The infection of chronic hepatitis B virus（HBV）is a global health problem but the specific mechanism of HBV infection remains unclear.Present studies have confirmed that it is related to the virus itself

the host immune system and genetic factors.Cytokines play an important role in the prevention of virus infection and tumor necrosis factor-α（TNF-α）is a critical cytokines of host defenses and has a broad impact on innate and adaptive immune systems.Through access to relevant literature

this paper explores the correlation of four sites（-308

-238

-863

-857）of TNF-αpromoter region and HBV infection.The results show that the conclusions are different in various studies

but most of the conclusions support that TNF-αgene polymorphisms affects the susceptibility of human body to HBV.