Objective To detect the human papillomavirus（HPV）in 2 850 women in some areas of Zhengzhou and research the status of HPV infection and the distribution of subtype in this area.Methods In 2015 from January to December

2 850 women with sex experience examined and treated in department of gynecology hospital in Guangzhou were selected as research objects.The method of Hybrid Capture 2（HC2）generation technology was used to detect HPV infection.Results The total infection rate was 28.35%

high-risk type infection rate was 24.00%;the low risk type infection rate was 4.35%;the HPV infection of objects were mainly single infection

accounting for 88.00%

while multiple infection were mainly double infection

accounting for 9.90%;comparing the infection rate of rural area and city area and objects of different ages

the difference was statistically significant（P<0.05）.HPV infection rate of women from rural area and women of31 to 40year old were the higher;Top 5subtypes of 13high-risk HPV subtypes were type 18（26.75%）

52（15.79%）

68（12.57%）

31（9.06%）and 58（7.16%）;top 3subtypes in 5low-risk HPV subtypes were type 6（29.84%）

11（20.97%）

type 42（18.55%）.Conclusion The infection rate of women in Zhengzhou is higher and there are differences between groups of different ages.HPV infections mainly was single infection.The most common high-risk subtypes are HPV18

HPV52

HPV68

HPV31 and HPV58.The most common low-risk subtype are HPV6

HPV11

HPV42

incidence of HPV infections is higher in rural areas.