儿童年龄相关性正常颅内压及脑灌注压阈值研究

陈小兵; 纪文元; 梁平; 翟瑄; 周建军; 程杨; 赵雪灵

doi:10.16016/j.2097-0927.202306007

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儿童年龄相关性正常颅内压及脑灌注压阈值研究

神经科学 | 更新时间：2026-01-09

- 儿童年龄相关性正常颅内压及脑灌注压阈值研究
- Study on age-related normal intracranial pressure and cerebral perfusion pressure thresholds in children
- 陆军军医大学学报 2023年45卷第21期页码：2260-2265
- 作者机构：
  
  400014 重庆，重庆医科大学附属儿童医院神经外科，儿童发育疾病研究教育部重点实验室，国家儿童健康与疾病临床医学研究中心，儿童发育重大疾病国家国际科技合作基地，儿科学重庆市重点实验室
- 作者简介：
  
  [纪文元，E-mail：282207152@qq.comJI Wenyuan, E-mail: 282207152@qq.com
- 基金信息：
  
  ‍基‍金‍项‍目‍］‍ ‍重庆市科卫联合医学科研项目(2021MSXM014);利益冲突声明所有作者声明无利益冲突;作者贡献声明陈小兵负责实施研究、采集数据、分析解释数据、统计分析和论文撰写；梁平对文章的知识性内容作批评性审阅；翟瑄、周建军参与采集数据；程杨、赵雪灵参与数据整理、统计学分析；纪文元负责研究设计、指导研究实施、参与文章撰写并修改
- DOI：10.16016/j.2097-0927.202306007
  中图分类号： R181.32;R443.5;R726.511
- 收稿：2023-06-03，
  
  修回：2023-06-10，
  
  纸质出版：2023-11-15
- 稿件说明：
移动端阅览
陈小兵, 纪文元, 梁平, 等. 儿童年龄相关性正常颅内压及脑灌注压阈值研究[J]. 陆军军医大学学报, 2023,45(21):2260-2265.

Xiaobing CHEN, Wenyuan JI, Ping LIANG, et al. Study on age-related normal intracranial pressure and cerebral perfusion pressure thresholds in children[J]. Journal of Army Medical University, 2023, 45(21): 2260-2265.
陈小兵, 纪文元, 梁平, 等. 儿童年龄相关性正常颅内压及脑灌注压阈值研究[J]. 陆军军医大学学报, 2023,45(21):2260-2265. DOI： 10.16016/j.2097-0927.202306007.

Xiaobing CHEN, Wenyuan JI, Ping LIANG, et al. Study on age-related normal intracranial pressure and cerebral perfusion pressure thresholds in children[J]. Journal of Army Medical University, 2023, 45(21): 2260-2265. DOI： 10.16016/j.2097-0927.202306007.

摘要

目的

研究不同年龄段儿童颅内压及脑灌注压相对正常参考值。

方法

回顾性分析2015年1月至2022年6月重庆医科大学附属儿童医院神经外科收治的单纯硬膜外血肿行血肿清除及颅内压监测植入患儿

术后每小时监测患儿颅内压和动脉血压

分析不同年龄组的颅内压及脑灌注压随时间、年龄的变化特点

以术后稳定期(手术72 h后)颅内压及脑灌注压值作为儿童相对正常参考值

采用百分位数法分别统计计算颅内压及脑灌注压95%范围作为参考值范围。

结果

共纳入患儿207例

其中 < 2岁组25例

2~6岁组82例

>6岁组100例。术后不同年龄组颅内压均经历短暂较低水平后迅速升高

而脑灌注压均经历短暂的较高水平

并且两者在术后12~24 h达到高峰和低谷

于术后72 h逐渐达到稳定范围。手术72 h后颅内压范围: < 2岁为3.0~8.0 mmHg

2~6岁为5.0~11.0 mmHg

>6岁为6.0~14.0 mmHg; 脑灌注压范围: < 2岁50.9~68.7 mmHg

2~6岁55.0~73.3 mmHg

>6岁57.3~79.6 mmHg。

结论

不同年龄段儿童颅内压和脑灌注压相对正常参考值范围应有所不同

建议随年龄增加而增加。

Abstract

Objective

To study the normal reference values of intracranial pressure and cerebral perfusion pressure in children of different ages.

Methods

A retrospective study was conducted on the children with simple epidural hematoma who received hematoma removal and implantation for intracranial pressure monitoring in our department from January 2015 to June 2022.The intracranial pressure and arterial blood pressure of the children were monitored per hour after surgery

and the changes in intracranial pressure and cerebral perfusion pressure were analyzed based on time and age in different age groups.The intracranial pressure and cerebral perfusion pressure in stable period (72 h after surgery) were used as the relative normal reference values

and the 95% range of intracranial pressure and cerebral perfusion pressure were calculated statistically by percentile method as the reference range.

Results

A total of 207 children were included in this study

including 25 in the < 2-year-old group

82 in the 2~6-year-old group and 100 in the >6-year-old group.Intracranial pressure in different age groups was increased rapidly after a short period of low level

while cerebral perfusion pressure experienced a short period of high level

and both reached a peak and a trough from 12 to 24 h after surgery

and gradually reached a stable range at 72 h after surgery.The range of intracranial pressure 72 h after surgery was 3.0~8.0 mmHg for the < 2-year-old group

5.0~11.0 mmHg for the 2~6-year-old group

and 6.0~14.0 mmHg for the >6-year-old group.Cerebral perfusion pressure range was 50.9~68.7

55.0~73.3

and 57.3~79.6 mmHg

respectively for the above 3 age groups.

Conclusion

The normal ranges of intracranial pressure and cerebral perfusion pressure are different in children of different ages

and we suggest increasing with age.

关键词

Keywords

references

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