Objective To assess the effect of different doses of bisoprolol on the heart rate of patients diagnosed with congestive heart failure（CHF）.Methods A total of 173 patients with CHF treated at a Chongqing hospital between April 2015 and June 2016 were included in this study.Using a random number table

these patients were divided into the control group（n=42）

low-dose group（n=45）

medium-dose group（n=42）

and high-dose group（n=44）.Patients in the control group received routine treatment with diuretic+angiotensin-converting enzyme inhibitor（ACEI）+vasodilator+digoxin;while those in the low-

medium-

and highdose groups received routine treatment plus bisoprolol.The resting causal heart rate

maximal heart rate

minimal heart rate

mean heart rate

daytime mean heart rate（8:00-20:00）

and nighttime mean heart rate（20:00-8:00 of the following day）were measured and compared before treatment and at 6 months after treatment initiation.Besides

the P-R interval

QRS duration

and QT interval were also compared at 6 months.Results At 6 months

the resting causal heart rate

maximal heart rate

minimal heart rate

mean heart rate

and daytime mean heart rate were comparable between the control group and the low-dose group（P>0.05）.In the medium-and high-dose groups

the resting causal heart rate

maximal heart rate

minimal heart rate

mean heart rate

and daytime mean heart rate were significantly lower than those in the control group（P<0.05）

and the resting causal heart rate

maximal heart rate

mean heart rate

and daytime mean heart rate were significantly lower than those in the low-dose group（P<0.05）.The nighttime mean heart rate was similar among the 4 groups（P>0.05）.The resting causal heart rate

maximal heart rate

minimal heart rate

mean heart rate

and daytime mean heart rate were comparable between the medium-and high-dose groups（P>0.05）.No significant differences were noted in the P-R interval

QRS duration

and QT interval among the 4 groups（P>0.05）.Conclusion In patients with CHF

bisoprolol at a medium-or high-dose is more effective than low-dose without any increased risk for atrioventricular block.Based on these findings

medium-or high-dose bisoprolol is safe and effective in treating CHF.