Objective To assess the effects of rape pollen added with selenium-enriched yeasts on immune functions in mice models

so as to provide evidence for the development of measures to enhance the immunity of populations in selenium-deficient regions.Methods Kunming mice were orally administered with rape pollen added with selenium-enriched yeasts at doses of 250

500

and 1 500 mg/kg

respectively（low-

medium-

and highdose groups）

while those control mice were administered with distilled water（negative control group）.At day30

the body mass

thymus weight

spleen weight

cellular immune function

humoral immune function

macrophage phagocytic function

and NK cell activity were measured and compared.Results The spleen weight/body mass ratio and thymus weight/body mass ratio in the low-

medium-

and high-dose groups were similar to those in the negative control group（P>0.05）.ConA-induced mouse spleen lymphocyte transformation test showed that

the optical density values in the low-and medium-dose groups were significantly higher than that in the control group（0.116±0.042 and 0.123±0.049 versus 0.075±0.031

both P<0.05）.According to the mouse peritoneal macrophage phagocytosis of chicken erythrocytes test

the phagocytic indexes in the low-

medium-

and high-dose groups were significantly higher than that in the control group（0.377±0.150

0.539±0.261 and0.403±0.113 versus 0.203±0.072

all P<0.05）;the phagocytic rates in the three dose groups were also significantly higher than that in the control group（24.0%±6.8%

28.6%±8.1%

22.6%±4.4% versus 15.2%±4.2%

all P<0.05）;the square arcsine transformation values of phagocytic rate in the three dose groups were also significantly higher than that in the control group（32.4±4.8

35.7±5.7 and 31.4±3.4 versus 25.4±3.6

all P<0.05）.Besides

the NK cell activity and its transformation values were comparable among these groups（P>0.05）.Conclusion Rape pollen mixed with selenium-enriched yeasts may improve the cellular immune function and macrophage phagocytic function

and thereby enhance immunity in mice models

which holds some promise for low-immunity populations

particularly those in selenium-deficient regions.