Clinical outcomes of respiratory training in combination with budesonide formoterol for stable chronic obstructive pulmonary disease

Li Yuefei; Xu Jinghua; Yang Yong; Shi Hanbing; Li Sheng

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Clinical outcomes of respiratory training in combination with budesonide formoterol for stable chronic obstructive pulmonary disease

更新时间：2021-08-23

- Clinical outcomes of respiratory training in combination with budesonide formoterol for stable chronic obstructive pulmonary disease
- Health Medicine Research and Practice Vol. 17, Issue 5, Pages: 45-49(2020)
- 作者机构：
  
  辽宁中医药大学附属第四医院急诊科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R563.9
- Published：2020，
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[1]李跃飞,徐靖华,杨永,史晗冰,李圣.呼吸训练联合布地奈德福莫特罗治疗慢性阻塞性肺疾病稳定期的临床效果[J].保健医学研究与实践,2020,17(05):45-49.

Li Yuefei, Xu Jinghua, Yang Yong, et al. Clinical outcomes of respiratory training in combination with budesonide formoterol for stable chronic obstructive pulmonary disease. [J]. Health Medicine Research and Practice 17(5):45-49(2020)
[1]李跃飞,徐靖华,杨永,史晗冰,李圣.呼吸训练联合布地奈德福莫特罗治疗慢性阻塞性肺疾病稳定期的临床效果[J].保健医学研究与实践,2020,17(05):45-49. DOI：

Li Yuefei, Xu Jinghua, Yang Yong, et al. Clinical outcomes of respiratory training in combination with budesonide formoterol for stable chronic obstructive pulmonary disease. [J]. Health Medicine Research and Practice 17(5):45-49(2020) DOI：

摘要

目的探讨呼吸训练联合布地奈德福莫特罗治疗慢性阻塞性肺疾病（COPD）稳定期的临床疗效。方法选取2017年1月-2019年12月辽宁省某医院收治的90例COPD稳定期患者为研究对象

采用随机数字表法分成对照组和实验组

每组45例。对照组患者给予布地奈德福莫特罗吸入剂治疗

实验组患者在对照组基础上配合呼吸训练进行治疗

均治疗16周。比较2组患者治疗前后肺功能指标[用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、FEV1/FVC]、血清生化指标[白介素（IL）-17A、C反应蛋白（CRP）、IL-6]

、血气分析指标[动脉血氧分压（Pa O

）、动脉二氧化碳分压（Pa CO

）]、生活质量[圣乔治呼吸问卷（SGRQ）评分]

及临床疗效。结果实验组患者的治疗总有效率为95.56%

高于对照组的80.00%

差异有统计学意义（P

0.05）。治疗前

2组患者FVC、FEV1及FEV1/FVC水平比较

差异无统计学意义（P

0.05）;治疗后

2组患者FVC、FEV

及FEV

/FVC水平均明显高于治疗前

且实验组患者高于对照组

差异均有统计学意义（P

0.05）。治疗前

2组患者Pa CO

及Pa O

水平比较

差异无统计学意义（P

0.05）;治疗后

2组患者Pa CO

水平均低于治疗前

Pa O

水平均高于治疗前

且实验组患者Pa CO

水平低于对照组

Pa O

水平高于对照组

差异均有统计学意义（P

0.05）。治疗前

2组患者血清IL-17A、IL-6、CRP水平比较

差异无统计学意义（P

0.05）;治疗后

2组患者IL-17A、IL-6、CRP水平均低于治疗前

且实验组患者低于对照组

差异均有统计学意义（P

0.05）。治疗前

2组患者SGRQ评分比较

差异无统计学意义（P

0.05）;治疗后

2组患者SGRQ中肺部症状、活动能力、疾病影响维度评分均低于治疗前

且实验组患者低于对照组

差异均有统计学意义（P

0.05）。结论呼吸训练联合布地奈德福莫特罗有助于改善稳定期COPD患者炎症状态和肺功能

提高患者生活质量

临床疗效显著

值得推广。

Abstract

Objective To investigate the clinical efficacy of respiratory training combined with budesonide formoterol in the treatment of chronic obstructive pulmonary disease（COPD） in the stable stage. Methods Ninety patients with stable COPD admitted to a hospital in Liaoning Province from January 2017 to December 2019 were selected and divided into a control group and an experimental group with 45 patients in each group using a randomized numerical table. Patients in the control group were treated for 16 weeks with budesonide formoterol inhaler

and patients in the experimental group were treated for 16 weeks with respiratory training on the basis of the control group. Pulmonary functions Parameters [forced vital capacity（FVC）

Forced expiratory volume in 1 second（FEV1）

FEV1/FVC]

serum biochemical parameters [interleukin（IL）-17 A

C-reactive protein（CRP）

IL-6]

blood gas analysis parameters [arterial partial pressure of oxygen（Pa O

）

arterial partial pressure of carbon dioxide（Pa CO

）]

quality of life [St. George’s Respiratory Questionnaire（SGRQ） score]

and clinical efficacy were compared between the two groups before and after treatment. Results The total effective rate of treatment in the experimental group was 95.56%

which was higher than the 80.00% in the control group

and the difference was statistically significant（P

0.05）. Before treatment

the levels of FVC

FEV1 and FEV1/FVC of the two groups were compared

and the difference was not statistically significant（P

0.05）. After treatment

the levels of FVC

FEV1 and FEV1/FVC of both groups were significantly higher than before treatment

and those in the experimental group were higher than the control group; the differences were all statistically significant（P

0.05）. Before the treatment

the Pa CO

and Pa O

levels of the 2 groups were compared

and the differences were not statistically significant（P

0.05）. After the treatment

the Pa CO

level of both groups was lower than before the treatment

the Pa O

level was higher than before the treatment

the Pa CO

level of the experimental group was lower than the control group

and the Pa O

level was higher than the control group; the differences were all statistically significant（P

0.05）. Before treatment

the serum IL-17 A

IL-6 and CRP levels of the two groups were compared

and the differences were not statistically significant（P

0.05）. After treatment

the serum IL-17 A

IL-6 and CRP levels of both groups were lower than before treatment

and those in the experimental group were lower than those in the control group; the differences were all statistically significant（P

0.05）. Before treatment

the SGRQ scores of the two groups were compared

and the differences were not statistically significant（P

0.05）. After treatment

the scores in pulmonary symptoms

mobility

and disease-influencing dimensions of both groups were lower than those before treatment

and those in the experimental group were lower than those in the control group; the differences were all statistically significant（P

0.05）. Conclusion Respiratory training combined with budesonide formoterol helps to improve the inflammatory state and lung function of patients with stable COPD and improve their quality of life

with significant clinical efficacy

and thus is worth promoting.

关键词

慢性阻塞性肺疾病呼吸训练布地奈德福莫特罗肺功能生活质量炎症因子

Keywords

Chronic obstructive pulmonary diseaseRespiratory trainingBudesonide formoterolLung functionQuality of lifeInflammatory factors

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