An Analysis of the Effect of Domestic Recombinant Yeast Heptatitis B Vaccine of Different Doses

CUI Zhong-tai LIN Shu-xia YAN Yan

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An Analysis of the Effect of Domestic Recombinant Yeast Heptatitis B Vaccine of Different Doses

更新时间：2021-08-20

- An Analysis of the Effect of Domestic Recombinant Yeast Heptatitis B Vaccine of Different Doses
- Health Medicine Research and Practice Vol. 8, Issue 1, Pages: 46-47(2011)
- 作者机构：
  
  东北石油大学医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R186.3
- Published：2011，
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[1]崔忠太,林淑霞,闫岩.接种不同剂量国产重组酵母乙肝疫苗效果分析[J].保健医学研究与实践,2011,8(01):46-47+49.

CUI Zhong-tai LIN Shu-xia YAN Yan. An Analysis of the Effect of Domestic Recombinant Yeast Heptatitis B Vaccine of Different Doses. [J]. Health Medicine Research and Practice 8(1):46-47(2011)
[1]崔忠太,林淑霞,闫岩.接种不同剂量国产重组酵母乙肝疫苗效果分析[J].保健医学研究与实践,2011,8(01):46-47+49. DOI：

CUI Zhong-tai LIN Shu-xia YAN Yan. An Analysis of the Effect of Domestic Recombinant Yeast Heptatitis B Vaccine of Different Doses. [J]. Health Medicine Research and Practice 8(1):46-47(2011) DOI：

摘要

目的了解不同剂量乙肝疫苗接种的效果

对乙肝疫苗合理接种提供依据。方法将近年有乙肝疫苗全程接种史但未产生抗-HBs的学生360人

以及近年无接种史且抗-HBs阴性者469人

将两类人群各分成3组

分别进行5μg、10μg、20μg国产重组酵母乙肝疫苗的接种

全程接种后1个月

观察各组学生抗-HBs阳转情况。结果无接种史者给予3种不同剂量乙肝疫苗的全程接种

抗-HBs阳转率达85.26%、87.82%、88.54%

差异无统计学意义（P>0.05）。有接种史未产生抗体组

接种5μg

10μg

20μg 3种疫苗剂量

抗体阳转率分别为34.17%、50.83%、61.67%

10μg组和20μg组均高于5μg组

差异有统计学意义（P<0.01）

10μg组和20μg组间差异无统计学意义（P>0.05）。结论对于全程接种未产生抗-HBs者

随着剂量的增加抗-HBs的阳转率增高

建议给予10μg或20μg剂量疫苗全程再接种

一般人群给予5μg剂量疫苗即可。

Abstract

Objective To understand the results of different doses of hepatitis B vaccine in order provide references for rational vaccination.Method We divided into 3 groups 360 students who had been vaccinated with hepatitis B vaccine without HBsAb and 469 students who weren’t vaccinated with negative for HBsAb.They were vaccinated 5 μg

10 μg

20 μg respectively.They were under close inspection to observe the situation of turning positive for an HBsAb.Results The students not vaccinate before have been vaccinated 3 different doses

and positive rates of HBsAb were 85.26%

87.82%

88.54% respectively

which is of no statistical significance（P>0.05）.The students vaccinated with hepatitis B vaccine without HBsAb have been vaccinated 3 different doses

and positive rates of HBsAb were 34.17%

50.83%

61.67% respectively

which is of statistical significance（P<0.01）.Conclusion To the cases with immune tolerance

the positive rates of HBsAb rise with the increasing of the doses.So 10 μg is suggested for revaccination.And 5 μg is suitable for common cases.

关键词

高校乙肝疫苗接种效果

Keywords

collegeHepatitis B vaccineVaccinateEffect

references

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