Objective: To investigate the effects of blood-activating and stasis-resolving drugs

wind drugs

and their combination on the blood-brain barrier permeability of rats with cerebral ischemia. Methods: Seventy-five healthy male Sprague-Dawley rats were randomly divided into sham-operation group

model group

blood-activating group

wind drug group

and combination group. A rat model of middle cerebral artery occlusion was established by the suture method. Gavage began 24 hours after the model was established and continued for 7 days. Then neurological function impairment score was evaluated. Cerebral infarct volume and the water content and Evans blue content of brain tissue were compared between different groups. Results: Compared with the model group

all the treatment groups

to varying degrees

significantly improved the neurological function of the rats and significantly reduced cerebral infarct volume and the water content and Evans blue content of brain tissue（P < 0.01）. The combination group had significantly greater improvements in those indicators compared with the blood-activating group and wind drug group（P < 0.05）. Conclusion: Wind drugs can enhance the efficacy of blood-activating and stasis-resolving drugs

and their combination can

to a larger extent

decrease blood-brain barrier permeability and alleviate brain edema

protecting brain tissue from further injury.