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1.400038 重庆,陆军军医大学(第三军医大学)基础医学院:病原生物学教研室
2.400038 重庆,陆军军医大学(第三军医大学)基础医学院:医学遗传学教研室
[徐文岳,博士,教授,博士研究生导师。担任中华预防医学会医学寄生虫学分会常务委员和全军传染病专业委员会常务委员。入选重庆市学科带头人、重庆市英才创新领军人才、“军事人力资源专业水平评价”专家。获军队育才银奖、军队特殊人才津贴,负责虫媒病防控P2+实验室的建设,主持国家自然科学基金重点项目、国家自然科学基金面上项目、军队和省部级项目10余项,在Sci Advl、J Immunol等SCI收录期刊发表论文50余篇,获得国家发明专利授权2项、军队科技进步二等奖2项。副主编或参编国家规划教材6部,参编Elsevier出版的英文专著1部。主要从事疟疾等重要虫媒病的防控应用基础研究。E-mail: xuwenyue@tmmu.edu.cn XU Wenyue, E-mail: xuwenyue@tmmu.edu.cn
收稿:2021-12-05,
修回:2021-12-13,
纸质出版:2022-01-15
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徐文岳, 徐小峰. 虫媒病防控研究与卫勤保障[J]. 陆军军医大学学报, 2022,44(1):9-15.
Wenyue XU, Xiaofeng XU. Prevention of vector-borne diseases and military medical support[J]. Journal of Army Medical University, 2022, 44(1): 9-15.
徐文岳, 徐小峰. 虫媒病防控研究与卫勤保障[J]. 陆军军医大学学报, 2022,44(1):9-15. DOI: 10.16016/j.10005404.202112035.
Wenyue XU, Xiaofeng XU. Prevention of vector-borne diseases and military medical support[J]. Journal of Army Medical University, 2022, 44(1): 9-15. DOI: 10.16016/j.10005404.202112035.
虫媒病不但是全球公共卫生问题,而且也是影响世界各国军队卫勤保障的重要问题。媒介生物的有效控制和叮咬防护手段的研制能从群体水平上控制和预防各种虫媒病的流行和传播,而针对具体虫媒病的特异性疫苗和药物的研制则能有效预防特定虫媒病的感染。虽然目前在媒介生物控制、驱避剂和疟疾疫苗研制等方面取得了显著的进展,但仍然缺乏安全、高效的虫媒病防控手段,有待于在基因驱动改造媒介生物种群、昆虫寻找宿主和机体抗虫媒病原体保护性免疫机制等方面展开深入研究。
Vector-borne diseases are not only global public health issues
but also a great concern to military medical support. Strategies to biologically control vector and prevent vector bites can protect population from infection with vector-borne diseases at community levels
and the development of effective vaccines and drugs could prevent the infection of a given important vector-borne disease. Although great progress has been achieved in the researches on vector control and repellents and malaria vaccine
highly effective measures to prevent vector-borne diseases are still lack. Therefore
it is still urgent to explore the underlying mechanism of genetic manipulation of vector populations by gene drive system
and host seeking by vectors
as well as host protective immune responses against major vector-borne diseases in the future.
PAGES F, FAULDE M, ORLANDI-PRADINES E, et al . The past and present threat of vector-borne diseases in deployed troops[J ] . Clin Microbiol Infect, 2010, 16(3): 209-224.
DAME D A, CURTIS C F, BENEDICT M Q, et al . Historical applications of induced sterilisation in field populations of mosquitoes[J ] . Malar J, 2009, 8(Suppl 2): S2. DOI: 10.1186/1475-2875-8-s2-s2.
HELINSKI M E, PARKER A G, KNOLS B G. Radiation biology of mosquitoes[J]. Malar J, 2009, 8(Suppl 2): S6. DOI: 10.1186/1475-2875-8-S2-S6.
LEES R S, GILLES J R, HENDRICHS J, et al . Back to the future: the sterile insect technique against mosquito disease vectors[J ] . Curr Opin Insect Sci, 2015, 10: 156-162. DOI: 10.1016/j.cois.2015.05.011.
LAVEN H. Eradication of Culex pipiens fatigans through cytoplasmic incompatibility[J]. Nature, 1967, 216(5113): 383-384. DOI: 10.1038/216383a0.
ZHENG X Y, ZHANG D J, LI Y J, et al . Incompatible and sterile insect techniques combined eliminate mosquitoes[J ] . Nature, 2019, 572(7767): 56-61. DOI: 10.1038/s41586-019-1407-9.
BURT A. Site-specific selfish genes as tools for the control and genetic engineering of natural populations[J]. Proc Biol Sci, 2003, 270(1518): 921-928. DOI: 10.1098/rspb.2002.2319.
HAMMOND A, GALIZI R, KYROU K, et al . A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae[J ] . Nat Biotechnol, 2016, 34(1): 78-83. DOI: 10.1038/nbt.3439.
