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肾移植术后延胡索酸水合酶缺陷型肾细胞癌1例并文献复习
Fumarate hydratase-deficient renal cell carcinoma in kidney transplant patients: one case report and literature review
- 陆军军医大学学报 2023年45卷第13期 页码：1436-1440
- 作者机构：
1.400042 重庆，陆军特色医学中心：泌尿外科
2.400042 重庆，陆军特色医学中心：病理科
- 作者简介：
[舒泽华，E-mail：2423626828@qq.com SHU Zehua, E-mail: 2423626828@qq.com
- 基金信息：
DOI：10.16016/j.2097-0927.202211139
中图分类号： R617;R737.11收稿：2022-11-18，
修回：2022-12-21，
纸质出版：2023-07-15
- 稿件说明：
移动端阅览
汪月明, 马强, 刘高磊, 等. 肾移植术后延胡索酸水合酶缺陷型肾细胞癌1例并文献复习[J]. 陆军军医大学学报, 2023,45(13):1436-1440.
Yueming WANG, Qiang MA, Gaolei LIU, et al. Fumarate hydratase-deficient renal cell carcinoma in kidney transplant patients: one case report and literature review[J]. Journal of Army Medical University, 2023, 45(13): 1436-1440.
汪月明, 马强, 刘高磊, 等. 肾移植术后延胡索酸水合酶缺陷型肾细胞癌1例并文献复习[J]. 陆军军医大学学报, 2023,45(13):1436-1440. DOI： 10.16016/j.2097-0927.202211139.
Yueming WANG, Qiang MA, Gaolei LIU, et al. Fumarate hydratase-deficient renal cell carcinoma in kidney transplant patients: one case report and literature review[J]. Journal of Army Medical University, 2023, 45(13): 1436-1440. DOI： 10.16016/j.2097-0927.202211139.
摘要
目的
2
探讨肾移植术后延胡索酸水合酶缺陷型肾细胞癌的临床特征，提高该疾病的临床诊治水平。
方法
2
本研究为回顾性研究，选取2022年3月陆军特色医学中心泌尿外科经治的1例肾移植术后延胡索酸水合酶缺陷型肾细胞癌患者作为研究对象，收集其临床资料，包括临床特点、治疗方案和预后，并复习国内外文献，针对该病例的特点进行分析和总结。
结果
2
患者女性，年龄52岁，20年前接受肾移植，诊断为右侧原肾肾癌伴远处转移，后接受减瘤性肾切除术，病理诊断为延胡索酸水合酶缺陷型肾细胞癌(根据2022版WHO肾脏肿瘤分类的修正诊断)。术后予以靶向药物治疗后因血肌酐升高停药，病情进展。
结论
2
延胡索酸水合酶缺陷型肾细胞癌进展快、预后差，诊断依赖免疫组化及基因检测。目前肾移植术后的肾癌缺乏有效的治疗手段，针对此类患者应选择个体化治疗方案。
Abstract
Objective
2
To investigate the clinical characteristics of fumarate hydratase-deficient renal cell carcinoma (FH-RCC) in kidney transplant patients so as to improve the diagnosis and treatment of the disease clinically.
Methods
2
We retrospectively analyzed and summarized the clinical data of one kidney transplanted patient with FH-RCC who was treated in the urological department of our medical center in March 2022
including clinical characteristics
treatment and prognosis. A literature review was also performed to analyze and summarize its characteristics.
Results
2
A 52-year-old female patient who received a kidney transplant 20 years ago was diagnosed with right kidney cancer with multiple metastases. Cytoreductive nephrectomy was performed and pathological type was FH-RCC based on Revised Version of WHO 2022 Classification of Renal Tumors. She then received targeted therapy until discontinuation due to elevated serum creatinine and the disease progressed rapidly.
Conclusion
2
FH-RCC is characterized by rapid progress and poor prognosis. Its diagnosis relies on immunohistochemistry and genetic test. There are no currently standard-of-care treatment options for kidney transplant patients with renal cell carcinoma. Individualized treatment regimens should be suggested for these patients.
