OBJECTIVE

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To provide reference for improving rational use of antibiotics in medical institutions.

METHODS

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With the help of information construction， strengthening personnel training and assessment， carrying out science popularization and education， optimizing drug catalogs， equipping full-time clinical pharmacists， optimizing assessment indicators and releasing pharmaceutical information in time， new fine management mode of antibiotics was constructed in our hospital. Through the hospital information system， the relevant data of our hospital in Jan.-Dec. 2020 （before the implementation） and Jan.-Dec. 2021 （after the implementation） were collected and compared， such as utilization rate of antibiotics， intensity of antimicrobial use， the incidence of hospital infection in the inpatients， the incidence of surgical site infection， the qualified rate of antibiotic medical order， and the proportion of antibiotics in the total outbound amount of Western medicine.

RESULTS

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Compared with 2020， the utilization rate of antibiotics in hospitalized patients in 2021 decreased from 34.94% to 32.44%， intensity of antimicrobial use decreased from 39.07 DDDs （defined daily doses） to 30.77 DDDs， and the incidence of nosocomial infections among inpatients decreased from 2.64% to 1.91%； the incidence of surgical site infections decreased from 0.26% to 0.03%； the qualified rate of antibiotic medical orders increased from 93.82% to 97.75%； the proportion of antibiotics in the total outbound amount of Western medicine decreased from 14.86% to 12.51%.

CONCLUSIONS

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Through a series of fine management measures， our hospital has built a new fine management mode of antibiotics， which has improved the rationality of antibiotics use while ensuring the treatment effect.