KYROU K, HAMMOND A M, GALIZI R, et al . A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes[J ] . Nat Biotechnol, 2018, 36(11): 1062-1066. DOI: 10.1038/nbt.4245.
NIGHORN A, HILDEBRAND J G. Dissecting the molecular mechanisms of olfaction in a malaria-vector mosquito[J]. Proc Natl Acad Sci USA, 2002, 99(3): 1113-1114. DOI: 10.1073/pnas.042708099.
HALLEM E A, NICOLE FOX A, ZWIEBEL L J, et al . Olfaction: mosquito receptor for human-sweat odorant[J ] . Nature, 2004, 427(6971): 212-213. DOI: 10.1038/427212a.
JONES W D, CAYIRLIOGLU P, GRUNWALD KADOW I, et al . Two chemosensory receptors together mediate carbon dioxide detection in drosophila[J ] . Nature, 2007, 445(7123): 86-90. DOI: 10.1038/nature05466.
SCHOENIG G P, OSIMITZ T G, GABRIEL K L, et al . Evaluation of the chronic toxicity and oncogenicity of N, N-diethyl-m-toluamide (DEET)[J ] . Toxicol Sci, 1999, 47(1): 99-109. DOI: 10.1093/toxsci/47.1.99.
FREEMAN E G, WISOTSKY Z, DAHANUKAR A. Detection of sweet tastants by a conserved group of insect gustatory receptors[J]. Proc Natl Acad Sci USA, 2014, 111(4): 1598-1603. DOI: 10.1073/pnas.1311724111.
GREPPI C, LAURSEN W J, BUDELLI G, et al . Mosquito heat seeking is driven by an ancestral cooling receptor[J ] . Science, 2020, 367(6478): 681-684. DOI: 10.1126/science.aay9847.
MOLINA-CRUZ A, GARVER L S, ALABASTER A, et al . The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system[J ] . Science, 2013, 340(6135): 984-987. DOI: 10.1126/science.1235264.
MOLINA-CRUZ A, DEJONG R J, ORTEGA C, et al . Some strains of Plasmodium falciparum, a human malaria parasite, evade the complement-like system of Anopheles gambiae mosquitoes[J ] . Proc Natl Acad Sci USA, 2012, 109(28): E1957-E1962. DOI: 10.1073/pnas.1121183109.
CIRIMOTICH C M, DONG Y M, CLAYTON A M, et al . Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae[J ] . Science, 2011, 332(6031): 855-858. DOI: 10.1126/science.1201618.
PAN X, ZHOU G, WU J, et al . Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti[J ] . Proc Natl Acad Sci USA, 2012, 109(1): E23-E31. DOI: 10.1073/pnas.1116932108.
ZHU Y B, TONG L Q, NIE K X, et al . Host serum iron modulates dengue virus acquisition by mosquitoes[J ] . Nat Microbiol, 2019, 4(12): 2405-2415. DOI: 10.1038/s41564-019-0555-x.
ZHU Y, ZHANG R, ZHANG B, et al . Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system[J ] . Nat Commun, 2017, 8(1): 1262. DOI: 10.1038/s41467-017-01244-6.
DREXLER A L, PIETRI J E, PAKPOUR N, et al . Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi[J ] . PLoS Pathog, 2014, 10(6): e1004231. DOI: 10.1371/journal.ppat.1004231.
SMITH A A, NAVASA N, YANG X L, et al . Cross-species interferon signaling boosts microbicidal activity within the tick vector[J ] . Cell Host Microbe, 2016, 20(1): 91-98. DOI: 10.1016/j.chom.2016.06.001.
WANG S B, DOS-SANTOS A L A, HUANG W, et al . Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria[J ] . Science, 2017, 357(6358): 1399-1402. DOI: 10.1126/science.aan5478.
HAMMOND A M, KYROU K, BRUTTINI M, et al . The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito[J ] . PLoS Genet, 2017, 13(10): e1007039. DOI: 10.1371/journal.pgen.1007039.
PHYO A P, NKHOMA S, STEPNIEWSKA K, et al . Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study[J ] . Lancet, 2012, 379(9830): 1960-1966. DOI: 10.1016/S0140-6736(12)60484-X.
UWIMANA A, LEGRAND E, STOKES B H, et al . Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda[J ] . Nat Med, 2021, 27(6): 1113-1115. DOI: 10.1038/s41591-021-01365-y.
AGNANDJI S T, LELL B, Soulanoudjingar S S, et al . First results of phase 3 trial of RTS, S/AS01 malaria vaccine in African children[J ] . N Engl J Med, 2011, 365(20): 1863-1875. DOI: 10.1056/NEJMoa1102287.
The RTS, S Clinical Trials Partnership. A phase 3 trial of RTS, S/AS01 malaria vaccine in African infants[J]. N Engl J Med, 2012, 367(24): 2284-2295. DOI: 10.1056/nejmoa1208394.
