4种近红外脑氧仪模拟4 500 m高海拔环境的检测效果对比

彭滔滔; 任玉坤; 詹剑; 杨觅; 龙宗泓; 左都坤; 刘华为; 段振馨; 李钰; 李洪

doi:10.16016/j.1000-5404.202103201

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4种近红外脑氧仪模拟4 500 m高海拔环境的检测效果对比

临床医学 | 更新时间：2026-01-09

- 4种近红外脑氧仪模拟4 500 m高海拔环境的检测效果对比
- Detection effects of 4 near-infrared cerebral oximeters: a comparative study in simulated high altitude (4 500 m)
- 第三军医大学学报 2021年43卷第18期页码：1813-1820
- 作者机构：
  
  400037 重庆，陆军军医大学(第三军医大学)第二附属医院麻醉科
- 作者简介：
  
  [李洪，E-mail：lh78553@126.com LI Hong, E-mail: lh78553@126.com
- 基金信息：
  
  国家重点研发计划(2018YFC0117200)
- DOI：10.16016/j.1000-5404.202103201
  中图分类号： R197.39;R339.54;R443.8
- 收稿：2021-03-23，
  
  修回：2021-05-07，
  
  纸质出版：2021-09-30
- 稿件说明：
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彭滔滔, 任玉坤, 詹剑, 等. 4种近红外脑氧仪模拟4 500 m高海拔环境的检测效果对比[J]. 第三军医大学学报, 2021,43(18):1813-1820.

Taotao PENG, Yukun REN, Jian ZHAN, et al. Detection effects of 4 near-infrared cerebral oximeters: a comparative study in simulated high altitude (4 500 m)[J]. Journal of Third Military Medical University, 2021, 43(18): 1813-1820.
彭滔滔, 任玉坤, 詹剑, 等. 4种近红外脑氧仪模拟4 500 m高海拔环境的检测效果对比[J]. 第三军医大学学报, 2021,43(18):1813-1820. DOI： 10.16016/j.1000-5404.202103201.

Taotao PENG, Yukun REN, Jian ZHAN, et al. Detection effects of 4 near-infrared cerebral oximeters: a comparative study in simulated high altitude (4 500 m)[J]. Journal of Third Military Medical University, 2021, 43(18): 1813-1820. DOI： 10.16016/j.1000-5404.202103201.

摘要

目的

评价INVOS 5100C(美敦力)、EGOS-600(爱琴)和MNIR-P100(名希)、BRS-1(中科博锐)等4种近红外脑氧仪在高海拔环境中的检测效果。

方法

2021年3月3日~2021年3月16日招募到陆军军医大学男性健康志愿者174名，年龄18~22岁、身高(172.8±5.1)cm、BMI(22.5±2.2)kg/m

，用随机数字表法将受试者分为6组，每组29人，分别在平原(海拔300 m)和模拟4 500 m海拔高度时采用4种近红外脑氧仪随机依次测量受试者的脑氧饱和度(regional cerebral oxygen saturation，rcSO

)，记录仪器的响应时间、受试者的血压(blood pressure，BP)、心率(heart rate，HR)、脉搏氧饱和度(pulse oxygen saturation，SPO

)，对比4种仪器检测响应时间、rcSO

检测值之间的差异和一致性、rcSO

与SpO

之间的相关性。

结果

① 4种脑氧仪在4 500 m高原环境中检测成功率均为100%。INVOS 5100C、EGOS-600、MNIR-P100、BRS-1在平原响应时间分别为(2.13±0.34)s、(6.60±1.23)s、(2.87±0.48)s、(2.65±0.47)s，在高原响应时间分别为(2.22±0.41)、(6.83±1.25)、(2.86±0.49)、(2.67±0.49)s，其中EGOS-600的响应时间较其余3种仪器平均延长3 s以上(

