Objective To investigate the effect of project teaching method in teaching of clinical nursing in operating room and to provide a theoretical basis for exploring suitable teaching method for intern of clinical nursing in the operating room.Method 95student nurses in the operating room were selected and divided into two groups randomly.48nurses in control group were given traditional teaching method;47nurses in experimental group were given project teaching method.Examination result and grade in assessment of nurses between the two groups were compared.Results Results of theory test and operation skills for nurses in the experimental group were（94.5±3.2）and（97.1±2.1）respectively

which in the control group were（88.1±1.5）and（90.2±3.3）respectively

and differences between the two groups were statistically significant（p<0.05）.Nurses whose grade in the assessment of comprehensive quality was excellent in the experimental group were 89.4% while those in the control group were 75.0%

which in the experimental group was higher than the control group.Conclusion Adopting project teaching method in clinical teaching in operating room can improve teaching qualities effectively.