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肺爆炸冲击伤机制与防护研究进展
Advance of protection and mechanism of lung blast injury
- 陆军军医大学学报 2022年44卷第5期 页码：395-398
- 作者机构：
400042 重庆，陆军特色医学中心野战外科研究部战伤救治前沿技术研究室，创伤、烧伤与复合伤国家重点实验室
- 作者简介：
[ 蒋建新, 博士，研究员，博士研究生导师，中国工程院院士，创伤、烧伤与复合伤国家重点实验室主任，国家973计划项目首席科学家，国家科技支撑计划和军队重大专项首席科学家，国家杰出青年科学基金、军队杰出中青年科学基金获得者。担任亚洲创伤学会秘书长、国务院学位委员会学科评议组临床医学组成员、国家自然科学基金委员会医学部专家咨询委员会委员、中国医疗保健国际交流促进会创伤医学分会主任委员、中华组织修复与再生学会副主任委员；《中华创伤杂志》(英文版)总编辑、《中华创伤杂志》(中文版)副总编辑等。主持完成国家973计划、军队重大专项等30余项科研项目。获军队杰出专业技术人才奖、何梁何利基金科学与技术进步奖、吴阶平医药创新奖、中国科协西部开发突出贡献奖、王正国创伤医学基金终身成就奖、中华医学会创伤医学突出贡献奖、重庆市杰出英才奖等。入选新世纪国家百千万人才工程、首批军队高层次科技创新人才工程、重庆市英才优秀科学家等。获国家发明专利15项，先后获得国家科技进步二等奖4项(第一完成人2项)。发表论文327篇，被SCI收录论文120余篇；主编《创伤感染学》《爆炸冲击伤原理与实践》等7部专著。主要从事冲击伤与创伤感染方面的研究。E-mail：hellojjx@126.com JIANG Jianxin, E-mail: hellojjx@126.com
[ 曾灵，博士，副研究员，博士研究生导师。现任战伤救治前沿技术研究室副主任。入选重庆市科技英才-青年拔尖人才、陆军科技英才。主要从事爆炸冲击伤与创伤感染方面的研究。E-mail: zengling_1025@tmmu.edu.cn ZENG Ling, E-mail: zengling_1025@tmmu.edu.cn
- 基金信息：国家自然科学基金重点项目(81530063);创伤、烧伤与复合伤国家重点实验室优青人才项目(SKLYQ201901)
DOI：10.16016/j.2097-0927.202111179
中图分类号： R642;R655.3收稿：2021-11-24，
修回：2021-12-13，
纸质出版：2022-03-15
- 稿件说明：
移动端阅览
蒋建新, 曾灵. 肺爆炸冲击伤机制与防护研究进展[J]. 陆军军医大学学报, 2022,44(5):395-398.
Jianxin JIANG, Ling ZENG. Advance of protection and mechanism of lung blast injury[J]. Journal of Army Medical University, 2022, 44(5): 395-398.
蒋建新, 曾灵. 肺爆炸冲击伤机制与防护研究进展[J]. 陆军军医大学学报, 2022,44(5):395-398. DOI： 10.16016/j.2097-0927.202111179.
Jianxin JIANG, Ling ZENG. Advance of protection and mechanism of lung blast injury[J]. Journal of Army Medical University, 2022, 44(5): 395-398. DOI： 10.16016/j.2097-0927.202111179.
摘要
伴随着全球大规模和局部暴恐事件、局部冲突、易燃易爆物爆炸、煤矿瓦斯爆炸等意外事件的频发，爆炸冲击伤发生率逐年增加。肺是冲击伤中最易受累的靶器官之一，肺爆炸冲击伤发生率高、病死率高、缺乏早期有效评估手段，从而引起医学界广泛关注。肺冲击伤防护新型材料的研发、早期积极伤情评估和实时动态病情监测，对于患者防治有重要意义。笔者就肺爆炸冲击伤基础研究热点(机制、防护材料等)和临床研究热点(评估、超声诊断等)两个方面探讨肺爆炸冲击伤的临床和研究进展。
Abstract
With the frequent occurrences of global large-scale and local violent terrorist events
local conflicts
explosions of inflammable and explosive materials and coal mine gas explosion
and other accidents
the incidence of explosion impact injury is increasing every year. The lung is one of the most vulnerable target organs in blast injury. Due to its high incidence
high mortality and lack of early effective evaluation methods
lung blast injury has attracted extensive attention in the medical field. The development of new protective materials for lung blast injury
early active injury assessment and real-time dynamic disease monitoring are of great significances for the prevention and treatment of patients. Here we discuss the clinical and research progress of lung blast injury based on basic (mechanism
protective materials
etc.
) and clinical research hotspots (evaluation
ultrasonic diagnosis
etc.
).
关键词
Keywords
references
WOLF S J, BEBARTA V S, BONNETT C J, et al . Blast injuries[J ] . Lancet, 2009, 374(9687): 405-415. DOI: 10.1016/S0140-6736(09)60257-9.
ABOUDARA M, MAHONEY P F, HICKS B, et al . Primary blast lung injury at a NATO Role 3 hospital[J ] . J R Army Med Corps, 2014, 160(2): 161-166. DOI: 10.1136/jramc-2013-000216.
SCOTT T E, KIRKMAN E, HAQUE M, et al . Primary blast lung injury—a review[J ] . Br J Anaesth, 2017, 118(3): 311-316. DOI: 10.1093/bja/aew385.
LICHTENBERGER J P, KIM A M, FISHER D, et al . Imaging of combat-related thoracic trauma - blunt trauma and blast lung injury[J ] . Mil Med, 2018, 183(3/4): e89-e96. DOI: 10.1093/milmed/usx033.