WHO. Approves historic RTS, S malaria vaccine. [2021-10-07]. https://lenstapesmedcom/who-approves-historic-rtss-malaria-vaccine/2021.
MUELLER A K, LABAIED M, KAPPE S H, et al . Genetically modified Plasmodium parasites as a protective experimental malaria vaccine[J ] . Nature, 2005, 433(7022): 164-167. DOI: 10.1038/nature03188.
ROESTENBERG M, MCCALL M, HOPMAN J, et al . Protection against a malaria challenge by sporozoite inoculation[J ] . N Engl J Med, 2009, 361(5): 468-477. DOI: 10.1056/NEJMoa0805832.
EPSTEIN J E, TEWARI K, LYKE K E, et al . Live attenuated malaria vaccine designed to protect through hepatic CD8+ T cell immunity[J ] . Science, 2011, 334(6055): 475-480. DOI: 10.1126/science.1211548.
SEDER R A, CHANG L J, ENAMA M E, et al . Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine[J ] . Science, 2013, 341(6152): 1359-1365. DOI: 10.1126/science.1241800.
GARDNER M J, HALL N, FUNG E, et al . Genome sequence of the human malaria parasite Plasmodium falciparum[J ] . Nature, 2002, 419(6906): 498-511. DOI: 10.1038/nature01097.
KAPTEIN S J F, GOETHALS O, KIEMEL D, et al . Publisher Correction: a Pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction[J ] . Nature, 2021, 599(7883): E2. DOI: 10.1038/s41586-021-04123-9.
MOQUIN S A, SIMON O, KARUNA R, et al . NITD-688, a Pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models[J ] . Sci Transl Med, 2021, 13(579): eabb2181. DOI: 10.1126/scitranslmed.abb2181.
CAPEDING M R, TRAN N H, HADINEGORO S R, et al . Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial[J ] . Lancet, 2014, 384(9951): 1358-1365. DOI: 10.1016/S0140-6736(14)61060-6.
VILLAR L, DAYAN G H, ARREDONDO-GARCÍA J L, et al . Efficacy of a tetravalent dengue vaccine in children in Latin America[J ] . N Engl J Med, 2015, 372(2): 113-123. DOI: 10.1056/nejmoa1411037.
Dengue vaccine: WHO position paper, September 2018-recommendations[J]. Vaccine, 2019, 37(35): 4848-4849. DOI: 10.1016/j.vaccine.2018.09.063.
SIRIVICHAYAKUL C, BARRANCO-SANTANA E A, RIVERA I E, et al . Long-term safety and immunogenicity of a tetravalent dengue vaccine candidate in children and adults: a randomized, placebo-controlled, phase 2 study[J ] . J Infect Dis, 2020. DOI: 10.1093/infdis/jiaa406.
BISWAL S, BORJA-TABORA C, MARTINEZ VARGAS L, et al . Efficacyof a tetravalent dengue vaccine in healthy children aged 4-16 years: a randomised, placebo-controlled, phase 3 trial[J ] . Lancet, 2020, 395(10234): 1423-1433. DOI: 10.1016/S0140-6736(20)30414-1.
WEISKOPF D, AN GELO M A, BANGS D J, et al . The human CD8+ T cell responses induced by a live attenuated tetravalent dengue vaccine are directed against highly conserved epitopes[J ] . J Virol, 2015, 89(1): 120-128. DOI: 10.1128/jvi.02129-14.
ANGELO M A, GRIFONI A, O'ROURKE P H, et al . Human CD4 + T cell responses to an attenuated tetravalent dengue vaccine parallel those induced by natural infection in magnitude, HLA restriction, and antigen specificity[J ] . J Virol, 2017, 91(5): e02147-16. DOI: 10.1128/jvi.02147-16.
KATZELNICK L C, ZAMBRANA J V, ELIZONDO D, et al . Dengue and Zika virus infections in children elicit cross-reactive protective and enhancing antibodies that persist long term[J ] . Sci Transl Med, 2021, 13(614): eabg9478. DOI: 10.1126/scitranslmed.abg9478.
SMITH G J, VIJAYKRISHNA D, BAHL J, et al . Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic[J ] . Nature, 2009, 459(7250): 1122-1125.
WANG Z D, WANG B, WEI F, et al . A new segmented virus associated with human febrile illness in China[J ] . N Engl J Med, 2019, 380(22): 2116-2125. DOI: 10.1056/NEJMoa1805068.
ZHOU P, YANG X L, WANG X G, et al . Addendum: a pneumonia outbreak associated with a new coronavirus of probable bat origin[J ] . Nature, 2020, 588(7836): E6. DOI: 10.1038/s41586-020-2951-z.
PARRISH C R, HOLMES E C, MORENS D M, et al . Cross-species virus transmission and the emergence of new epidemic diseases[J ] . Microbiol Mol Biol Rev, 2008, 72(3): 457-470. DOI:10.1128/MMBR.00004-08.
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