Objective To investigate the effects of dexmedetomidine on hemodynamics in the perioperative period of interventional embolization of aneurysmal subarachnoid hemorrhage and the occurrence of secondary cerebral vasospasm.Methods 90 cases of patients with aneurysmal subarachnoid hemorrhage who had interventional embolization surgery from October 2012 to February 2015 were randomly divided into dexmedetomidine group and a control group

45 cases in each group.Patients in both groups were given the same anesthesia induction and intravenous infusion analgesia of 2

4

μg/kg of fentanyl.Patients of the control group were intermittently given 0.4

0

.6mg/kg of propofol to maintain anesthesia.Patients of dexmedetomidine group were given 0.5

0

.8μg/kg of dexmedetomidine within 15 minutes of anesthesia induction

0.2

0

.5μg/kg·h-1 of dexmedetomidine in anesthesia maintenance and 0.1

0

.2μg/kg of dexmedetomidine 10 minutes before extubation.Two groups were observed changes of mean arterial pressure（MAP）and heart rate（HR）at different time points:before operation（T0）

tracheal intubation time（T1）

before arteriocerebral angiography（T2）

10 minutes after arteriocerebral angiography（T3）

5minutes before extubation（T4）

15 minutes after extubation（T5）and they were compared their vasospasm of cerebral angiography in operation

artery blood flow velocity before and after operation and postoperative symptomatic cerebral vasospasm.Results During perioperative period

MAP and HR in patients of dexmedetomidine group had no significant change but MAP and HR in patients of the control group had significant changes.There were no significant differences of MAP and HR at T0 time point between the two groups

but the differences of MAP and HR at T1

T2

T3

and T4 time points were statistically significant（P

<

0.05）.Cerebral angiography showed 20.00% of patients in dexmedetomidine group had vasospasm in operation

lower than the control group（37.7%）and the difference was statistically significant（P

<

0.01）.The incidence of postoperative symptomatic cerebral vasospasm in dexmedetomidine group was 11.11%

lower than the control group（26.67%）and the difference between the two groups was statistically significant（P

<

0.01）.After the surgery

cerebral artery blood flow velocity of dexmedetomidine group was significantly lower than the control group and the difference was statistically significant（P

<

0.01）.Conclusion The application of dexmedetomidine in the perioperative period of interventional embolization of aneurysmal subarachnoid hemorrhage can help patients maintain hemodynamic stability and prevent the occurrence of secondary cerebral vasospasm.