0.05)。MNIR-P100和BRS-1的响应时间与平原相比无显著差异(

0.05)，INVOS 5100C和EGOS-600的响应时间与平原相比分别平均增加了约0.1 s和0.2 s(

0.05)。②在平原(300 m)BRS-1和INVOS 5100C的rcSO

测量值一致性较EGOS-600和MNIR-P100更好，在模拟4500 m海拔高度，EGOS-600和INVOS 5100C的rcSO

测量值一致性较BRS-1和MNIR-P100更好。受试者从平原至模拟高原环境时，BRS-1与INVOS 5100C测量rcSO

下降幅度一致性比EGOS-600和MNIR-P100更好。③当INVOS

5100C达到以rcSO

测量值下降超过基础值的20%为脑缺氧干预指标时，EGOS-600、MNIR-P100、BRS-1分别有78%、94%、76%的受试者未达到；当INVOS 5100C达到rcSO

为50%绝对阈值作为脑缺氧干预指标时，EGOS-600、MNIR-P100、BRS-1分别有52.9%、54.6%、54.3%的受试者未达到。④INVOS 5100C、EGOS-600、MNIR-P100、BRS-1测量rcSO

与SpO

Abstract

Objective

To evaluate the detection effects of 4 brands of near-infrared cerebral oximeters (NICOs)

INVOS 5100C (Medtronic)

EGOS-600 (Aegean)

MNIR-P100 (Mingxi) and BRS-1 (Casibrain Technology) in high-altitude environment.

Methods

From March 3

2021 to March 16

2021

a total of 174 healthy male volunteers (18~22 years old

172.8±5.1 cm

BMI 22.5±2.2 kg/m

) were subjected from Army Medical University

and then randomly divided into 6 groups (n=29). Their regional cerebral oxygen saturation (rcSO

)

instrument response time

blood pressure (BP)

heart rate (HR)

and pulse oxygen saturation (SPO

) were recorded and compared in the plain (300 m) and the 4 500-m altitude environment. The correlations among the above indicators were evaluated by Pearson correlation analysis. The difference and consistency of above indicators by the 4 devices were investigated.

Results

① The effective detection rates of all 4 NICOs were 100% in 4 500 m environment. In the plain environment

the response time was 2.13±0.34

6.60±1.23

2.87±0.48 and 2.65±0.47 s for INVOS 5100C

EGOS-600

MNIR-P100 and BRS-1

respectively

while the time was 2.22±0.41

6.83±1.25

2.86±0.49 and 2.67±0.49 s respectively in the 4 500-m altitude environment. EGOS-600 had the longest response time

with mo

re than 3 s longer than the other 3 NICOs (

0.05). There was no obvious difference in the response time in MNIR-P100 and BRS-1 between the plain and high altitude environment (

0.05). But the response time of INVOS 5100C and EGOS-600 was increased by 0.1 and 0.2 s respectively in the 4 500 m altitude environment than the plain (

0.05). ②In the plain environment

INVOS 5100C and BRS-1 showed better consistency in rcSO

detection than EGOS-600 and MNIR-P100. While in the 4 500 m altitude environment

EGOS-600 and INVOS 5100C performed better consistency than BRS-1 and MNIR-P100. When the subjects entered from the plain to 4 500 m altitude environment

the decline range showed better consistency in BRS-1 and INVOS 5100C than EGOS-600 and MNIR-P100. ③When taking the decline range of rcSO

reaching 20% as the intervention value of cerebral hypoxia

78%

94% and 76% of the subjects respectively detected by EGOS-600

MNIR-P100 and BRS-1 were under the threshold. When taking the decline range of rcSO

reaching 50% as the intervention value of cerebral hypoxia

52.9%

54.6% and 54.3% of the subjects respectively detected by EGOS-600

MNIR-P100 and BRS-1 were under the threshold. ④The correlation coefficients of SpO

and rcSO

detected by INVOS 5100C

EGOS-600

MNIR-P100 and BRS-1 were 0.876 4 (

0.000 1)

0.641 7 (

0.000 1)

0.761 8 (

0.000 1) and 0.6525 (

0.0001)

respectively.

Conclusion

In terms of rcSO

INVOS 5100C shows great consistency with the 3 domestic NICOs

and the 3 domestic instruments also show great specificity but less good sensitivity.

关键词

Keywords

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