Objective To evaluate the efficacy and safety of Pefloxacin mesylate treating with lower respiratory infections.Method 98 cases of lower respiratory infections were divided into 2 groups.The control group（43 cases）received intravehous dripping with Cefoperazone-sulbactam 2.0g;The test group（55 cases）received intravenous dripping with Pefloxacin mesylate 0.4g.The course of treatment was 7

1

0 days.Results The cure rates of test groups and the control groups were 70.91% and 72.09% respectively

and the effective rates were 96.36% and 93.02% respectively;The clearance rates of bacteria were 96.55% and 88.46% respectively;The adverse reaction rates were 5.45% and 4.65% respectively.The two groups showed no significant difference（P

>

0.05）.Conclusion The pefloxacin has good efficacy and safety for the treatment of common lower respiratory infections caused by pathogens.Therefore

it is worthy of clinical popularization.