北京市农村居民代谢综合征及其组分与动脉硬化的相关性研究

王紫荆; 武轶群; 吴瑶; 王梦莹; 王小文; 吴俊慧; 王斯悦; 王伽婷; 陈大方; 吴涛; 胡永华

doi:10.16016/j.1000-5404.202101015

您当前的位置：

首页 >

文章列表页 >

北京市农村居民代谢综合征及其组分与动脉硬化的相关性研究

专题报道：常见慢性非传染性疾病的预防与控制 | 更新时间：2026-01-09

- 北京市农村居民代谢综合征及其组分与动脉硬化的相关性研究
- Correlation of metabolic syndrome and its components with arterial stiffness among rural residents in Beijing
- 第三军医大学学报 2021年43卷第12期页码：1109-1116
- 作者机构：
  
  100191 北京，北京大学公共卫生学院流行病与卫生统计学系
- 作者简介：
  
  [胡永华，E-mail: yhhu@bjmu.edu.cn HU Yonghua, E-mail: yhhu@bjmu.edu.cn
- 基金信息：
  
  国家自然科学基金(81872695);国家自然科学基金(81703291)
- DOI：10.16016/j.1000-5404.202101015
  中图分类号： R181.3;R543.5;R589.9
- 收稿：2021-01-04，
  
  修回：2021-02-17，
  
  纸质出版：2021-06-30
- 稿件说明：
移动端阅览
王紫荆, 武轶群, 吴瑶, 等. 北京市农村居民代谢综合征及其组分与动脉硬化的相关性研究[J]. 第三军医大学学报, 2021,43(12):1109-1116.

Zijing WANG, Yiqun WU, Yao WU, et al. Correlation of metabolic syndrome and its components with arterial stiffness among rural residents in Beijing[J]. Journal of Third Military Medical University, 2021, 43(12): 1109-1116.
王紫荆, 武轶群, 吴瑶, 等. 北京市农村居民代谢综合征及其组分与动脉硬化的相关性研究[J]. 第三军医大学学报, 2021,43(12):1109-1116. DOI： 10.16016/j.1000-5404.202101015.

Zijing WANG, Yiqun WU, Yao WU, et al. Correlation of metabolic syndrome and its components with arterial stiffness among rural residents in Beijing[J]. Journal of Third Military Medical University, 2021, 43(12): 1109-1116. DOI： 10.16016/j.1000-5404.202101015.

摘要

目的

探讨代谢综合征(metabolism syndrome

MS)及其组分与动脉硬化的关系，并分析其性别差异。

方法

对6 737名北京市农村居民进行问卷调查、体格检查和血生化检测。MS定义采用中华医学会糖尿病学分会2017年修订版标准。动脉硬化定义为肱踝脉搏波传导速度≥1 700 cm/s。采用多因素Logistic回归分析MS及其组分与动脉硬化的相关性。

结果

研究对象中动脉硬化、MS患者占比分别为41.7%和64.4%。MS患者动脉硬化风险是非患者的2.36倍(95%

: 2.06~2.71)；除高密度脂蛋白胆固醇降低外，其余MS组分均与动脉硬化显著相关，相关性由大到小依次为高血压、高血糖、甘油三酯升高和中心性肥胖。MS与动脉硬化的相关性在女性中强于男性，差异有统计学意义(

=0.023)。

结论

MS与动脉硬化风险增加有关，高血压是影响最大的组分；MS对动脉硬化的影响在女性中更强。

Abstract

Objective

To investigate the correlation of metabolic syndrome (MS) and its components with arterial stiffness

and to analyze the gender difference.

Methods

Questionnaires

physical examinations and blood biochemical tests were conducted among 6 737 rural residents in Beijing. The diagnosis of MS is identified based on the 2017 modified standard of Diabetes Society of Chinese Medical Association

and arterial stiffness is defined as brachia-ankle pulse wave velocity (BAPWV) ≥1 700 cm/s. Multivariate Logistic regression analysis was used to analyze the correlation of MS and its components with arterial stiffness.

Results

In the subjects

arterial stiffness and MS patients accounted for 41.7% and 64.4%

respectively. The MS patients was at a risk of arterial stiffness by 2.36-fold (95%

: 2.06~2.71) higher than that in the non-MS subjects. Except for the reduced high density lipoprotein-cholesterol (HDL-C)

the other MS components were all significantly correlated with arterial stiffness

including elevated blood pressure

blood glucose and triglyceride

and central obesity. The correlation between MS and arterial stiffness was stronger in the women than the men.

