表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌治疗的研究进展及展望

姜寒水; 吴国明

doi:10.16016/j.2097-0927.202209158

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表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌治疗的研究进展及展望

专题报道：肺癌靶向治疗 | 更新时间：2026-01-09

- 表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌治疗的研究进展及展望
- Progress and prospect of epidermal growth factor receptor tyrosine kinase inhibitor in treatment of non-small cell lung cancer
- 陆军军医大学学报 2022年44卷第24期页码：2445-2452
- 作者机构：
  
  310042 杭州, 浙江省杭州市树兰(杭州)医院呼吸与危重症医学科
- 作者简介：
  
  [ 吴国明，教授，主任医师，博士研究生导师。目前担任浙江省杭州市树兰(杭州)医院呼吸与危重症医学科主任。兼任中华医学会内科学分会常委，中华医学会呼吸分会肺癌学组成员兼秘书，重庆医学会内科学分会主任委员，重庆肺癌防治联盟主席，重庆抗癌协会肺癌专委会副主任委员，重庆中西医结合协会呼吸分会副主任委员。主笔晚期非小细胞肺癌靶向治疗专家共识(2013版)。以第一/通讯作者发表论文160余篇，其中SCI论文8篇。承担国家自然基金课题1项，重庆市科委公关课题1项，面上项目1项，国家科技部973重大课题分课题1项，科技部支撑计划课题分课题2项，原卫生部行业重大专项课题分课题2项。获得军队医疗成果一等奖2项，科技进步二等奖2项，重庆市科技进步二等奖1项。主要从事肺癌的规范化和个体化治疗研究。E-mail: guoming_wu@sina.com WU Guoming, E-mail: guoming_wu@sina.com
- 基金信息：
- DOI：10.16016/j.2097-0927.202209158
  中图分类号： R734.2;R979.19
- 收稿：2022-09-17，
  
  修回：2022-11-16，
  
  纸质出版：2022-12-30
- 稿件说明：
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姜寒水, 吴国明. 表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌治疗的研究进展及展望[J]. 陆军军医大学学报, 2022,44(24):2445-2452.

Hanshui JIANG, Guoming WU. Progress and prospect of epidermal growth factor receptor tyrosine kinase inhibitor in treatment of non-small cell lung cancer[J]. Journal of Army Medical University, 2022, 44(24): 2445-2452.
姜寒水, 吴国明. 表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌治疗的研究进展及展望[J]. 陆军军医大学学报, 2022,44(24):2445-2452. DOI： 10.16016/j.2097-0927.202209158.

Hanshui JIANG, Guoming WU. Progress and prospect of epidermal growth factor receptor tyrosine kinase inhibitor in treatment of non-small cell lung cancer[J]. Journal of Army Medical University, 2022, 44(24): 2445-2452. DOI： 10.16016/j.2097-0927.202209158.

摘要

表皮生长因子受体(epidermal growth factor receptor，EGFR)突变是我国晚期非小细胞肺癌(non-small cell lung cancer，NSCLC)最常见的驱动基因，EGFR络氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitor，EGFR-TKI)已经成为其最主要的和首选的治疗方式。EGFR敏感突变主要包括19号外显子缺失(19

Del

)突变和21号外显子

858

突变，约占EGFR突变的90%，而19

Del

亚型对EGFR-TKI更加敏感和有效。对于EGFR敏感突变的晚期NSCLC患者选择任何一种在我国已经获得一线适应症的EGFR-TKI作为一线治疗都是规范的和合理的，其中奥希替尼是较优的选择。奥希替尼在早中期NSCLC术后的辅助治疗已经获得突破性进展，大大降低了疾病复发或死亡风险。未来在EGFR通路的研究重点将聚焦于克服EGFR-TKI耐药性，EGFR罕见突变抑制剂的研发和新辅助靶向治疗等。

Abstract

Epidermal growth factor receptor (EGFR) is the most common driver gene of mutations in advanced non-small cell lung cancer (NSCLC)

and EGFR tyrosine kinase inhibitor (EGFR-TKI) has become the most important and preferred treatment. EGFR-sensitive mutations mainly consist of exon 19 deletion (

19Del

) mutation and exon 21

858

mutation

accounting for about 90% of EGFR mutations

while the 19

Del

subtype is more sensitive and effective to EGFR-TKI. For advanced NSCLC patients with EGFR-sensitive mutations

it is standard and reasonable to select any EGFR-TKI which has been given first-line indications in our country as first-line treatment

among which osimertinib is a better choice. Osimertinib has made a breakthrough in the adjuvant treatment for early- and middle-stage NSCLC

and greatly reduced the risk of disease recurrence or death. Researches on EGFR pathway will focus on overcoming EGFR-TKI resistance

development of EGFR rare mutation inhibitors and neoadjuvant targeted therapy.

关键词

Keywords

references

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