着眼瘢痕防治，促进创面愈合

颜洪

doi:10.16016/j.1000-5404.202104094

您当前的位置：

首页 >

文章列表页 >

着眼瘢痕防治，促进创面愈合

专题报道：皮肤创面与瘢痕修复研究 | 更新时间：2026-01-09

- 着眼瘢痕防治，促进创面愈合
- Focus on scar prevention and treatment, promote wound healing
- 第三军医大学学报 2021年43卷第11期页码：997-1002
- 作者机构：
  
  646000 四川泸州，西南医科大学附属医院整形烧伤外科，国家临床重点建设专科，创面修复与再生实验室
- 作者简介：
  
  [颜洪，博士，主任医师，教授，博士生导师。担任中华医学会烧伤外科学分会青年委员，中国医师协会显微外科医师分会委员，中国医疗整形美容协会瘢痕医学分会委员，中国医疗保健国际交流促进会生物物理与再生修复医学分会委员，中国康复医学会修复重建外科专业委员会全国委员；四川省整形专业委员会常委，西南五省一市烧伤整形学术委员会常委，四川省医学会烧伤外科专业侯任主任委员；《中华烧伤杂志》编委。主持包含国家自然科学基金青年科学基金项目和面上项目等各级科研项目5项。共发表临床与科研论文50余篇。E-mail: huaxi90@126.com YAN Hong, E-mail: huaxi90@126.com
- 基金信息：
- DOI：10.16016/j.1000-5404.202104094
  中图分类号： R619.6
- 收稿：2021-04-15，
  
  修回：2021-04-29，
  
  纸质出版：2021-06-15
- 稿件说明：
移动端阅览
颜洪. 着眼瘢痕防治，促进创面愈合[J]. 第三军医大学学报, 2021,43(11):997-1002.

Hong YAN. Focus on scar prevention and treatment, promote wound healing[J]. Journal of Third Military Medical University, 2021, 43(11): 997-1002.
颜洪. 着眼瘢痕防治，促进创面愈合[J]. 第三军医大学学报, 2021,43(11):997-1002. DOI： 10.16016/j.1000-5404.202104094.

Hong YAN. Focus on scar prevention and treatment, promote wound healing[J]. Journal of Third Military Medical University, 2021, 43(11): 997-1002. DOI： 10.16016/j.1000-5404.202104094.

摘要

皮肤损伤后，创面的愈合和瘢痕的治疗就成为患者的痛点和医务者工作的重点。理清创面愈合的正常程序，在创面不同的阶段予以合适的处理，维护创面愈合正常程序，以此减少瘢痕的形成，减轻患者的痛苦。现对创面愈合的程序进行简要回顾，总结临床创面修复、瘢痕治疗技术的现状、存在的问题以及进展，期望在不远的将来，有更多的新技术应用在创面修复的不同时期，让创面无疤痕愈合。

Abstract

After skin injury

wound healing and scar treatment has become the pain point of patients and the focus of medical workers. We need to clarify the normal procedure of wound healing

give appropriate treatment at different stages and maintain the normal procedure of wound healing

so as to reduce the formation of scar and relieve the pain of patients. This paper briefly reviewed the procedure of wound healing and summarized the current situation and existing problems of clinical wound healing and scar treatment. We expect that in the near future

more and more new technologies will be applied for different stages of wound repair

so that the wound will heal without scars.

关键词

Keywords

references

O'LOUGHLIN A, KULKARNI M, CREANE M, et al . Topical administration of allogeneic mesenchymal stromal cells seeded in a collagen scaffold augments wound healing and increases angiogenesis in the diabetic rabbit ulcer[J ] . Diabetes, 2013, 62(7): 2588-2594.

BREM H. Molecular markers in patients with chronic wounds to guide surgical debridement[J]. Mol Med, 2007, 13(1/2): 30-39.

SEN C K, GORDILLO G M, ROY S, et al . Human skin wounds: a major and snowballing threat to public health and the economy[J ] . Wound Repair Regen, 2009, 17(6): 763-771.

HAN G, CEILLEY R. Chronic wound healing: a review of current management and treatments[J]. Adv Ther, 2017, 34(3): 599-610.

TARTARINI D, MELE E. Adult stem cell therapies for wound healing: biomaterials and computational models[J]. Front Bioeng Biotechnol, 2015, 3: 206.

HASSAN W U, GREISER U, WANG W. Role of adipose-derived stem cells in wound healing[J]. Wound Repair Regen, 2014, 22(3): 313-325.

FRYKBERG R G, BANKS J. Challenges in the treatment of chronic wounds[J]. Adv Wound Care (New Rochelle), 2015, 4(9): 560-582.

EL AYADI A, JAY J W, PRASAI A. Current approaches targeting the wound healing phases to attenuate fibrosis and scarring[J]. Int J Mol Sci, 2020, 21(3): 1105.

BEHRANGI E, GOODARZI A, ROOHANINASAB M, et al . A review of scar treatment related to acne and burn[J ] . J Crit Rev, 2020, 7: 714-722.