Conclusion

MS is correlated with an increased risk of arterial stiffness

with elevated blood pressure being the most significant component. The effect of MS and its components on arterial stiffness is stronger in female population.

关键词

Keywords

references

Expert Panel on Detection E. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel Ⅲ)[J]. JAMA, 2001, 285(19): 2486-2497. DOI: 10.1001/jama.285.19.2486.

ECKEL R H, ALBERTI K G, GRUNDY S M, et al . The metabolic syndrome[J ] . Lancet, 2010, 375(9710): 181-183. DOI: 10.1016/s0140-6736(09)61794-3.

朱文华, 陈丽英, 卢崇蓉, 等. 代谢综合征组分异常积聚与肱踝动脉脉搏波传导速度的关系[J]. 中华心血管病杂志, 2018, 46(10): 810-817. DOI: 10.3760/cma.j.issn.0253-3758.2018.10.009.

ZHU W H, CHEN L Y, LU C R, et al . Association between the accumulation of metabolic syndrome abnormal components and arterial pulse wave velocity among adult individuals undergoing routine health examination[J ] . Chin J Cardiol, 2018, 46(10): 810-817. DOI: 10.3760/cma.j.issn.0253-3758.2018.10.009.

CUSPIDI C, SALA C, TADIC M, et al . Association of metabolic syndrome with carotid thickening and plaque in the general population: a meta-analysis[J ] . J Clin Hypertens (Greenwich), 2018, 20(1): 4-10. DOI: 10.1111/jch.13138.

STEHOUWER C D, HENRY R M, FERREIRA I. Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease[J]. Diabetologia, 2008, 51(4): 527-539. DOI: 10.1007/s00125-007-0918-3.

ALBERTI K G, ZIMMET P, SHAW J, et al . The metabolic syndrome: a new worldwide definition[J ] . Lancet, 2005, 366(9491): 1059-1062. DOI: 10.1016/S0140-6736(05)67402-8.

中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中华糖尿病杂志, 2018, 10(1): 4-67. DOI: 10.3760/cma.j.issn.1674-5809.2018.01.003.

Chinese Diabetes Society of Chinese Medical Association. Guidelines for the prevention and control of type 2 diabetes in China (2017 Edition)[J]. Chin J Diabetes Mellit, 2018, 10(1): 4-67. DOI: 10.3760/cma.j.issn.1674-5809.2018.01.003.

WANG A X, SU Z P, LIU X X, et al . Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study[J ] . BMC Cardiovasc Disord, 2016, 16(1): 1-10. DOI: 10.1186/s12872-016-0409-x.

TOMIYAMA H, HIRAYAMA Y, HASHIMOTO H, et al . The effects of changes in the metabolic syndrome detection status on arterial stiffening: a prospective study[J ] . Hypertens Res, 2006, 29(9): 673-678. DOI: 10.1291/hypres.29.673.

CHEN L, ZHU W, MAI L, et al . The association of metabolic syndrome a nd its components with brachial-ankle pulse wave velocity in South China[J ] . Atherosclerosis, 2015, 240(2): 345-350. DOI: 10.1016/j.atherosclerosis.2015.03.031.

KIM H L, LEE J M, SEO J B, et al . The effects of metabolic syndrome and its components on arterial stiffness in relation to gender[J ] . J Cardiol, 2015, 65(3): 243-249. DOI: 10.1016/j.jjcc.2014.05.009.

ZHANG L, YIN J K, DUAN Y Y, et al . Evaluation of carotid artery elasticity changes in patients with type 2 diabetes[J ] . Cardiovasc Diabetol, 2014, 13: 39. DOI: 10.1186/1475-2840-13-39.

YAMASHINA A, TOMIYAMA H, TAKEDA K, et al . Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement[J ] . Hypertens Res, 2002, 25(3): 359-364. DOI: 10.1291/hypres.25.359.

王梦莹, 唐迅, 秦雪英, 等. 北方农村地区居民常见慢性非传染性疾病的家系队列研究进展[J]. 中华流行病学杂志, 2018, 39(1): 94-97. DOI: 10.3760/cma.j.issn.0254-6450.2018.01.020.

WANG M Y, TANG X, QIN X Y, et al . Progress in research of family-based cohort study on common chronic non-communicable diseases in rural population in Northern China[J ] . Chin J Epidemiol, 2018, 39(1): 94-97. DOI: 10.3760/cma.j.issn.0254-6450.2018.01.020.

