瑞咯啶对脓毒症大鼠心肌损伤的保护作用

谭磊; 佘汉; 郭宁珂; 周远群; 彭小勇; 刘良明; 李涛; 毛庆祥; 胡弋

doi:10.16016/j.2097-0927.202205039

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瑞咯啶对脓毒症大鼠心肌损伤的保护作用

专题报道：战创伤休克救治 | 更新时间：2026-01-09

- 瑞咯啶对脓毒症大鼠心肌损伤的保护作用
- Protective effects of sterofundin on myocardial injury in septic rats
- 陆军军医大学学报 2022年44卷第20期页码：2054-2060
- 作者机构：
  
  1.400042 重庆，陆军特色医学中心: 麻醉科
  2.400042 重庆，陆军特色医学中心: 野战外科研究部战伤休克与输血研究室，创伤、烧伤与复合伤国家重点实验室
- 作者简介：
  
  [ 胡弋，E-mail: huyi921@sina.com HU Yi, E-mail: huyi921@sina.com
- 基金信息：
  
  国家自然科学基金重点项目(81730059)
- DOI：10.16016/j.2097-0927.202205039
  中图分类号： R542.2;R631.2;R977.7
- 收稿：2022-05-10，
  
  修回：2022-07-17，
  
  纸质出版：2022-10-30
- 稿件说明：
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谭磊, 佘汉, 郭宁珂, 等. 瑞咯啶对脓毒症大鼠心肌损伤的保护作用[J]. 陆军军医大学学报, 2022,44(20):2054-2060.

Lei TAN, Han SHE, Ningke GUO, et al. Protective effects of sterofundin on myocardial injury in septic rats[J]. Journal of Army Medical University, 2022, 44(20): 2054-2060.
谭磊, 佘汉, 郭宁珂, 等. 瑞咯啶对脓毒症大鼠心肌损伤的保护作用[J]. 陆军军医大学学报, 2022,44(20):2054-2060. DOI： 10.16016/j.2097-0927.202205039.

Lei TAN, Han SHE, Ningke GUO, et al. Protective effects of sterofundin on myocardial injury in septic rats[J]. Journal of Army Medical University, 2022, 44(20): 2054-2060. DOI： 10.16016/j.2097-0927.202205039.

摘要

目的

探讨瑞咯啶对脓毒症大鼠心肌损伤的保护作用。

方法

SPF级SD大鼠280只，雌雄各半，12~14周龄，体质量200~220 g。以随机数字表法分为4组: 假手术(Sham)组、脓毒症(sepsis，Sep)组、常规治疗(conventional treatment，Ct)组(乳酸林格液+多巴胺+头孢呋辛钠)、瑞咯啶(malate ringer’s solution

Mr)组(瑞咯啶+多巴胺+头孢呋辛钠)。采用盲肠结扎穿孔术(cecal ligation and puncture，CLP)诱导大鼠脓毒症模型，观察瑞咯啶治疗对脓毒症大鼠心肌损伤、心输出量(cardiac output，CO)、氧供氧耗、肝肾灌注、肝肾功能及存活时间、存活率的影响。

结果

Sep组大鼠心输出量、心脏指数(cardiac index，CI)、每搏指数(stroke index，SI)明显降低；Ct组大鼠CO、CI和SI有所改善(

0.05)；Mr组大鼠CO、CI和SI明显改善，与Sep组比较分别增加了48.9%、52.9%和21.7%，且明显高于Ct组(

0.05)。同样Sep组大鼠平均动脉血压明显降低，降低至70 mmHg左右；Ct组血压稍有回升到90 mmHg左右；而Mr组血压更明显改善，与Sep组比较血压增加了43.2%(

0.05)。同时与Sep组比较，Mr组大鼠肝肾器官功能明显改善，肌钙蛋白T以及乳酸脱氢酶明显降低，氧供氧耗增加，心肌间质水肿减轻和心肌纤维断裂较少，明显改善动物存活率(

0.05)。

结论

瑞咯啶能明显改善脓毒症大鼠心脏功能，发挥对脓毒症大鼠器官功能的保护作用。

Abstract

Objective

To investigate the protective effects of sterofundin on myocardial injury in septic rats.

Methods

A total of 280 SPF SD rats (half male and female

12~14 weeks old

200~220 g) were randomly divided into 4 groups: sham operation (Sham) group

sepsis (Sep) group

conventional treatment (Ct) group (with Ringer's lactate solution+dopamine+cefuroxime sodium)

and malate ringer's solution (Mr) group (with sterofundin+dopamine+cefuroxime sodium). The rat model of sepsis was inflicted by cecal ligation and puncture (CLP). Subsequently

the effects of sterofundin treatment on the myocardial injury

cardiac output (CO)

oxygen supply and consumption

liver and kidney perfusion

liver and kidney functions

survival time and survival rate of septic rats were observed.

Results

The cardiac output (CO)

cardiac index (CI) and stroke index (SI) were significantly decreased in the Sep group

while the injuries were improved to some extent in the Ct group (

0.05). As compared with the Sep group

the improvement was more obvious in the Mr group

with CO

CI and SI values increased by 48.9%

52.9% and 21.7% respectively

and the values were also greatly higher than those in the Ct group (

0.05). The mean arterial blood pressure was remarkably declined to about 70 mmHg in the Sep group

slightly improved to around 90 mmHg in the Ct group

and notably elevated in the Mr group by 43.2% when compared with the Sep group (

0.05). In addition

the liver and kidney functions were significantly ameliorated in the Mr group

along with decreased troponin T and lactate dehydrogenase

enhanced oxygen supply and consumption

alleviated myocardial interstitial edema and less myocardial fiber breakage

which greatly improved the survival rate of animals (

0.05).

Conclusion

Sterofundin obviously improves the heart function and thus plays a protective role in organ functions in septic rats.

关键词

Keywords

references

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