觉醒发生系统研究进展与思考

胡志安; 夏建霞

doi:10.16016/j.1000-5404.202102164

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觉醒发生系统研究进展与思考

专题报道：意识障碍的基础与临床研究 | 更新时间：2026-01-09

- 觉醒发生系统研究进展与思考
- Wakefulness-promoting systems: progress and thinking
- 第三军医大学学报 2021年43卷第15期页码：1408-1417
- 作者机构：
  
  400038，重庆，陆军军医大学(第三军医大学)基础医学院生理学教研室，脑与智能研究院
- 作者简介：
  
  [ "胡志安，博士，教授，博士研究生导师。陆军军医大学基础医学院生理学教研室主任，脑与智能研究院执行院长。担任中国睡眠研究会副理事长和中国神经科学会常务理事。为国家自然科学基金创新研究群体牵头人。主持国家重点基础研究发展计划(973计划)子课题、军委科技委国防科技创新特区重点项目、陆军军医大学军事医学创新预研基金重点项目等项目4项。获得中国人民解放军院校育才奖金奖。以通信作者在Science、Journal of Neuroscience、Cerebral Cortex、Progress in Neurobiology等SCI收录的期刊上发表论著50余篇。主要从事觉醒睡眠神经机制方面的研究。E-mail: zhianhu@aliyun.com" ]
  [ "夏建霞，博士，副教授，主要从事觉醒睡眠的神经机制方面的研究。E-mail：xiajxia@163.com" ]
- 基金信息：
  
  国家自然科学基金创新研究群体项目(31921003);国家自然科学基金面上项目(31571046)
- DOI：10.16016/j.1000-5404.202102164
  中图分类号： R338.6
- 收稿：2021-02-28，
  
  修回：2021-03-23，
  
  纸质出版：2021-08-15
- 稿件说明：
移动端阅览
胡志安, 夏建霞. 觉醒发生系统研究进展与思考[J]. 第三军医大学学报, 2021,43(15):1408-1417.

Zhi HU, Jianxia XIA. Wakefulness-promoting systems: progress and thinking[J]. Journal of Third Military Medical University, 2021, 43(15): 1408-1417.
胡志安, 夏建霞. 觉醒发生系统研究进展与思考[J]. 第三军医大学学报, 2021,43(15):1408-1417. DOI： 10.16016/j.1000-5404.202102164.

Zhi HU, Jianxia XIA. Wakefulness-promoting systems: progress and thinking[J]. Journal of Third Military Medical University, 2021, 43(15): 1408-1417. DOI： 10.16016/j.1000-5404.202102164.

摘要

觉醒是生命的真实呈现。一直以来，觉醒研究的焦点主要是觉醒发生的神经机制。近年来

随着单细胞活动标记和检测技术的快速发展及在神经科学领域中的广泛应用，觉醒发生的神经环路机制不断得到更新和完善。除了经典的胆碱能、单胺能类等神经递质系统参与觉醒的发生外，神经肽能、谷氨酸能及γ-氨基丁酸能等神经递质系统也被发现是觉醒发生系统的重要组成部分。同时，有新的观点认为，觉醒既涉及促觉醒核团本身，也与觉醒发生系统支配的脑功能网络状态密不可分。觉醒不能的发生既可能源于觉醒发生系统受损，也可能源于关键的脑功能网络自身受损。因此，从脑功能网络状态出发，系统阐释觉醒发生系统与脑功能网络的内在关系，才能更好地理解觉醒的本质。

Abstract

Wakefulness is the real presentation of life. All the time

the neural mechanism of wakefulness has been the focus of its researches. With the development of single cell labeling and detection technologies and their wide application in the field of neurosciences

the mechanism of neural circuit for wakefulness has been continuously updated and improved. In recent years

more evidence demonstrates that except the classical cholinergic and monoamine neurotransmitter systems

other neurotransmitters are also the important components involved in the regulation of wakefulness

such as neuropeptides

glutamate and γ-aminobutyric acid. There is a new idea that wakefulness involves not only the wakefulness-promoting systems

but also the brain function network innervated by the systems. Only if the damage to the wakefulness-promoting system or to the core functional brain network itself

would not wakefulness occur. Therefore

from the perspective of the functional needs of the brain

we will better understand the nature of wakefulness.

关键词

Keywords

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