重庆市本底砷暴露与男性精子质量及性激素的关联研究

李丽丽; 杨桓; 陈卿; 周妮娅; 周文正; 陈红燕; 王艺蒙; 郭瑛; 任超; 李雪; 曹佳

doi:10.16016/j.2097-0927.202212006

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重庆市本底砷暴露与男性精子质量及性激素的关联研究

专题报道：环境因素对男性生殖健康的影响及机制 | 更新时间：2026-01-09

- 重庆市本底砷暴露与男性精子质量及性激素的关联研究
- Association of background-level arsenic exposure with sperm quality and sex hormones in Chongqing males
- 陆军军医大学学报 2023年45卷第9期页码：902-910
- 作者机构：
  
  1.030001 太原，山西医科大学公共卫生学院
  2.400038 重庆，陆军军医大学(第三军医大学)军事预防医学系毒理学研究所
- 作者简介：
  
  [曹佳，E-mail: caojia1962@126.com CAO Jia, E-mail: caojia1962@126.com
- 基金信息：
  
  国家自然科学基金重点项目(82130097)
- DOI：10.16016/j.2097-0927.202212006
  中图分类号： R181.34;R321.1;R994.6
- 收稿：2022-12-01，
  
  修回：2023-02-27，
  
  纸质出版：2023-05-15
- 稿件说明：
移动端阅览
李丽丽, 杨桓, 陈卿, 等. 重庆市本底砷暴露与男性精子质量及性激素的关联研究[J]. 陆军军医大学学报, 2023,45(9):902-910.

Lili LI, Huan YANG, Qing CHEN, et al. Association of background-level arsenic exposure with sperm quality and sex hormones in Chongqing males[J]. Journal of Army Medical University, 2023, 45(9): 902-910.
李丽丽, 杨桓, 陈卿, 等. 重庆市本底砷暴露与男性精子质量及性激素的关联研究[J]. 陆军军医大学学报, 2023,45(9):902-910. DOI： 10.16016/j.2097-0927.202212006.

Lili LI, Huan YANG, Qing CHEN, et al. Association of background-level arsenic exposure with sperm quality and sex hormones in Chongqing males[J]. Journal of Army Medical University, 2023, 45(9): 902-910. DOI： 10.16016/j.2097-0927.202212006.

摘要

目的

研究青年男性人群尿总砷内暴露水平与精子质量及性激素水平的关联，评估重庆地区本底水平砷暴露对人类精子质量参数及性激素水平的潜在影响。

方法

采用广义相加模型、递归算法等方法，分析2013－2015年构建的重庆大学生男性生殖健康研究队列中703名男性大学生志愿者(18~22岁)基线尿砷浓度与精液参数、性激素水平间的关联，寻找非线性关系拐点，分析砷暴露阈值效应。横向比较本研究与国内外其他报道的尿砷中位数。

结果

尿砷水平与精子浓度、精子总数、精子DNA碎片化指数、泌乳素、卵泡刺激素、孕酮之间存在非线性关系，阈值效应分析提示，尿砷浓度与以上指标的关系均存在拐点，分别为15.17、14.17、50.97、57.51、11.36、70.44 μg/L(对数似然比检验

＜0.05)，阈值剂量以上内暴露水平与精液质量下降显著关联。与国内外相关研究报道相比

，本队列人群尿砷处于较低水平。

结论

与国内外一些地区相比，本研究人群本底尿砷水平较低，其与男性精子质量参数下降及性激素水平改变具有显著关联。

Abstract

Objective

To study the relationship of urinary total arsenic exposure level with sperm quality and sex hormone levels in young male population

and evaluate the potential impact of background arsenic exposure on parameters of sperm quality and sex hormone levels in Chongqing.

Methods

Generalized additive model and recursive algorithm were used to analyze the correlation of the baseline urine arsenic concentration with semen parameters and sex hormone levels in 703 male college students volunteers (18~22 years old) in the cohort of Chongqing college students constructed in 2013-2015. The inflection point of the nonlinear relationship was explored

and the threshold effect of arsenic exposure was analyzed. The median of urinary arsenic in this study was compared with the data from other reports at home and abroad.

Results

There was a nonlinear relationship of urine arsenic level with sperm concentration

sperm total number

sperm DNA fragment index

and levels of prolactin

follicle-stimulating hormone and progesterone. Further threshold effect analysis showed that there were inflection points of urine arsenic concentration with the above indicators

and the key points were 15.17

14.17

50.97

57.51

11.36

and 70.44 μg/L

respectively (Log-likelihood ratio test

0.05). Compared with relevant literature

the urine arsenic level was at a relatively lower level in this cohort population.

Conclusion

Compared with some regions at home and abroad

the background urine arsenic level of this study population is quite lower

and significant correlation is found in the background level with the decline of sperm quality parameters and changes in sex hormone levels.

关键词

Keywords

references

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