3D打印技术构建含界层结构关节骨软骨支架的现状与展望

杨柳; 黄杨

doi:10.16016/j.2097-0927.202112206

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3D打印技术构建含界层结构关节骨软骨支架的现状与展望

专题报道：3D打印技术在骨关节外科的临床应用 | 更新时间：2026-01-09

- 3D打印技术构建含界层结构关节骨软骨支架的现状与展望
- Current status and perspective of 3D printing technology to construct articular osteochondral scaffolds with boundary structure
- 陆军军医大学学报 2022年44卷第15期页码：1493-1500
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院关节外科
- 作者简介：
  
  [杨柳，教授，主任医师，博士生导师，国家首批重点研发计划项目首席科学家，重庆市优秀科学家。现任关节外科精准医学重庆市重点实验室、关节生物学重庆市重点实验室主任，兼任国际软骨修复学会(ICRS)中国部常委，中国生物材料学会骨修复材料与器械分会副主任委员和关节修复材料及应用专委会副主任委员，重庆市增材制造产业协会医学3D打印分会会长，中华医学会骨科分会关节外科学组、运动医疗分会和中国医师协会运动医学分会常务委员。先后主持包括国家重点研发计划、国家自然科学基金重点项目等国家、省市及军队科研项目30余项。发表学术论文290余篇，其中SCI收录期刊论文60余篇，在Biomaterial, Bioactive Material等Q1区期刊发表论文20余篇，3篇获得Faculty Opinions(F1000)推荐。主要从事关节骨软骨再生医学、骨关节炎发病机制与防治、金属假体3D打印技术研发与应用、机器人关节外科精准重建技术等基础与临床研究。E-mail: jointsurgery@163.com YANG Liu, E-mail: jointsurgery@163.com
- 基金信息：
  
  重庆市博士后研究项目特别资助(2021XM3092)
- DOI：10.16016/j.2097-0927.202112206
  中图分类号： R319;R684
- 收稿：2021-12-23，
  
  修回：2022-05-19，
  
  纸质出版：2022-08-15
- 稿件说明：
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杨柳, 黄杨. 3D打印技术构建含界层结构关节骨软骨支架的现状与展望[J]. 陆军军医大学学报, 2022,44(15):1493-1500.

Liu YANG, Yang HUANG. Current status and perspective of 3D printing technology to construct articular osteochondral scaffolds with boundary structure[J]. Journal of Army Medical University, 2022, 44(15): 1493-1500.
杨柳, 黄杨. 3D打印技术构建含界层结构关节骨软骨支架的现状与展望[J]. 陆军军医大学学报, 2022,44(15):1493-1500. DOI： 10.16016/j.2097-0927.202112206.

Liu YANG, Yang HUANG. Current status and perspective of 3D printing technology to construct articular osteochondral scaffolds with boundary structure[J]. Journal of Army Medical University, 2022, 44(15): 1493-1500. DOI： 10.16016/j.2097-0927.202112206.

摘要

关节骨软骨缺损在临床上十分常见，组织工程技术方法可为这一病损提供具有广阔前景的再生治疗方案。关节骨软骨单元由透明软骨、钙化软骨层、软骨下骨构成，其中钙化软骨层作为关节骨与软骨的界层结构，在应力传导和微环境调控方面均具有重要作用；含有界层结构复合支架用于再生修复这类缺损是未来关节骨软骨复合组织工程的发展方向。3D打印制造技术具有快速、精准、个性化定制的优势和特点，能够满足含界层结构的关节骨软骨支架不规则几何外形与多层结构、成分差异化构建的需求。本文概述了关节骨软骨单元的形态结构、生化组分及生理功能，评述了关节骨软骨复合组织工程支架中构建其界层结构的必要性，以及利用材料挤出、熔融电写、静电纺丝、光固化和数字光处理等3D打印技术构建含界层结构骨软骨支架的方案。未来需要深入骨软骨界层结构的基础研究，并且积极开发和拓展3D打印技术在含有界层结构的关节骨软骨支架构建方面的应用，从而更好地实现骨软骨支架的功能和结构的仿生，最终提升各类伤病所致关节骨软骨缺损的再生治疗水平。

Abstract

Articular osteochondral defects are very common in clinical practice. Tissue engineering technology provides a promising treatment strategy for the disease. The articular osteochondral unit is composed of hyaline cartilage

calcified cartilage zone and subchondral bone. As the boundary structure between articular bone and cartilage

calcified cartilage zone plays an important role in stress conduction and microenvironment regulation. Composite scaffolds with boundary structure for defect repair is a development direction of osteochondral tissue engineering in the future. 3D printing technology has the advantages and characteristics of speediness

accuracy and personalized customization

which meet the needs of geometric shape

multi-layer structure and component differentiation when manufacturing osteochondral scaffold with boundary structure. We summarize the morphological structure

biochemical components and physiological functions of articular osteochondral unit

and comment on the necessity of constructing its boundary structure in articular osteochondral composite tissue engineering scaffold and its construction scheme by 3D printing technologies

such as material extrusion

melt electro-writing

electro-spinning

stereolithography

and digital light processing. Deepening the basic research of articular cartilage boundary structure and expanding the application of 3D printing technology in the construction of osteochondral scaffolds containing boundary structure will realize the bionic function and structure of osteochondral scaffold

and finally improve the regeneration treatment of articular osteochondral defects caused by various injuries.

关键词

Keywords

references

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