Objective To examine the clinical efficacy of midnight-noon ebb-flow acupoint application in the treatment of coronary heart disease. Methods One hundred patients with coronary heart disease treated in the cardiology department of a hospital in Shenyang from December 2018 to June 2019 were selected for the study. The random number table method was used to randomly divide the patients into the control group and the treatment group

with 50 cases in each group. Patients in the control group were treated with conventional Western medicine.Patients in the treatment group were treated with midnight-noon ebb-flow acupoint application on the basis of Western medical treatment. The scores for primary TCM symptoms were compared before and after treatment;the treatment effects of the two groups were compared on day 20; the levels of interleukin-4（IL-4）

interleukin-10（IL-10）

interleukin-2（IL-2） and gamma interferon（IFN-γ） in the two groups were compared before and after treatment. Results The total effective rate of treatment for patients in the treatment group was90.00%

which was higher than the 66.00% in the control group

and the difference was statistically significant（P <0.05）. After treatment

the scores for chest pain

chest tightness

coldness in the extremities

heaviness in the extremities

and dizziness in the primary TCM symptoms in the treatment group were（1.00±0.31）

（0.95±0.24）

（1.01±0.27）

（0.82±0.25） and（1.02±0.27） points

respectively

which were lower than the control group’s（3.05±0.99）

（3.02±1.00）

（3.40±0.96）

（3.03±0.95）

and（3.11±0.95） points

with statistically significant differences（P <0.05）. After treatment

the levels of IL-4 and IL-10 were（40.77±5.87） ng/mL and（32.22±4.10） ng/mL

respectively

in patients in the treatment group

which were higher than the（34.11±6.11） ng/mL and（23.14±6.49） ng/mL in the control group

while the levels of IL-2 and IFN-γ in patients in the treatment group were（11.99±2.44） ng/mL and（177.73±24.01） ng/mL

respectively

which were lower than the（18.43±6.17） ng/mL and（201.19±22.37） ng/mL in the control group

and the differences were statistically significant（P <0.05）. Conclusion Western medical treatment combined with midnight-noon ebb-flow acupoint application treatment can correct IL-4

IL-10

IL-2

and IFN-γ levels in patients with coronary heart disease

improve symptoms of chest pain

chest tightness

coldness

limb heaviness

and dizziness

and increase the therapeutic efficiency. This treatment method is safe and effective

and it is worth promoting in clinical practice.