信号长度对基于心率校正心率变异性分析准确性的影响

鄢苏鹏; 魏良; 龚渝顺; 胡厚源; 李永勤

doi:10.16016/j.2097-0927.202302132

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信号长度对基于心率校正心率变异性分析准确性的影响

临床医学 | 更新时间：2026-01-09

- 信号长度对基于心率校正心率变异性分析准确性的影响
- Effect of signal length during electrocardiography on accuracy of heart rate variability based on heart rate correction
- 陆军军医大学学报 2023年45卷第17期页码：1860-1868
- 作者机构：
  
  1.400038 重庆，陆军军医大学(第三军医大学)：生物医学工程与影像医学系
  2.400038 重庆，陆军军医大学(第三军医大学)：第一附属医院心血管内科
- 作者简介：
  
  [李永勤, E-mail: lyq@tmmu.edu.cnLI Yongqin, E-mail: lyq@tmmu.edu.cn
- 基金信息：
  
  国家自然科学基金面上项目(62271490)
- DOI：10.16016/j.2097-0927.202302132
  中图分类号： R312;R540.41;R542.2
- 收稿：2023-02-24，
  
  修回：2023-05-29，
  
  纸质出版：2023-09-15
- 稿件说明：
移动端阅览
鄢苏鹏, 魏良, 龚渝顺, 等. 信号长度对基于心率校正心率变异性分析准确性的影响[J]. 陆军军医大学学报, 2023,45(17):1860-1868.

Supeng YAN, Liang WEI, Yushun GONG, et al. Effect of signal length during electrocardiography on accuracy of heart rate variability based on heart rate correction[J]. Journal of Army Medical University, 2023, 45(17): 1860-1868.
鄢苏鹏, 魏良, 龚渝顺, 等. 信号长度对基于心率校正心率变异性分析准确性的影响[J]. 陆军军医大学学报, 2023,45(17):1860-1868. DOI： 10.16016/j.2097-0927.202302132.

Supeng YAN, Liang WEI, Yushun GONG, et al. Effect of signal length during electrocardiography on accuracy of heart rate variability based on heart rate correction[J]. Journal of Army Medical University, 2023, 45(17): 1860-1868. DOI： 10.16016/j.2097-0927.202302132.

摘要

目的

观察信号长度对基于心率校正心率变异性(heart rate variability，HRV)分析结果的影响，探索获得准确HRV分析所需采集信号的最短时间长度。

方法

采集2017年5月至2019年11月在陆军军医大学第一附属医院体检或就诊的116名正常对照者和72名肥厚型心肌病(hypertrophic cardiomyopathy，HCM) 患者的24 h心电数据，运用基于心率校正的HRV方法计算临床常用的9个指标。以24 h结果为标准，对比3种信号长度(5、30、60 min)计算结果的准确性和可靠性。

结果

用基于心率校正的HRV方法对3种长度的信号进行分析，HCM患者的9个HRV指标均显著低于正常对照者(

0.05)。当信号长度为5、30和60 min时，随着信号长度的增加，HRV结果和24 h结果的相关系数逐渐增大，分别为0.36±0.22、0.76±0.14和0.97±0.04 (

0.05)，和24 h结果的相对误差逐渐减小，分别为(28.09±22.96)%、(7.78±4.78)%和(3.27±1.79)% (

0.05)，受试者工作特征曲线下面积逐渐增大，分别为0.75±0.04、0.87±0.08和0.89±0.08 (

0.05)。

结论

短时HRV分析对HCM患者风险评估结果的准确性随信号长度的减小而降低。当使用基于心率校正的HRV分析方法时，获得准确结果所需采集信号的最短时间为60 min。

Abstract

Objective

To investigate the effect of different signal length during electrocardiography (ECG) on results of heart rate (HR)-corrected heart rate variability (HRV) analysis and explore the minimum time window of signal collection for accurate HRV analysis.

Methods

24-hour electrocardiogram signal were collected from 116 normal controls and 72 hypertrophic cardiomyopathy (HCM) patients admitted in the First Affiliated Hospital of Army Medical University during May 2017 to November 2019. Nine commonly used HRV metrics in clinical practice were obtained by HR-corrected HRV analysis. The HRV results of 24-hour signal length served as reference standards

and then the accuracy and reliability of HRV results at a signal length of 5

30 and 60 min were compared

respectively.

