浏览全部资源
扫码关注微信
能谱CT容积定量参数鉴别结直肠癌病理类型的价值
Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer
- 陆军军医大学学报 2022年44卷第18期 页码：1881-1886
- 作者机构：
401120 重庆，重庆医科大学附属第三医院放射科
- 作者简介：
[曾燕，E-mail：zengyan@cqmu.edu.cn ZENG Yan, E-mail: zengyan@cqmu.edu.cn
- 基金信息：
DOI：10.16016/j.2097-0927.202204001
中图分类号： R735.35;R814.3;R814.42收稿：2022-04-01，
修回：2022-05-06，
纸质出版：2022-09-30
- 稿件说明：
移动端阅览
李晓凤, 庄羽翔, 傅浪舟, 等. 能谱CT容积定量参数鉴别结直肠癌病理类型的价值[J]. 陆军军医大学学报, 2022,44(18):1881-1886.
Xiaofeng LI, Yuxiang ZHUANG, Langzhou FU, et al. Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer[J]. Journal of Army Medical University, 2022, 44(18): 1881-1886.
李晓凤, 庄羽翔, 傅浪舟, 等. 能谱CT容积定量参数鉴别结直肠癌病理类型的价值[J]. 陆军军医大学学报, 2022,44(18):1881-1886. DOI： 10.16016/j.2097-0927.202204001.
Xiaofeng LI, Yuxiang ZHUANG, Langzhou FU, et al. Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer[J]. Journal of Army Medical University, 2022, 44(18): 1881-1886. DOI： 10.16016/j.2097-0927.202204001.
摘要
目的
2
探讨能谱CT容积定量参数对鉴别结直肠癌病理类型的临床价值。
方法
2
回顾性分析2019年1月至2021年11月在本院经病理证实的66例结直肠癌患者的临床和影像学资料，其中黏液腺癌16例，管状腺癌50例，采用不同的感兴趣区域(region of interest
ROI)获取方法测得肿瘤的容积参数和二维参数，包括碘(水)浓度、水(碘)浓度、有效原子序数，并计算出标准化碘(水)浓度(normalized iodine concentration，NIC)。采用
t
检验或Mann-Whitney
U
检验进行组间比较，对有统计学意义的参数运用ROC曲线评价其对结直肠癌病理
类型的诊断效能。
结果
2
能谱CT容积参数中，动脉期和静脉期的碘(水)浓度、NIC、有效原子序数组间差异均具有统计学意义(
P
＜0.01)；黏液腺癌的碘(水)浓度、NIC、有效原子序数均低于管状腺癌。而在二维参数中，仅静脉期的碘(水)浓度、NIC、有效原子序数组间差异具有统计学意义(
P
＜0.05)。黏液腺癌的容积碘(水)浓度和NIC低于相应二维参数。ROC曲线显示容积参数的曲线下面积均高于二维参数，其中动脉期容积NIC的诊断效能最高，其敏感度为82.0%，特异度为87.5%。
结论
2
能谱CT容积定量参数对鉴别结直肠黏液腺癌和管状腺癌较二维参数可能具有更大的潜在临床价值。
Abstract
Objective
2
To investigate the clinical value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer.
Methods
2
The clinical and imaging data of 66 patients (16 cases of mucinous adenocarcinoma and 50 cases of tubular adenocarcinoma) with colorectal cancer confirmed by pathology in our hospital from January 2019 to November 2021 were collected and retrospectively analyzed. The volume parameters and two-dimensional parameters of the tumor
including iodine (water) concentration
water (iodine) concentration and effective atomic number
were measured by different methods of region of interest (ROI) acquisition
and normalized iodine (water) concentration (NIC) was calculated. Student's
t
test or Mann-Whitney
U
test was used for comparison between groups
and receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficacy of statistically significant parameters for pathological types of colorectal cancer.
Results
2
In terms of energy spectrum volume parameters
iodine (water) concentration
NIC and Eff-Z in arterial and venous phases were significantly different (
P
<
0.01). The iodine (water) concentration
NIC and Eff-Z of mucinous adenocarcinoma were lower than those of tubular adenocarcinoma. However
in the two-dimensional parameters
only iodine (water) concentration
NIC and Eff-Z in venous phase had significant differences among grou
ps (
P
<
0.05). The volumetric iodine (water) concentration and NIC in mucinous adenocarcinoma were lower than corresponding two-dimensional parameters. ROC curve showed that the area under the curve of energy spectrum volume parameters was higher than that of two-dimensional parameters. Among them
arterial volume NIC had the highest diagnostic efficiency
with a sensitivity of 82.0% and specificity of 87.5%.
