

差异有统计学意义（P <0.05）。lncRNA ABHD11-AS1的表达水平与宫颈癌患者的淋巴结转移

淋巴管血管侵袭、肿瘤大小及FIGO分期有关（P <0.05）

而与患者的年龄、绝经情况等均无关

同时ROC显示lncRNA ABHD11-AS1作为宫颈癌标志物具有一定的诊断意义。与lncRNA ABHD11-AS1低表达组比较

lncRNA ABHD11-AS1高表达组患者的中位OS明显缩短（P <0.05）。结论:lncRNA ABHD11-AS1在宫颈癌中的表达水平升高

lncRNA ABHD11-AS1可以作为判断宫颈Ca预后的分子标志物。

Abstract

Objective:To investigate the expression of the long non-coding RNA（lncRNA） ABHD11-AS1 in cervical cancer and its association with diagnosis and prognosis. Methods:Quantitative real-time PCR was used to measure the expression level of lncRNA ABHD11-AS1 in blood samples of 50 patients with cervical cancer and the subjects in the control group

and the association of the relative expression level of lncRNA ABHD11-AS1 with the diagnosis

clinicopathological features

and prognosis of cervical cancer patients was analyzed. Results:There was a significant difference in the relative expression level of lncRNA ABHD11-AS1 in blood samples between the patients with cervical cancer and the control group（1.80 ± 0.11 vs 1.17 ± 0.08

P < 0.05）. The expression level of lncRNA ABHD11-AS1 was associated with lymph node metastasis

lymphatic vessel invasion

tumor size

and FIGO stage in patients with cervical cancer（P < 0.05）

while it was not associated with patients’ age and menopause status. The receiver operating characteristic curve analysis showed that lncRNA ABHD11-AS1 had certain diagnostic significance as a marker for cervical cancer. Compared with the low lncRNA ABHD11-AS1 expression group

the high lncRNA ABHD11-AS1 expression group had a significantly shorter median OS（P < 0.05）. Conclusion:The expression of lncRNA ABHD11-AS1 is upregulated in cervical cancer

and lncRNA ABHD11-AS1 can be used as a potential molecular marker for diagnosis and prognosis.

关键词

IncRNA ABHD11-ASI宫颈癌表达临床意义

Keywords

Cervical cancerExpressionClinical significance

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