人群研究在慢性非传染性疾病精准医学中的应用

吴涛; 王斯悦

doi:10.16016/j.1000-5404.202102120

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人群研究在慢性非传染性疾病精准医学中的应用

专题报道：常见慢性非传染性疾病的预防与控制 | 更新时间：2026-01-09

- 人群研究在慢性非传染性疾病精准医学中的应用
- Application of population-based studies for precision medicine in chronic non-communicable diseases
- 第三军医大学学报 2021年43卷第12期页码：1089-1096
- 作者机构：
  
  100191 北京，北京大学公共卫生学院流行病与卫生统计学系
- 作者简介：
  
  吴涛，博士，教授，博士生导师。毕业于美国约翰霍普金斯大学公共卫生学院流行病学系。现任北京大学公共卫生学院流行病与卫生统计学系副主任。中国医药教育协会精准健康管理专业委员会常务委员，中华口腔医学会口腔遗传病与罕见病专委会委员，北京癌症防治学会精准预防专业委员会副主任委员, 《中华流行病学杂志》编委。主要研究领域为遗传流行病学、慢性病流行病学、精准医学。作为项目负责人承担国家自然科学基金项目，北京市自然科学基金面上项目，卫生部行业基金项目子课题等多项研究。近年来发表SCI收录论文、中文核心期刊论文近百篇。E-mail: twu@bjmu.edu.cn
- 基金信息：
- DOI：10.16016/j.1000-5404.202102120
  中图分类号： R181.1;R181.2;R181.3
- 收稿：2021-02-25，
  
  修回：2021-03-16，
  
  纸质出版：2021-06-30
- 稿件说明：
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吴涛, 王斯悦. 人群研究在慢性非传染性疾病精准医学中的应用[J]. 第三军医大学学报, 2021,43(12):1089-1096.

Tao WU, Siyue WANG. Application of population-based studies for precision medicine in chronic non-communicable diseases[J]. Journal of Third Military Medical University, 2021, 43(12): 1089-1096.
吴涛, 王斯悦. 人群研究在慢性非传染性疾病精准医学中的应用[J]. 第三军医大学学报, 2021,43(12):1089-1096. DOI： 10.16016/j.1000-5404.202102120.

Tao WU, Siyue WANG. Application of population-based studies for precision medicine in chronic non-communicable diseases[J]. Journal of Third Military Medical University, 2021, 43(12): 1089-1096. DOI： 10.16016/j.1000-5404.202102120.

摘要

精准医学基于个体生物、环境与生活方式暴露特征，探索个体化的疾病预防与治疗策略。常见慢性非传染性疾病大多是受遗传及环境因素共同影响的复杂疾病，多数病因尚不完全清晰。利用多组学技术，人群研究能够为精准医学在慢性病中的应用提供研究证据。人群研究的结果可以辅助揭示疾病发生发展的机制，协助疾病亚型分类，优化疾病风险预测模型，完善差异化的诊断、治疗方案及预防控制策略措施的制定，最终改善人群健康水平。

Abstract

Precision medicine aims at tailored disease prevention and treatment strategies based on individualized exposure

including biological status

environment and lifestyle

etc

. Common chronic non-communicable diseases involve a complex interplay of both genetic and environmental factors

while most of their etiologies remain unknown. With advances in multi-omics

population-based studies can contribute to the practice of precision medicine in control of chronic diseases by providing research evidence. Results from population-based studies can be beneficial to reveal etiology and pathogenesis from a population level

assist in more detailed phenotype classification

optimize disease risk prediction by better identifying high risk populations and improve targeted diagnosis

treatments

prevention and control strategies for different individuals

and ultimately promote public health standard.

关键词

Keywords

references

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