Objective To analyze the reasons for failure initial therapy of community-acquired pneumonia.Method Conducted retrospective analyses by studying the 46 cases with community-acquired pneumonia

which were diagnosed as unsuccessful initial treatments

from May 2012 to June 2014 in Kunming university of science and technology.Results In those failure cases

the antimicrobial agents distribution were:cephalosporin 25cases;penicillins 13cases;fluoroquinolones 8cases;the age distribution were:11persons under age of 60（24%）

35 persons over age of 60（76%）.Conclusion It is essential to considerate mixed infection when prescribing medicine for patients with community-acquired pneumonia.Combining introduction of community-acquired pneumonia with local drug resistant situation and combining knowledge of pharmacology with own situation.Improve clinic efficiency by rational use of antimicrobial agents.