Objective To observe the clinical effect of Xiaoyao Powder combined with western medicine in the treatment of functional dyspepsia（FD）and its influence on depression and anxiety of the patients.Method 80cases of FD patients treated in out-patient and in-patient departments were selected as research object and randomly divided into experimental group and control group with 40cases in each group.Patients in the control group were treated with oral western medicine Domperidone tablets and Flupentixol and Melitracen tablets（commodity name:Deanxit）while patients in the experimental group were given Xiaoyao Powder of an increasing or decreasing dose as per symptoms on this ground with 4weeks as one course of treatment.The patients were assessed by means of Self-rating Depression Scale（SDS）and Self-Rating Anxiety Scale（SAS）before and after treatment

and the clinical effect was evaluated after one course of treatment.Results Total clinical effective rate of the experimental group was 90.0%

which was significantly higher than that of 77.5%（P<0.05）in the control group.There was no difference in depression and anxiety of patients from the two groups prior to treatment（P>0.05）

and depression and anxiety in patients from the experimental group was better than the control group after treatment（P<0.05）.Conclusion Xiaoyao Powder combined with Domperidone tablets and Deanxit can better improve depression and anxiety of FD patients and clinical effect

which is worth clinical promotion.