Expression and Significance of TGF-β1 and MMP-2 in Adenomyosis

ZHAO Huan-zhi

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Expression and Significance of TGF-β1 and MMP-2 in Adenomyosis

更新时间：2021-08-23

- Expression and Significance of TGF-β1 and MMP-2 in Adenomyosis
- Health Medicine Research and Practice Vol. 6, Issue 1, Pages: 13-14(2009)
- 作者机构：
  
  重庆邮电大学医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R711.71
- Published：2009，
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[1]赵焕芝.转化生长因子-β1与基质金属蛋白酶-2在子宫腺肌病中的表达及意义[J].保健医学研究与实践,2009,6(01):13-14.

ZHAO Huan-zhi. Expression and Significance of TGF-β1 and MMP-2 in Adenomyosis. [J]. Health Medicine Research and Practice 6(1):13-14(2009)
[1]赵焕芝.转化生长因子-β1与基质金属蛋白酶-2在子宫腺肌病中的表达及意义[J].保健医学研究与实践,2009,6(01):13-14. DOI：

ZHAO Huan-zhi. Expression and Significance of TGF-β1 and MMP-2 in Adenomyosis. [J]. Health Medicine Research and Practice 6(1):13-14(2009) DOI：

摘要

目的探讨转化生长因子-β1（TGF-β1）与基质金属蛋白酶-2（MMP-2）在子宫腺肌病异位内膜中的表达情况

研究子宫腺肌病的发病机制。方法采用免疫组织化学方法检测30例子宫腺肌病异位内膜和30例正常子宫内膜中TGF-β1与MMP-2的表达。结果TGF-β1在子宫腺肌病异位内膜中及正常子宫内膜中的表达分别是（65.79±0.13）辉度、（63.22±0.65）辉度

差异有统计学意义（P<0.05）

MMP-2在子宫腺肌病异位内膜中及正常子宫内膜中表达分别为（53.98±0.64）辉度、（52.76±0.86）辉度

差异有统计学意义（P<0.05）。结论TGF-β1与MMP-2在子宫腺肌病中的表达明显增高可能促进子宫内膜在子宫肌层内异位种植和生长。

Abstract

Objective To investigate the expression of transforming growth factor-β1 （TGF-β1）and matrix metalloproteinase-2 （MMP-2） in the ectopic endometrium of adenomyoma and their relation with the pathogenesis of adenomyoma. Method Endometrial specimens were obtained from 30 normal uteri and 30 with adenomyoma. TGF-β1 and MMP-2 was detected by immunohistochemical SABC staining. Results The expression intensity of TGF-β1 in the ectopic endometrium of adenomyoma and normal endometrium were （65.79±0.13） and （63.22±0.65）. The difference had statistical significance（P<0.05）.The expressive intensity of MMP-2 in the ectopic endometrium of adenomyoma and normal endometrium were （53.98±0.64） and （52.76±0.86）. The difference had statistical significance（P<0.05）. Conclusion Overexpression of TGF-β1 and MMP-2 in ectopic endometria of adenomyoma may cause increasing local angiogenesis and enhance the growth and survival of ectopic endometrial implants.

关键词

子宫腺肌病血管生成TGF-β1MMP-2免疫组织化学

Keywords

adenomyosisAngiogenesisTransforming growth factor-β1Matrix metalloproteinase-2Immunohistochemistry

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