Graves病患者的听力损失与发病机制探讨

胡晓霞; 王海东; 李洁; 刘霞; 党静; 竺晶; 段磊; 何继瑞; 刘晓雯

doi:10.16016/j.2097-0927.202107169

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Graves病患者的听力损失与发病机制探讨

临床医学 | 更新时间：2026-01-09

- Graves病患者的听力损失与发病机制探讨
- Hearing loss and pathogenesis in Graves' disease
- 陆军军医大学学报 2022年44卷第5期页码：489-494
- 作者机构：
  
  1.730030 兰州，兰州大学第二医院：老年病科
  2.730050 兰州，甘肃省肿瘤医院麻醉科
  3.730030 兰州，兰州大学第二医院：耳鼻喉科
- 作者简介：
  
  [ 刘晓雯，E-mail：lxw770012@126.com LIU Xiaowen, E-mail: lxw770012@126.com
- 基金信息：
  
  甘肃省自然科学基金(20JR10RA750)
- DOI：10.16016/j.2097-0927.202107169
  中图分类号： R581.1;R764.04
- 收稿：2021-07-27，
  
  修回：2021-08-24，
  
  纸质出版：2022-03-15
- 稿件说明：
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胡晓霞, 王海东, 李洁, 等. Graves病患者的听力损失与发病机制探讨[J]. 陆军军医大学学报, 2022,44(5):489-494.

Xiaoxia HU, Haidong WANG, Jie LI, et al. Hearing loss and pathogenesis in Graves' disease[J]. Journal of Army Medical University, 2022, 44(5): 489-494.
胡晓霞, 王海东, 李洁, 等. Graves病患者的听力损失与发病机制探讨[J]. 陆军军医大学学报, 2022,44(5):489-494. DOI： 10.16016/j.2097-0927.202107169.

Xiaoxia HU, Haidong WANG, Jie LI, et al. Hearing loss and pathogenesis in Graves' disease[J]. Journal of Army Medical University, 2022, 44(5): 489-494. DOI： 10.16016/j.2097-0927.202107169.

摘要

目的

研究Graves病患者的听力损失情况，探索可能的发病机制。

方法

纳入2019年9月至2021年3月在兰州大学第二医院门诊和住院部初诊的39例Graves病患者和22名健康对照受试者。HHIE-S量表初步评估受试者有无自觉听力损失，同时进行甲状腺激素和TRAB水平检测、纯音测听和声导抗检查，判断听力损失和激素水平及TRAB的相关性。

结果

HHIE-S量表显示39例Graves病患者自觉听力损失17例(43.6%)，纯音听阈阈值升高23例(59.0%)；所有受试者左右耳平均听阈无统计学差异；比较Graves病组和对照组在不同频率的阈值，除1 000 Hz外的其他频率Graves病组听阈显著高于健康对照组，差异有统计学意义(

0.05)；在4 000和8 000 Hz频率时Graves眼病组阈值明显高于Graves非眼病组(

0.01)；Graves病患者纯音听阈与甲状腺激素和TRAB无明显相关性。

结论

Graves病患者除1 000 Hz频率外，其余各检测频率均存在阈值升高而无明显自觉听力损失，合并Graves眼病时4 000和8 000 Hz高频听力损失更明显。

Abstract

Objective

To investigate the hearing loss of Graves patients and explore the possible pathogenesis.

Methods

A total of 39 Graves patients and 22 healthy control subjects who were initially admitted to the outpatient and inpatient departments of our hospital from September 2019 to March 2021 were enrolled in this study. Hearing Handicap Inventory Screening Version (HHIE-S) was used to assess whether the subjects had conscious hearing loss. Meanwhile

thyroid hormone and thyrotropin receptor antibody (TRAb) levels were detected

and pure tone audiometry and acoustic conductance were performed to judge the correlations of hearing loss with the hormone and TRAb levels.

Results

HHIE-S scale showed that 17 cases (43.6%) of 39 Graves patients had hearing loss

and 23 cases (59.0%) had increased pure tone threshold. There was no statistical difference in the average auditory threshold of all subjects. The hearing threshold was significantly higher in the Graves group than the healthy control group at frequencies other than 1 000 Hz (

0.05). At 4 000 Hz and 8 000 Hz

the thresholds of Graves eye disease group was significantly higher than that of Graves non-eye disease group (

0.01). No significant correlation was found of pure tone threshold with thyroid and TRAb levels in Graves patients.

Conclusion

Graves patients have no obvious conscious hearing loss at all detection frequencies except 1 000 Hz

and the high-frequency hearing loss at 4 000 Hz and 8 000Hz is more obvious in those with Graves eye disease.

关键词

Keywords

references

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