WILGUS T A, ROY S, MCDANIEL J C. Neutrophils and wound repair: positive actions and negative reactions[J]. Adv Wound Care (New Rochelle), 2013, 2(7): 379-388.

HE L, MARNEROS A G. Macrophages are essential for the early wound healing response and the formation of a fibrovascular scar[J]. Am J Pathol, 2013, 182(6): 2407-2417.

WILLENBORG S, LUCAS T, VAN LOO G, et al . CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair[J ] . Blood, 2012, 120(3): 613-625.

DONATI G, ROGNONI E, HIRATSUKA T, et al . Wounding induces dedifferentiation of epidermal Gata6 + cells and acquisition of stem cell properties[J ] . Nat Cell Biol, 2017, 19(6): 603-613..

BLANPAIN C, HORSLEY V, FUCHS E. Epithelial stem cells: turning over new leaves[J]. Cell, 2007, 128: 445-458.

FUCHS E. Finding one's niche in the skin[J]. Cell Stem Cell, 2009, 4(6): 499-502.

DARBY I A, LAVERDET B, BONTÉ F, et al . Fibroblasts and myofibroblasts in wound healing[J ] . Clin Cosmet Investig Dermatol, 2014, 7: 301-311.

GILL S E, PAPE M C, KHOKHA R, et al . A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis[J ] . Dev Biol, 2003, 261(2): 313-323.

TELGENHOFF D, SHROOT B. Cellular senescence mechanisms in chronic wound healing[J]. Cell Death Differ, 2005, 12(7): 695-698.

冯光, 宋达疆, 章一新, 等. 创面修复临床研究进展[J]. 中国美容整形外科杂志, 2019, 30(11): 687-689, 后插7.

FENG G, SONG D J, ZHANG Y X, et al . Progress in clinical research of wound repair[J ] . Chin J Aesthetic Plastic Surg, 2019, 30(11): 687-689, Back Insert 7.

KAHL M, GÖKÇEN A, FISCHER S, et al . Maggot excretion products from the blowfly Lucilia sericata contain contact phase/intrinsic pathway-like proteases with procoagulant functions[J ] . Thromb Haemost, 2015, 114(2): 277-288.

ORGILL D P, BAYER L R. Negative pressure wound therapy: past, present and future[J]. Int Wound J, 2013, 10(Suppl 1): 15-19.

GO M L, OR M, VAN GOETHEM B. Negative pressure wound therapy: the past and the future[J]. Vlaams Diergeneeskundig Tijdschrift, 2017, 86(3): 127-135.

JI Q, WANG P, HE C. Extracorporeal shockwave therapy as a novel and potential treatment for degenerative cartilage and bone disease: Osteoarthritis. A qualitative analysis of the literature[J]. Prog Biophys Mol Biol, 2016, 121(3): 255-265.

SCHADEN W, THIELE R, KÖLPL C, et al . Shock wave therapy for acute and chronic soft tissue wounds: a feasibility study[J ] . J Surg Res, 2007, 143(1): 1-12.

CHOU W Y, WANG C J. Extended extracorporeal shockwave therapy for chronic diabetic foot ulcers: A case series[J]. Wounds, 2019, 31(5): 132-136.

COOPER B, BACHOO P. Extracorporeal shock wave therapy for the healing and management of venous leg ulcers[J]. Cochrane Database Syst Rev, 2018, 6(6): CD011842.

吴天宇, 郭莹. 氦氖激光联合体外冲击波治疗压疮[J]. 当代临床医刊, 2018, 31(4): 3988, 3983.

WU T Y, GUO Y. Treatment of pressure sore with He-Ne laser combined with extracorporeal shock wave[J]. Med J Ind Enterp, 2018, 31(4): 3988, 3983.

张丽, 付小兵. FDA批准体外冲击波疗法(ESWT)的新适应证: 用于糖尿病足溃疡创面的治疗[J]. 感染. 炎症. 修复, 2017, 18(4): 204.

ZHANG L, FU X B. FDA approves a new indication for extracorporeal shock wave therapy (ESWT) : for the treatment of diabetic foot ulcer wounds[J]. Infect Inflam Repair, 2017, 18(4): 204.

HIGUERA G A, VAN BOXTEL A, VAN BLITTERSWIJK C A, et al . The physics of tissue formation with mesenchymal stem cells[J ] . Trends Biotechnol, 2012, 30(11): 583-590.

AGLIALORO F, ABAY A, YAGCI N, et al . Mechanical stress induces Ca 2+ -dependent signal transduction in erythroblasts and modulates erythropoiesis[J ] . Int J Mol Sci, 2021, 22(2): 955..

SUNDARAM S, SELLAMUTHU K, NAGAVELU K, et al . Stimulation of angiogenesis using single-pulse low-pressure shock wave treatment[J ] . J Mol Med (Berl), 2018, 96(11): 1177-1187.

HAYASHI D, KAWAKAMI K, ITO K, et al . Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: a critical role of endothelial nitric oxide synthase[J ] . Wound Repair Regen, 2012, 20(6): 887-895.

