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超声波导入维生素E对面部Ⅱ度烧伤患者色素沉着的近期疗效分析
Efficacy of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn: a short-term analysis
- 第三军医大学学报 2021年43卷第11期 页码：1039-1044
- 作者机构：
646000 四川 泸州，西南医科大学附属医院整形烧伤外科，国家临床重点建设专科，创面修复与再生实验室
- 作者简介：
[颜洪，E-mail: huaxi90@126.com YAN Hong, E-mail: huaxi90@126.com
- 基金信息：
DOI：10.16016/j.1000-5404.202101072
中图分类号： R364.23;R644;R977.25收稿：2021-01-08，
修回：2021-03-10，
纸质出版：2021-06-15
- 稿件说明：
移动端阅览
杨茹茜, 王雪, 杨雨婷, 等. 超声波导入维生素E对面部Ⅱ度烧伤患者色素沉着的近期疗效分析[J]. 第三军医大学学报, 2021,43(11):1039-1044.
Ruqian YANG, Xue WANG, Yuting YANG, et al. Efficacy of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn: a short-term analysis[J]. Journal of Third Military Medical University, 2021, 43(11): 1039-1044.
杨茹茜, 王雪, 杨雨婷, 等. 超声波导入维生素E对面部Ⅱ度烧伤患者色素沉着的近期疗效分析[J]. 第三军医大学学报, 2021,43(11):1039-1044. DOI： 10.16016/j.1000-5404.202101072.
Ruqian YANG, Xue WANG, Yuting YANG, et al. Efficacy of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn: a short-term analysis[J]. Journal of Third Military Medical University, 2021, 43(11): 1039-1044. DOI： 10.16016/j.1000-5404.202101072.
摘要
目的
2
观察超声波导入维生素E对面部Ⅱ度烧伤后色素沉着的治疗效果。
方法
2
招募2019年9月至2020年9月在本院就诊的面部Ⅱ度烧伤患者36例，观察组(
n
=12)和对照组(
n
=12)患者通过随机抽样法进行分组，另有12例拒绝进行治疗的患者作为未处理组。观察组使用超声波(频率1 MHz，强度0.8 W/cm
2
，2次/d)导入维生素E(0.5~1 mL，2次/d)治疗面部色素沉着，2周为1个疗程；对照组仅外用涂抹维生素E；未处理组面部皮肤不做处理。3组患者面部皮肤均严格进行物理防晒，于治疗2、4周后观察疗效。
结果
2
治疗2周后，观察组总有效率为83.33%，高于对照组(66.67%)和未处理组(8.33%)，3组治疗总有效率差异有统计学意义(
P
=0.001)；治疗4周后，观察组和对照组总有效率均为83.33%，高于未处理组(25.00%)，3组治疗总有效率差异有统计学意义(
P
=0.011)。观察组患者治疗2、4周后色素面积和色素强度减轻程度均明显高于对照组和未处理组(
P
<
0.05)，对照组明显高于未处理组(
P
<
0.05)。随着时间的增加，3组患者色素面积和色素强度均呈减轻趋势，其中对照组治疗4周后患者色素面积和色素强度减轻程度明显高于2周(
P
<
0.05)，而观察组患者治疗2周即达到对照组治疗4周的效果(
P
>
0.05)。
结论
2
超声波导入维生素E可有效改善面部烧伤形成的炎症后色素沉着，缩短见效时间。
Abstract
Objective
2
To observe the therapeutic effect of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn.
Methods
2
All the 36 patients with facial second degree treated in our hospital between September 2019 and September 2020 were recruited in this study. Twenty-four of them were randomly assigned into the observation group (
n
=12) and the control group (
n
=12)
and the other 12 who refused treatment were automatically assigned to the blank control group (
n
=12). The observation group was treated with vitamin E (0.5~1 mL
twice per day) by sonophoresis (frequency 1 MHz
intensity 0.8 W/cm
2
twice per day)
while the control group was only treated with vitamin E
and the blank control group was not treated with vitamin E. And the 3 groups of patients followed strictly physical sunscreen for facial skin. After 2 and 4 weeks of treatment
the curative effects were observed and compared among the 3 groups.
Results
2
After 2 weeks
the total effective rate was 83.33% in the observation group
66.67% in the control group
and 8.33% in the blan
k control group; And significant difference in the rate was observed among the 3 groups (
P
=0.001). In 4 weeks after treatment
the total effective rate was 83.33% in both the observation group and the control group
obviously higher than that of the blank control group (25.00%
P
=0.011). The observation group obtained less pigment area and weaker pigment intensity when compared the other 2 groups in 2 and 4 weeks after treatment (
P
<
0.05)
and the conditions in the pigmentation were better in the control group than the blank control group (
P
<
0.05). With time elapsing
the pigment area and pigment intensity were in a trend of decreasing in all of the 3 groups. The conditions after 4 weeks' treatment were greatly improved than those at 2 weeks in the control group (
P
<
0.05). Those at 2 weeks in the observation group were similar to those in the control group after 4 weeks' treatment (
P
>
0.05).
Conclusion
2
Vitamin E though sonophoresis can effectively improve the postinflammatory hyperpigmentation and shorten the effective time for facial burn.
关键词
Keywords
references
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