Results

In results of HR-corrected HRV analysis at 3 different signal lengths

all the 9 HRV metrics were significantly lower in the HCM patients than the normal controls (

0.05). With the increment of the signal length

the correlation coefficient between short-term HRV results and 24 h HRV results was elevated gradually (

0.05)

as 0.36±0.22

0.76±0.14

and 0.97±0.04 for the length of 5

30 and 60 min

respectively

and the relative error between short-term HRV results and 24 h HRV results was reduced (

0.05)

as (28.09±22.96)%

(7.78±4.78)%

and (3.27±1.79)% for the 3 signal lengths

with an AUC value of 0.75±0.04

0.87±0.08

and 0.89±0.08

respectively (

0.05).

Conclusion

The accuracy of short-term HRV analysis is decreased with the shortening of signal length in assessment for risk of HCM patients. For HR-corrected HRV analysis

the minimum time window of signal collection is 60 min in order to obtain accurate HRV results.

关键词

Keywords

references

YIN Y, BU J L, CUI J, et al . Changes of short-term heart rate variability and vertebral artery magnetic resonance angiography in patients with cervical Vertigo [J ] . Contrast Med ia Mol Imaging, 2022, 2022: 9551263. DOI: 10.1155/2022/9551263..

NAKAYAMA N, MIYACHI M, TAMAKOSHI K, et al . Decreased continuous sitting time increases heart rate variability in patients with cardiovascular risk factors[J ] . PLoS One, 2021, 16(6): e0253399. DOI: 10.1371/journal.pone.0253399.

MURRAY G L, COLOMBO J. Sudden cardiac death in the general population: can we improve risk stratification and prevention?[J]. Int J Angiol, 2021, 30(4): 271-276. DOI: 10.1055/s-0041-1729629.

CHENG Z Y, FANG T T, HUANG J L, et al . Hypertrophic cardiomyopathy: from phenotype and pathogenesis to treatment[J ] . Front Cardiovasc Med, 2021, 8: 722340. DOI: 10.3389/fcvm.2021.722340.

PELLI A, JUNTTILA M J, KENTTÄ T V, et al. Q waves are the strongest electrocardiographic variable associated with primary prophylactic implantable cardioverter-defibrillator benefit: a prospective multicentre study[J ] . Europace, 2022, 24(5): 774-783. DOI: 10.1093/europace/euab260.

BURTON R A B, TOMEK J, AMBROSI C M, et al . Optical interrogation of sympathetic neuronal effects on macroscopic cardiomyocy te network dynamics[J ] . iScience, 2020, 23(7): 101334. DOI: 10.1016/j.isci.2020.101334.

LI K, RVDIGER H, ZIEMSSEN T. Spectral analysis of heart rate variability: time window matters[J]. Front Neurol, 2019, 10: 545. DOI: 10.3389/fneur.2019.00545.

VOSS A, SCHROEDER R, VALLVERDÚ M, et al . Short-term vs . long-term heart rate variability in ischemic cardiomyopathy risk stratification[J ] . Front Physiol, 2013, 4: 364. DOI: 10.3389/fphys.2013.00364..

王宁馨, 张绪柘, 雷皓, 等. 功能近红外光谱技术测量短时心率变异性的准确性评估[J]. 解放军医学杂志, 2021, 46(11)1118-1122. DOI: 10.11855/j.issn.0577-7402.2021.11.09.

WANG N X, ZHANG X Z, LEI H, et al . Accuracy evauation of heart rate variability measured by functional near-infrared spectroscopy[J ] . Med JChin PLA, 2021, 46(11)1118-1122. DOI: 10.11855/j.issn.0577-7402.2021.11.09.

崔胜忠, 黄晓林, 宁新宝. 心率变异性短时分析的非平稳性影响研究[J]. 北京生物医学工程, 2010, 29(1): 35-38. DOI: 10.3969/j.issn.1002-3208.2010.01.07.

CUI S Z, HUANG X L, NING X B. The effects of non-stationary on short term analysis of heart rate variability[J]. Beijing Biomed Eng, 2010, 29(1): 35-38. DOI: 10.3969/j.issn.1002-3208.2010.01.07.

MONFREDI O, LYASHKOV A E, JOHNSEN A B, et al . Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate[J ] . Hypertension, 2014, 64(6): 1334-1343. DOI: 10.1161/HYPERTENSIONAHA.114.03782.

PLAZA-FLORIDO A, SACHA J, ALCANTARA J M. Short-term heart rate variability in resting conditions: methodological considerations[J]. Kardiol Pol, 2021, 79(7/8): 745-755. DOI: 10.33963/kp.a2021.0054.

国家心血管病专家委员会心力衰竭专业委员会, 中国医师协会心力衰竭专业委员会, 中华医学会心血管分会心力衰竭学组, 等. 中国肥厚型心肌病指南2022[J]. 中华心力衰竭和心肌病杂志, 2022, 6(2): 80-105. . DOI: 10.3760/cma.j.cn1101460-20220805-00070.