KUO Y R, WANG C T, WANG F S, et al . Extracorporeal shock-wave therapy enhanced wound healing via increasing topical blood perfusion and tissue regeneration in a rat model of STZ-induced diabetes[J ] . Wound Repair Regen, 2009, 17(4): 522-530..

KUO Y R, WANG C T, WANG F S, et al . Extracorporeal shock wave treatment modulates skin fibroblast recruitment and leukocyte infiltration for enhancing extended skin-flap survival[J ] . Wound Repair Regen, 2009, 17(1): 80-87.

MORTON L M, DOVER J S, PHILLIPS T J, et al . Treatment of ulcers with ablative fractional lasers[J ] . Semin Cutan Med Surg, 2015, 34(1): 37-41.

NODZO S R, TOBIAS M, AHN R, et al . Electrical stimulation combined with antibiotics treats periprosthetic joint infection[C ] . Orlando: American Academy of Orthopaedic Surgeons, 2016.

刘元波, 唐茂林. 穿支皮瓣的历史、演变和给予我们的启示[J]. 中华整形外科杂志, 2018, 34(9): 681-687.

LIU Y B, TANG M L. History, evolution and enlightenment of perforator flap[J]. Chin J Plastic Surg, 2018, 34(9): 681-687.

OWLER M A, RUSH E W, RICHARDSON M K, et al . Randomized, prospective, blinded-enrollment, head-to-head venous leg ulcer healing trial comparing living, bioengineered skin graft substitute (Apligraf) with living, cryopreserved, human skin allograft (TheraSkin)[J ] . Clin Podiatric Med Surg, 2018, 35(3): 357-365.

ZHANG Y X, HAYAKAWA T J, LEVIN L S, et al . The economy in autologous tissue transfer: part 1. the kiss flap technique[J ] . Plast Reconstr Surg, 2016, 137(3): 1018-1030.

WANG X, YOU C, HU X, et al . The roles of knitted mesh-reinforced collagen-chitosan hybrid scaffold in the one-step repair of full-thickness skin defects in rats[J ] . Acta Biomater, 2013, 9(8): 7822-7832.

KIM S, LEE S, KIM H, et al . Exosomes secreted from induced pluripotent stem cell-derived mesenchymal stem cells accelerate skin cell proliferation[J ] . Int J Mol Sci, 2018, 19(10): 3119.

ULLAH S, MANSOOR S, AYUB A, et al . An update on stem cells applications in burn wound healing[J ] . Tissue Cell, 2021, 72: 101527.

OJEH N, PASTAR I, TOMIC-CANIC M, et al . Stem cells in skin regeneration, wound healing, and their clinical applications[J ] . Int J Mol Sci, 2015, 16: 25476-25501.

OCHIAI H, KISHI K, KUBOTA Y, et al . Transplanted mesenchymal stem cellsare effective for skin regeneration in acute cutaneous wounds of pigs[J ] . Regen Ther, 2017, 7: 8-16.

MOTEGI S I, ISHIKAWA O. Mesenchymal stem cells: The roles and functions in cutaneous wound healing and tumor growth[J]. J Dermatol Sci, 2017, 86(2): 83-89.

NOURIAN DEHKORDI A, MIRAHMADI BABAHEYDARI F, CHEHELGERDI M, et al . Skin tissue engineering: wound healing based on s tem-cell-based therapeutic strategies[J ] . Stem Cell Res Ther, 2019, 10(1): 111.

MARFIA G, NAVONE S E, DI VITO C, et al . Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds[J ] . Organogenesis, 2015, 11(4): 183-206.

RODGERS K, JADHAV S S. The application of mesenchymal stem cells to treat thermal and radiation burns[J]. Adv Drug Deliv Rev, 2018, 123: 75-81.

ALAPURE B V, LU Y, HE M, et al . Accelerate healing of severe burn wounds by mouse bone marrow mesenchymal stem cell-seeded biodegradable hydrogel scaffold synthesized from arginine-based poly(ester amide) and chitosan[J ] . Stem Cells Dev, 2018, 27(23): 1605-1620.

WAN J, XIA L, LIANG W, et al . Transplantation of bone marrow-derived mesenchymal stem cells promotes delayed wound healing in diabetic rats[J ] . J Diabetes Res, 2013, 2013: 647107.

KANJI S, DAS H. Advances of stem cell therapeutics in cutaneous wound healing and regeneration[J]. Mediators Inflamm, 2017, 2017: 5217967.

NG W L, WANG S, YEONG W Y, et al . Skin bioprinting: impending reality or fantasy?[J ] . Trends Biotechnol, 2016, 34(9): 689-699.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

超声清创联合负压吸引对痛风石破溃创面疗效的随机对照研究

咖啡因对小鼠皮肤伤口愈合和愈后瘢痕的影响

负压封闭引流技术在创面植皮中的应用

OPN诱导小鼠MSCs向表皮细胞分化促进创面愈合的研究

小鼠皮肤创伤后创面局部真皮干细胞参与修复过程