ZENG L, YANG X T, LI H S, et al . The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury[J ] . Respir Res, 2016, 17(1): 164. DOI: 10.1186/s12931-016-0480-y.
CHEN F, FINE A. Stem cells in lung injury and repair[J]. Am J Pathol, 2016, 186(10): 2544-2550. DOI: 10.1016/j.ajpath.2016.05.023.
HU C, SUN J, DU J, et al . The Hippo-YAP pathway regulates the proliferation of alveolar epithelial progenitors after acute lung injury[J ] . Cell Biol Int, 2019, 43(10): 1174-1183. DOI: 10.1002/cbin.11098.
ZHOU Y, LIU T, DUAN J X, et al . Soluble epoxide hydrolase inhibitor attenuates lipopolysaccharide-induced acute lung injury and improves survival in mice[J ] . Shock, 2017, 47(5): 638-645. DOI: 10.1097/shk.0000000000000767.
YU F X, ZHAO B, PANUPINTHU N, et al . Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling[J ] . Cell, 2012, 150(4): 780-791. DOI: 10.1016/j.cell.2012.06.037.
FLINN M A, LINK B A, O'MEARA C C. Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration[J]. Semin Cell Dev Biol, 2020, 100: 11-19. DOI: 10.1016/j.semcdb.2019.09.004.
MEMTSOUDIS S G, SADOVNIKOFF N. Successful manage-ment of a trauma patient with pulmonary hemorrhage using a wire-guided bronchial blocker[J]. J Trauma, 2007, 63(6): E127-E129. DOI: 10.1097/01.ta.0000195458.68772.1f.
尹德军, 郑坚, 熊超, 等. 基于弹丸爆炸毁伤效应的复合材料与结构研究进展[J]. 材料导报, 2018, 32(5): 815-821, 827. DOI: 10.11896/j.issn.1005-023X.2018.05.018.
YIN D J, ZHENG J, XIONG C, et al . Research progress on composite materials and structures used for protection against damage effect of projectile explosion[J ] . Mater Rev, 2018, 32(5): 815-821, 827. DOI: 10.11896/j.issn.1005-023X.2018.05.018.
宋彬. 聚脲弹性体夹层防爆罐抗爆性能研究[D]. 南京: 南京理工大学, 2016.
SONG B. Study on explosion resistance of polyurea elastomer sandwich explosion-proof tank[D]. Nanjing: Nanjing University of Science and Technology, 2016.
WANG X, DU J, ZHUANG Z, et al . Incidence, casualties and risk characteristics of civilian explosion blast injury in China: 2000-2017 data from the state Administration of Work Safety[J ] . Mil Med Res, 2020, 7(1): 29. DOI: 10.1186/s40779-020-00257-5.
薛钰奇, 张华才, 文大林, 等. 模拟实爆条件下新型聚脲类材料对肺冲击伤的防护效应研究[J]. 第三军医大学学报, 2020, 42(19): 1875-1881. DOI: 10.16016/j.1000-5404.202003159.
XUE Y Q, ZHANG H C, WEN D L, et al . Bioprotective effects of novel polyurea materials on lung blast injury after simulated open-field explosion[J ] . J Third Mil Med Univ, 2020, 42(19): 1875-1881. DOI: 10.16016/j.1000-5404.202003159.
XUE Y Q, WU C S, ZHANG H C, et al . Value of lung ultrasound score for evaluation of blast lung injury in goats[J ] . Chin J Traumatol, 2020, 23(1): 38-44. DOI: 10.1016/j.cjtee.2019.11.005.
谭群友, 孙天宇, 王如文, 等. 肺部冲击伤临床诊疗规范(建议)[J]. 中华创伤杂志, 2014, 17(9): 865-867. DOI: 10.3760/cma.j.issn.1001-8050.2014.09.002.
TAN Q Y, SUN T Y, WANG R W, et al . Clinical diagnosis and treatment standards for pulmonary blast injury (Recommendation)[J ] . Chin J Trauma, 2014, 17(9): 865-867. DOI: 10.3760/cma.j.issn.1001-8050.2014.09.002.
BHAGRA A, TIERNEY D M, SEKIGUCHI H, et al . Point-of-care ultrasonography for primary care physicians and general internists[J ] . Mayo Clin Proc, 2016, 91(12): 1811-1827. DOI: 10.1016/j.mayocp.2016.08.023.
SERAPHIM A, PASCHOU S A, GRAPSA J, et al . Pocket-sized echocardiography devices: one stop shop service?[J ] . J Cardiovasc Ultrasound, 2016, 24(1): 1-6. DOI: 10.4250/jcu.2016.24.1.1.
LUI J K, BANAUCH G I. Diagnostic bedside ultrasonography for acute respiratory failure and severe hypoxemia in the medical intensive care unit: basics and comprehensive approaches[J]. J Intensive Care Med, 2017, 32(6): 355-372. DOI: 10.1177/0885066616658475.
JAMBRIK Z, MONTI S, COPPOLA V, et al . Usefulness of ultrasound lung comets as a nonradiologic sign of extravascularlung water[J ] . Am J Cardiol, 2004, 93(10): 1265-1270. DOI: 10.1016/j.amjcard.2004.02.012.
MICHARD F, SCHACHTRUPP A, TOENS C. Factors influencing the estimation of extravascular lung water by transpulmonary thermodilution in critically ill patients[J]. Crit Care Med, 2005, 33(6): 1243-1247. DOI: 10.1097/01.ccm.0000164566.23147.35.
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