NLR、PLR及D-二聚体与妊娠滋养细胞肿瘤人绒毛膜促性腺激素转阴时间相关性分析

赖荔; 胡琢瑛

doi:10.16016/j.1000-5404.202106028

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NLR、PLR及D-二聚体与妊娠滋养细胞肿瘤人绒毛膜促性腺激素转阴时间相关性分析

临床医学 | 更新时间：2026-01-09

- NLR、PLR及D-二聚体与妊娠滋养细胞肿瘤人绒毛膜促性腺激素转阴时间相关性分析
- Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and D-dimer with remission time of human chorionic gonadotropin in patients with gestational trophoblastic neoplasia
- 第三军医大学学报 2021年43卷第23期页码：2596-封3
- 作者机构：
  
  400016 重庆，重庆医科大学附属第一医院妇科
- 作者简介：
  
  [胡琢瑛，E-mail: huzhuoying@sina.com HU Zhuoying, E-mail: huzhuoying@sina.com
- 基金信息：
- DOI：10.16016/j.1000-5404.202106028
  中图分类号： R446.11;R730.7;R737.33
- 收稿：2021-06-03，
  
  修回：2021-07-15，
  
  纸质出版：2021-12-15
- 稿件说明：
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赖荔, 胡琢瑛. NLR、PLR及D-二聚体与妊娠滋养细胞肿瘤人绒毛膜促性腺激素转阴时间相关性分析[J]. 第三军医大学学报, 2021,43(23):2596-封3.

Li LAI, Zhuoying HU. Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and D-dimer with remission time of human chorionic gonadotropin in patients with gestational trophoblastic neoplasia[J]. Journal of Third Military Medical University, 2021, 43(23): 2596-封3.
赖荔, 胡琢瑛. NLR、PLR及D-二聚体与妊娠滋养细胞肿瘤人绒毛膜促性腺激素转阴时间相关性分析[J]. 第三军医大学学报, 2021,43(23):2596-封3. DOI： 10.16016/j.1000-5404.202106028.

Li LAI, Zhuoying HU. Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and D-dimer with remission time of human chorionic gonadotropin in patients with gestational trophoblastic neoplasia[J]. Journal of Third Military Medical University, 2021, 43(23): 2596-封3. DOI： 10.16016/j.1000-5404.202106028.

摘要

目的

研究治疗前中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio，NLR)、淋巴细胞与血小板比值(platelet to lymphocyte ratio，PLR)、D-二聚体及临床因素与妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia，GTN)患者血人绒毛膜促性腺激素(human chorionic gonadotropin，hCG)转阴时间的相关性。

方法

选取本院2011年2月至2020年12月收治的绒毛膜癌及侵袭性葡萄胎患者共97例进行回顾性分析，平均年龄34岁，单因素及多因素分析患者年龄、前次妊娠性质、距前次妊娠终止时间、肿瘤分期、FIGO评分、化疗方案、治疗前hCG、NLR、PLR及D-二聚体与血hCG转阴时间的关系。

结果

患者hCG中位转阴时间为64 d

妊娠性质、距妊娠终止时间、FIGO评分、化疗方案、治疗前hCG、NLR、PLR及D-二聚体与hCG转阴时间相关(

0.05)，多因素分析结果显示FIGO评分高危(

=12.368)、极高危(

=4.205)，hCG≥10 000 IU/L(

=2.582)，NLR≥2.29(

=1.675)，EMA-CO方案(

=6.183)及MTX转EMA-CO方案(

=4.472)是延长转阴时间的危险因素，对EMA-CO组进行亚组分析，发现FIGO评分高危(

=7.759)、极高危(

=3.633)，hCG≥10 000 IU/L(

=2.535)，NLR≥2.29(

=2.29)是延长该亚组hCG转阴时间的独立危险因素。

结论

NLR与GTN患者血hCG转阴时间相关，治疗前NLR越高，GTN患者血hCG转阴时间越长。

Abstract

Objective

To investigate the correlation of pre-treatment neutrophil-to-lymphocyte ratio (NLR)

platelet-to-lymphocyte ratio (PLR)

D-dimer level and other clinical factors with the time to serum human chorionic gonadotropin (hCG) remission in patients with gestational trophoblastic neoplasia (GTN).

Methods

A total of 97 patients (mean age: 34 years) with GTN admitted to our hospital from February 2011 to December 2020 were enrolled and their clinical data were retrospectively analyzed. Univariate and multivariate analyses were performed to investigate the correlation between hCG remission time with factors such as age

antecedent pregnancy

interval time from previous pregnancy

tumor stage

FIGO score

chemotherapy regimen

serum hCG level

NLR

PLR and D-dimer before treatment.

Results

Among the included patients

the median time to hCG remission was 64 d. The antecedent pregnancy

inter

val time from previous pregnancy

FIGO score

chemotherapy regimen

pre-treatment hCG level

NLR

PLR and D-dimer were all proved to be correlated with hCG remission time (

0.05). Multivariate analysis confirmed that high-risk FIGO score (

=12.368)

extremely high-risk FIGO score (

=4.205)

hCG level ≥10 000 IU/L (

=2.582)

NLR≥2.29 (

=1.675)

chemotherapy with EMA-CO regimen (

=6.183) and changing MTX regimen to EMA-CO regimen (

=4.472) were independent risk factors for extended time to hCG remission. Subgroup analysis on the patients with initial EMA-CO regimen revealed that high-risk FIGO score (

=7.759)

extremely high-risk FIGO score (

=3.633)

pre-treatment hCG≥10 000 IU/L (

=2.535) and NLR≥2.29 (

=2.29) were also the independent risk factors for extended hCG remission time in this group.

Conclusion

NLR is related to the remission time for hCG in GTN patients. The higher pre-treatment hCG is

the longer hCG remission time.

关键词

Keywords

references

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