Conclusion
2
The quantitative parameters of CT volume of energy spectrum may have greater potential clinical value in differentiating mucinous colorectal adenocarcinoma from tubular adenocarcinoma than two-dimensional parameters.
关键词
Keywords
references
HORVAT N, HOPE T A, PICKHARDT P J, et al . Mucinous rectal cancer: concepts and imaging challenges[J ] . Abdom Radiol (NY), 2019, 44(11): 3569-3580. DOI: 10.1007/s00261-019-02019-x.
LI Z H, LI S, ZANG S Q, et al . Predicting treatment response to neoadjuvant chemoradiotherapy in rectal mucinous adenocarcinoma using an MRI-based radiomics nomogram[J ] . Front Oncol, 2021, 11: 671636. DOI: 10.3389/fonc.2021.671636.
CHEN J C, ZHOU L R, GAO J, et al . Clinicopathological characteristics and mutation spectrum of colorectal adenocarcinoma with mucinous component in a Chinese cohort: comparison with classical adenocarcinoma[J ] . Front Oncol, 2020, 10: 917. DOI: 10.3389/fonc.2020.00917.
GE Y X, LI J, ZHANG J Q, et al . Radiomics analysis of multicenter CT images for discriminating mucinous adenocarcinoma from nomucinous adenocarcinoma in rectal cancer and comparison with conventional CT values[J ] . J Xray Sci Technol, 2020, 28(2): 285-297. DOI: 10.3233/XST-190614.
XU J J, TAUDORF M, ULRIKSEN P S, et al . Gastrointestinal applications of iodine quantification using dual-energy CT: a systematic review[J ] . Diagnostics (Basel), 2020, 10(10): E814. DOI: 10.3390/diagnostics10100814.
AL-NAJAMI I, MAHMOUD SHETA H, BAATRUP G. Differentiation between malignant and benign rectal tumors by dual-energy computed tomography—a feasibility study[J]. Acta Oncol, 2019, 58(sup1): S55-S59. DOI: 10.1080/0284186X.2019.1574404.
李淑娟, 杨鹏飞, 鲁仁财, 等. 能谱CT诊断直肠癌浆膜外浸润[J]. 中国医学影像学杂志, 2018, 26(7): 531-534. DOI: 10.3969/j.issn.1005-5185.2018.07.013.
LI S J, YANG P F, LU R C, et al . Spectral CT diagnosis of rectal cancer pericolic infiltration[J ] . Chin J Med Imaging, 2018, 26(7): 531-534. DOI: 10.3969/j.issn.1005-5185.2018.07.013.
LI Y, LI X B, REN X Y, et al . Assessment of the aggressiveness of rectal cancer using quantitative parameters derived from dual-energy computed tomography[J ] . Clin Imaging, 2020, 68: 136-142. DOI: 10.1016/j.clinimag.2020.06.028.
陈丽红, 段青, 薛蕴菁, 等. CT能谱成像在术前评估胃癌患者病理类型的临床价值[J]. 中华放射学杂志, 2013(7): 634-637. DOI: 10.3760/cma.j.issn.1005-1201.2013.07.012.
CHEN L H, DUAN Q, XUE Y J, et al . Spectral CT characterizing the pathological type of gastric cancer[J ] . Chin J Radiol, 2013(7): 634-637. DOI: 10.3760/cma.j.issn.1005-1201.2013.07.012.
石义志. 宝石能谱CT成像对结直肠癌病理分型及与溃疡性结肠炎鉴别的应用价值[D]. 承德: 承德医学院, 2017.
SHI Y Z. The value of gemstone CT imaging in evaluating the pathological types of colorectal cancer and its application in identificating of ulcerative colitis[D]. Chengde: Chengde Medical College, 2017.
RYOO J A, KIM S S. Typical CT and MRI features of mucinous rectal adenocarcinoma[J]. J Belg Soc Radiol, 2019, 103(1): 55. DOI: 10.5334/jbsr.1910.
KIM T M, LEE J M, YOON J H, et al . Prediction of microvascular invasion of hepatocellular carcinoma: value of volumetric iodine quantification using preoperative dual-energy computed tomography[J ] . Cancer Imaging, 2020, 20(1): 60. DOI: 10.1186/s40644-020-00338-7.
钟丽娟. 能谱CT容积定量分析对鉴别肺癌病理类型的初步研究[D]. 重庆: 重庆医科大学, 2020.
ZHONG L J. Preliminary study on energy spectrum CT volume quantitative analysis to differentiate the pathological types of lung carcinoma[D]. Chongqing: Chongqing Medical University, 2020.
0
浏览量
0
下载量
0
CSCD
- 网络PDF下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 技术支持由北京北大方正电子有限公司提供 京ICP备09064830号-19
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
