Objective To investigate the clinical value of cardioversion medicines of adenosine triphosphate（ATP）

amiodarone and propafenone in the individualized treatment of paroxysmal supraventricular tachycardia（PSVT）in children.Methods The clinical data of 126 cases of successful drug cardioversion of PSVT in children were retrospectively analyzed.According to the effect of initial cardioversion

they were divided into a first successful cardioversion group（n=95）and a multiple cardioversion group（n=31）;according to the types of medicines

the first successful cardioversion group was divided into three sub-groups:ATP（Group A

n=32）

amiodarone（Group B

n=32）and propafenone（Group C

n=31）.Group A were given rapid bolus intravenous injection of ATP

Group B were given intravenous injection of amiodarone and Group C were given intravenous injection of propafenone.Indicators of average time of cardioversion

age

gender

family genetic history

body mass index and complications in children were compared among Group A

B and C.The clinical data of the first successful cardioversion group and the multiple cardioversion group were analyzed children′s age

gender

family genetic history

body mass index and complications and adverse reactions were recorded.Results There were no statistically significant differences in gender

body mass index and family genetic history among Groups A

B and C.The shortest average time of cardioversion was（6.5±1.8）s of Group A

the shorter time was（410.6±69.4）s of Group C

the longest time was（993.5±98.4）s of Group B

and the differences among the three subgroups were statistically significant（F=18.462

P=0.000）.There were lest cases（only four cases）of children aged no more than five in Group A

there were less cases in Group C

cases of children aged no more than five in Group B were the most

and the difference was statistically significant（P<0.05）.Most of the children in Groups A and C had no complications while most of the children in Group B had complications（mostly cardiac functional insufficiency）and the difference in complications was statistically significant（P<0.05）.There were no significant differences in gender and body mass index between the first successful cardioversion group and the multiple cardioversion group but there was statistically significant difference in age between the two groups（P<0.05）.In addition

（83.9%）26cases of children of the multiple cardioversion group had complications

54.8%（17cases）had family genetic history

which were both higher than the first successful cardioversion group of 54.7%（52cases）and 26.3%（25cases）

and the differences between the two groups were statistically significant（P<0.05）.21 cases of the first successful cardioversion group had adverse reactions and the incidence was 22.1%.The incidence of adverse reactions in Group A was the highest（37.5%）

followed by Group C（25.8%）and Group B（3.1%）

and the difference among the three groups was statistically significant（P<0.05）.The incidence of adverse reactions in the multiple cardioversion group was 64.5%

significantly higher than the three subgroups（Groups A

B and C）of the first successful cardioversion group

and the difference between groups was statistically significant（P<0.05）.Conclusion The effects of the three medicines on single cardioversion are different and children with lower age

complications and family genetic history have low rate of the first successful cardioversion

which needs to be paid attention in the clinical treatment.Multiple cardioversion therapy may increase the incidence of adverse reactions and the clinician should make individualized treatment plan based on the actual condition of children with PSVT in order to improve the effect of cardioversion and improve their prognosis level.