原发性干燥综合征患者唾液胱抑素D水平与唾液腺损伤的相关性分析

王静; 李飞; 黄毅; 莫凌菲; 李汉超; 潘盈; 冯秀媛; 刘新毅; 李园园

doi:10.16016/j.2097-0927.202403115

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原发性干燥综合征患者唾液胱抑素D水平与唾液腺损伤的相关性分析

临床医学 | 更新时间：2026-01-09

- 原发性干燥综合征患者唾液胱抑素D水平与唾液腺损伤的相关性分析
- Correlation between salivary cystatin D level and salivary gland injury in patients with primary Sjögren syndrome
- 陆军军医大学学报 2024年46卷第21期页码：2451-2456
- 作者机构：
  
  1.710061 西安，西安交通大学第一附属医院风湿免疫科
  2.400038 重庆，陆军军医大学(第三军医大学)生物医学分析测试中心
- 作者简介：
  
  [李园园，E-mail: wudui220@163.com LI Yuanyuan, E-mail: wudui220@163.com
- 基金信息：
  
  陕西省自然科学基础研究计划面上项目(2023-JC-YB-754)
- DOI：10.16016/j.2097-0927.202403115
  中图分类号： R442.8;R446.19;R781.7
- 收稿：2024-03-28，
  
  修回：2024-06-11，
  
  纸质出版：2024-11-15
- 稿件说明：
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王静, 李飞, 黄毅, 等. 原发性干燥综合征患者唾液胱抑素D水平与唾液腺损伤的相关性分析[J]. 陆军军医大学学报, 2024,46(21):2451-2456.

Jing WANG, Fei LI, Yi HUANG, et al. Correlation between salivary cystatin D level and salivary gland injury in patients with primary Sjögren syndrome[J]. Journal of Army Medical University, 2024, 46(21): 2451-2456.
王静, 李飞, 黄毅, 等. 原发性干燥综合征患者唾液胱抑素D水平与唾液腺损伤的相关性分析[J]. 陆军军医大学学报, 2024,46(21):2451-2456. DOI： 10.16016/j.2097-0927.202403115.

Jing WANG, Fei LI, Yi HUANG, et al. Correlation between salivary cystatin D level and salivary gland injury in patients with primary Sjögren syndrome[J]. Journal of Army Medical University, 2024, 46(21): 2451-2456. DOI： 10.16016/j.2097-0927.202403115.

摘要

目的

探讨原发性干燥综合征(primary Sjögren syndrome

pSS)患者唾液胱抑素D水平与唾液腺损伤的相关性。

方法

纳入2022年9月1日至2023年6月30日就诊于西安交通大学第一附属医院风湿免疫科pSS组患者51例及年龄、性别匹配的来院健康体检对照组人员51例。检测唾液中胱抑素D水平，采用独立样本

检验评估两组胱抑素D水平的差异，采用Pearson相关性检验评估pSS组胱抑素D与临床指标的关系。

结果

pSS组唾液中胱抑素D水平明显低于对照组(206.55±108.11

374.32±172.24 pg/mL

0.01)。pSS患者胱抑素D水平与其静态唾液流率(

=0.433

=0.002)及动态唾液流率(

=0.363

=0.009)呈正相关。高唾液腺超声检查评分的pSS患者唾液胱抑素D水平明显低于低评分患者(腮腺：160.75±85.56

290.53±95.17 pg/mL

＜0.01；颌下腺：157.76±87.59

276.25±97.06 pg/mL

＜0.01)。pSS患者胱抑素D水平与外周血IL-6水平(

=-0.453

=0.001)及CD4

T细胞计数(

=-0.396

=0.005)呈负相关。

结论

pSS患者唾液胱抑素D水平可作为反映唾液腺损伤的指标。

Abstract

Objective

To investigate the correlation between salivary cystatin D level and salivary gland injury in patients with primary Sjögren syndrome (pSS).

Methods

A total of 51 pSS patients admitted in the Department of Rheumatology and Immunology of the First Affiliated Hospital of Xi'an Jiaotong University from September 1

2022 to June 30

2023

and 51 age- and gender-matched healthy individuals who took physical examination in the hospital during same period were enrolled in the study. The

level of salivary cystatin D was detected

and the difference in the level between the 2 groups was compared using an independent-samples

test. Pearson correlation analysis was applied to analyze the correlation between salivary cystatin D and clinical parameters in the patients.

Results

The pSS patients had significantly lower cystatin D level than the healthy controls (206.55±108.11

374.32±172.24 pg/mL

0.01). The cystatin D level in the pSS patients was positively correlated with both static (

=0.433

=0.002) and dynamic salivary flow rates (

=0.363

=0.009). The patients with higher score of salivary gland ultrasonography (SGUS) had obviously lower cystatin D than those with lower SGUS score (parotid gland: 160.75±85.56

290.53±95.17 pg/mL

0.01; submandibular gland: 157.76±87.59

276.25±97.06 pg/mL

0.01). The cystatin D level was also negatively correlated with peripheral blood IL-6 level (

=-0.453

=0.001) and CD4

T cell count (

=-0.396

=0.005) in the pSS patients.

Conclusion

Salivary cystatin D level can be used as an indicator of salivary gland damage for pSS patients.

关键词

Keywords

references

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