关键词
Keywords
references
Rare Renal Cancer Cooperation Group of the Urinary and Genital Cancer Professional Committee of the Chinese Anti-Cancer Association. Consensus on clinical diagnosis and treatment of fumarate hydratase-deficient renal cell carcinoma[J]. Chin J Surg, 2022, 60(11): 961-968. DOI: 10.3760/cma.j.cn112139-20220729-00328.
PASCHALL A K, NIKPANAH M, FARHADI F, et al . Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome: spectrum of imaging findings[J ] . Clin Imaging, 2020, 68: 14-19. DOI: 10.1016/j.clinimag.2020.06.010.
MOCH H, CUBILLA A L, HUMPHREY P A, et al . The 2016 WHO classification of tumours of the urinary system and male genital organs—part A: renal, penile, and testicular tumours[J ] . Eur Urol, 2016, 70(1): 93-105. DOI: 10.1016/j.eururo.2016.02.029.
MOHANTY S K, LOBO A, CHENG L. The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges[J]. Hum Pathol, 2023, 136: 123-143. DOI: 10.1016/j.humpath.2022.08.006.
FRASCÀ G M, SANDRINI S, COSMAI L, et al . Renal cancer in kidney transplanted patients[J ] . J Nephrol, 2015, 28(6): 659-668. DOI: 10.1007/s40620-015-0219-8.
乔良伟, 王凯, 李明. 肾移植术后长期服用免疫抑制剂诱发恶性肿瘤的影响因素分析[J]. 实用癌症杂志, 2021, 36(6): 981-984. DOI: 10.3969/j.issn.1001-5930.2021.06.029.
QIAO L W, WANG K, LI M. Analysis of influencing factors of malignant tumor induced by long-term use of immunosuppressants after kidney transplantation[J]. Pract J Cancer, 2021, 36(6): 981-984. DOI: 10.3969/j.issn.1001-5930.2021.06.029.
GUPTA S,SWANSON A A, CHEN Y B, et al . Incidence of succinate dehydrogenase and fumarate hydratase-deficient renal cell carcinoma based on immunohistochemical screening with SDHA/SDHB and FH/2SC[J ] . Hum Pathol, 2019, 91: 114-122. DOI: 10.1016/j.humpath.2019.07.004.
贺大林, 薛蔚, 周芳坚, 等. 肾癌基因检测中国专家共识(2021版)[J]. 现代泌尿外科杂志, 2022, 27(3): 192-200.
HE D L, XUE W, ZHOU F J, et al . Chinese consensus on gene detection for renal cell carcinoma(2021 edition)[J ] . J Mod Urol, 2022, 27(3): 192-200.
SRINIVASAN R, SU D, STAMATAKIS L, et al . 5 Mechanism based targeted therapy for hereditary leiomyomatosis and renal cell cancer (HLRCC) and sporadic papillary renal cell carcinoma: interim results from a phase 2 study of bevacizumab and erlotinib[J ] . Eur J Cancer, 2014, 50: 8. DOI: 10.1016/S0959-8049(14)70131-5.
XU Y Z, KONG W, CAO M, et al . Genomic profiling and response to immune checkpoint inhibition plus tyrosine kinase inhibition in FH-deficient renal cell carcinoma[J ] . Eur Urol, 2023, 83(2): 163-172. DOI: 10.1016/j.eururo.2022.05.029.
GLEESON J P, NIKOLOVSKI I, DINATALE R, et al . Comprehensive molecular characterization and response to therapy in fumarate hydratase-deficient renal cell carcinoma[J ] . Clin Cancer Res, 2021, 27(10): 2910-2919. DOI: 10.1158/1078-0432.CCR-20-4367.
MANOHAR S, THONGPRAYOON C, CHEUNGPASITPORN W, et al . Systematic review of the safety of immune checkpoint inhibitors among kidney transplant patients[J ] . Kidney Int Rep, 2020, 5(2): 149-158. DOI: 10.1016/j.ekir.2019.11.015.
MANUELLI M, DE LUCA L, IARIA G, et al . Conversion to rapamycin immunosuppression for malignancy after kidney transplantation[J ] . Transplant Proc, 2010, 42(4): 1314-1316. DOI: 10.1016/j.transproceed.2010.03.051.
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