温度敏感TRP通道与重大慢病的防控

祝之明; 刘道燕

doi:10.16016/j.1000-5404.202111208

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温度敏感TRP通道与重大慢病的防控

临床医学 | 更新时间：2026-01-09

- 温度敏感TRP通道与重大慢病的防控
- Thermo-sensitive TRP channels and prevention of major chronic diseases
- 陆军军医大学学报 2022年44卷第1期页码：40-49
- 作者机构：
  
  400042 重庆，陆军特色医学中心高血压内分泌科，全军高血压与代谢病中心，代谢性血管病重庆市重点实验室，重庆市高血压研究所
- 作者简介：
  
  [祝之明，博士，教授，主任医师，博士研究生导师，长江学者特聘教授, 中国高血压联盟副主席，国家自然科学基金创新研究群体牵头人。主要从事高血压、代谢综合征、原发性醛固酮增多症的发病机制研究及临床诊治。主持国家杰出青年科学基金、973计划、国家自然科学基金重点和重点国际（地区）合作研究等项目。在Circulation、Cell Metab、Cir Res、Hypertension、Diabetes等期刊发表论著150余篇。以笫一完成人获国家自然科学二等奖和国家科技进步二等奖。为Clin Sci、J Clin Hypertens、BMC Endo Dis、《中华高血压》《第三军医大学学报》等期刊副主编，Hypertension、Hypertens Res、《中华心血管病》等十余种期刊编委。E-mail: zhuzm@yahoo.com ZHU Zhiming, E-mail: zhuzm@yahoo.com
  [刘道燕，博士，研究员，主要从事高血压与代谢性心血管病的病理生理机制研究。E-mail: daoyanliu@yahoo.com LIU Daoyan, E-mail: daoyanliu@yahoo.com
- 基金信息：
  
  国家自然科学基金创新研究群体(81721001)
- DOI：10.16016/j.1000-5404.202111208
  中图分类号： R339.1;R540.1;R580.1
- 收稿：2021-11-29，
  
  修回：2021-12-11，
  
  纸质出版：2022-01-15
- 稿件说明：
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祝之明, 刘道燕. 温度敏感TRP通道与重大慢病的防控[J]. 陆军军医大学学报, 2022,44(1):40-49.

Zhiming ZHU, Daoyan LIU. Thermo-sensitive TRP channels and prevention of major chronic diseases[J]. Journal of Army Medical University, 2022, 44(1): 40-49.
祝之明, 刘道燕. 温度敏感TRP通道与重大慢病的防控[J]. 陆军军医大学学报, 2022,44(1):40-49. DOI： 10.16016/j.1000-5404.202111208.

Zhiming ZHU, Daoyan LIU. Thermo-sensitive TRP channels and prevention of major chronic diseases[J]. Journal of Army Medical University, 2022, 44(1): 40-49. DOI： 10.16016/j.1000-5404.202111208.

摘要

美国科学家David Julius和Ardem Patapoutian因辣椒素受体TRPV1和薄荷醇感受器TRPM8的突破性发现，揭示了温度感知的奥秘，由此获得了2021年诺贝尔生理学或医学奖。温度敏感性热通道TRPV1和冷通道TRPM8不仅在神经系统有丰富的表达，也存在于心血管、脂肪、肝脏和肌肉等组织器官，但其生物学意义并不清楚。近30年来，研究发现TRPV1和TRPM8除感知环境温度的变化外，还有丰富的生物学效应，如痛觉，炎症反应等，有关瞬时受体电位（transient receptor potential

TRP）通道在机体稳态调控中的作用及其与疾病关联的研究在持续增长与不断深入。我们团队自2004年较早地将TRP通道引入心血管及代谢领域，并揭示其在心血管和代谢疾病中的作用与机制。预期今年的诺奖颁发将进一步推动温度敏感通道蛋白的研究在心血管及代谢领域的发展。

Abstract

American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8

revealing the secrets of temperature perception. The outstanding discovery of capsaicin receptor TRPV1 and cold sensitive receptor TRPM8 has deepened our understanding on perception and adapt to the surrounding environment. However

thermal sensitive hot channel TRPV1 and cold channel TRPM8 are not only expressed abundantly in the nervous system

but also exist in the cardiovascular

fat

liver

skeletal muscle and other tissues and organs

and their biological significance remain elusive. In the past 30 years

much evidence shows that TRPV1 and TRPM8 not only perceive changes in environmental temperature

but also have rich biological effects

such as pain sensation

inflammatory response

and so on. Studies concerning the role of transient receptor potential (TRP) channels in the body homeostasis and its association with disease continue to grow and deepen. Since 2004

our team has introduced TRP channels into cardiovascular and metabolic fields and revealed their roles and mechanisms in cardiovascular and metabolic diseases. It is expected that this year's Nobel Prize award will further promote the development of temperature-sensitive channel proteins in cardiovascular and metabolic field.

关键词

Keywords

references

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