Heart Failure Committee of National Expert Committe of Cardiovascular Diseases, Chinese Heart Failure Association of Chinese Medical Doctor Association, Heart Failure Group of Chinese Society of Cardiology of Chinese Medical Association, et al . 2022 Chinese guildeline on hypertrophic cardimyopathy[J ] . Chin J Heart Fail Cardiomyopathy, 2022, 6(2): 80-105. . DOI: 10.3760/cma.j.cn1101460-20220805-00070

REENA T, RAVINDRA K, SUJATA M, et al . Analysis of heart rate variability and implication of different factors on heart rate variability[J ] . Curr Cardiol Rev, 2021, 17(5): 11-20.

SLIMANE A, ZAID A. Real-time fast Fourier transform-based Notch filter for single-frequency noise cancellation: application to electrocardiogram signal denoising[J]. J Med Signals Sens, 2021, 11(1): 52-61. DOI: 10.4103/jmss.jmss_3_20.

GUO B B, TANG H, XIA S F, et al . Development of a multi-channel wearable heart sound visualization system[J ] . J Pers Med, 2022, 12(12): 2011. DOI: 10.3390/jpm12122011.

NERI L, OBERDIER M T, AUGELLO A, et al . Algorithm for mobile platform-based real-time QRS detection[J ] . Sensors, 2023, 23(3): 1625. DOI: 10.3390/s23031625.

SCAVONE G, BARIL A A, MONTPLAISIR J, et al . Autonomic modulation during baseline and recovery sleep in adult sleepwalkers[J ] . Front Neurol, 2021, 12: 680596. DOI: 10.3389/fneur.2021.680596.

DENG S Y, WANG Q, FAN J J, et al . Correlation of circadian rhythms of heart rate variability indices with stress, mood, and sleep status in female medical workers with night shifts[J ] . Nat Sci Sleep, 2022, 14: 1769-1781. DOI: 10.2147/nss.s377762.

PERRONE M A, VOLTERRANI M, MANZI V, et al . Heart rate variability modifications in response to different types of exercise training in athletes[J ] . J Sports Med Phys Fitness, 2021, 61(10): 1411-1415. DOI: 10.23736/s0022-4707.21.12480-6.

SOLA J, VYBORNOVA A, FALLET S, et al . Validation of the optical Aktiia bracelet in different body positions for the persistent monitoring of blood pressure[J ] . Sci Rep, 2021, 11: 20644. DOI: 10.1038/s41598-021-99294-w.

CHOU E F, KHINE M, LOCKHART T, et al . Effects of ECG data length on heart rate variability among young healthy adults[J ] . Sensors, 2021, 21(18): 6286. DOI: 10.3390/s21186286.

LIU H Y, ZHAN P, SHI J L, et al . A refined method of quantifying deceleration capacity index for heart rate variability analysis[J ] . Biomed Eng Online, 2018, 17(1): 1-13. DOI: 10.1186/s12938-018-0618-x.

李京秀, 章富君, 刘娴, 等. 心率变异性的机制及其与心血管疾病的相关性研究进展[J]. 实用心电学杂志, 2021, 30(4): 293-296. . DOI: 10.13308/j.issn.2095-9354.2021.04.014

LI J X, ZHANG F J, LIU X, et al . Mechanism of heart rate variability and research advance in its relevance to cardiovascular diseases[J ] . J Pract Electrocardiol, 2021, 30(4): 2 93-296. . DOI: 10.13308/j.issn.2095-9354.2021.04.014

付生弟. 肥厚型心肌病病人心率变异性及心律失常分析[J]. 中西医结合心脑血管病杂志, 2016, 14(13): 1549-1551. DOI: 10.3969/j.issn.1672-1349.2016.13.039.

FU S D. Analysis of heart rate variability and arrhythmia in patients with hypertrophic cardiomyopathy[J]. Chin J Integr Med Cardio Cerebrovasc Dis, 2016, 14(13): 1549-1551. DOI: 10.3969/j.issn.1672-1349.2016.13.039.

MCNAMES J, ABOY M. Reliability and accuracy of heart rate variability metrics versus ECG segment duration[J]. Med Biol Eng Comput, 2006, 44(9): 747-756. DOI: 10.1007/s11517-006-0097-2.

MIGLIARO E R, CANETTI R, CONTRERAS P, et al . Heart rate variability: short-term studies are as useful as holter to differentiate diabetic patients from healthy subjects[J ] . Ann Noninvas Electrocardiol, 2003, 8(4): 313-320. DOI:10.1046/j.1542-474X.2003.08409.x.

J SACHA . Interaction between heart rate and heart rate variability . Ann Noninvasive Electrocardiol , 2014 , 19 ( 3 ): 207 - 216 .

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