孙可欣, 刘志科, 曹亚英, 等. 北京某社区2型糖尿病患者血糖控制情况与肱踝脉搏波传导速度的相关性研究[J]. 北京大学学报(医学版), 2015, 47(3): 431-436.

SUN K X, LIU Z K, CAO Y Y, et al . Relationship between brachial-ankle pulse wave velocity and glycemic control of type 2 diabetes mellitus patients in Beijing community population[J ] . J Peking Univ Heal Sci, 2015, 47(3): 431-436.

黄哲, 许蓓蓓, 王小文, 等. 2型糖尿病患者肥胖状态与肱踝脉搏波传导速度的相关性[J]. 中华疾病控制杂志, 2019, 23(9): 1086-1091. DOI: 10.16462/j.cnki.zhjbkz.2019.09.014.

HUANG Z, XU B B, WANG X W, et al . Association of obesity and brachial-ankle pulse wave velocity among type 2 diabetes patients[J ] . Chin J Dis Control Prev, 2019, 23(9): 1086-1091. DOI: 10.16462/j.cnki.zhjbkz.2019.09.014.

TOMIYAMA H, KOJI Y, YAMBE M, et al . Brachial: ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome[J ] . Circ J, 2005, 69(7): 815-822. DOI: 10.1253/circj.69.815.

LI C I, KARDIA S L, LIU C S, et al . Metabolic syndrome is associated with change in subclinical arterial stiffness: a community-based Taichung community health study[J ] . BMC Public Health, 2011, 11: 808. DOI: 10.1186/1471-2458-11-808.

GOMEZ-SANCHEZ L, GARCIA-ORTIZ L, PATINO-ALONSO M C, et al . Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial[J ] . Cardiovasc Diabetol, 2016, 15(1): 148. DOI: 10.1186/s12933-016-0465-7.

SATOH H, KISHI R, TSUTSUI H. Metabolic syndrome is a significant and independent risk factor for increased arterial stiffness in Japanese subjects[J]. Hypertens Res, 2009, 32(12): 1067-1071. DOI: 10.1038/hr.2009.158.

FEENER E P, KING G L. Vascular dysfunction in diabetes mellitus[J]. Lancet, 1997, 350 (Suppl 1): SI9-S13. DOI: 10.1016/s0140-6736(97)90022-2.

KASHYAP S R, DEFRONZO R A. The insulin resistance syndrome: physiological considerations[J]. Diabetes Vasc Dis Res, 2007, 4(1): 13-19. DOI: 10.3132/dvdr.2007.001.

REAVEN G M. Banting lecture 1988. Role of insulin resistance in human disease[J]. Diabetes, 1988, 37(12): 1595-1607. DOI: 10.2337/diabetes.37.12.1595.

WENG C, YUAN H, TANG X, et al . Age- and gender- dependent association between components of metabolic syndrome and subclinical arterial stiffness in a Chinese population[J ] . Int J Med Sci, 2012, 9(8): 730-737. DOI: 10.7150/ijms.4752.

陆骆, 张婕, 李勉,等. 代谢综合征增加动脉硬化患病风险[J]. 内科理论与实践, 2012, 7(6): 443-447. DOI: 10.3969/j.issn.1673-6087.2012.06.012.

LU L, ZHANG J, LI M, et al . Metabolic syndrome associated with increased risk of arteriosclerosis[J ] . J Intern Med Concepts Pract, 2012, 7(6): 443-447. DOI: 10.3969/j.issn.1673-6087.2012.06.012.

KASS D A. Ventricular arterial stiffening: integrating the pathophysiology[J]. Hypertension, 2005, 46(1): 185-193. DOI: 10.1161/01.hyp.0000168053.34306.d4.

林旻洁, 赵水平. 甘油三酯与冠心病发病关系及机制的研究进展[J]. 中国动脉硬化杂志, 2011, 19(12): 1043-1046.

LIN M J, ZHAO S P. Advances in the relationship between triglycerides and coronary heart disease[J]. Chin J Arterioscler, 2011, 19(12): 1043-1046.

ROSENSON R S, BREWER H B, CHAPMAN M J, et al . HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events[J ] . Clin Chem, 2011, 57(3): 392-410. DOI: 10.1373/clinchem.2010.1553 33.

KHERA A V, CUCHEL M, DE LA LLERA-MOYA M, et al . Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis[J ] . N Engl J Med, 2011, 364(2): 127-135. DOI: 10.1056/nejmoa1001689.

CHEI C L, YAMAGISHI K, KITAMURA A, et al . High-density lipoprotein subclasses and risk of stroke and its subtypes in Japanese population: the circulatory risk in communities study[J ] . Stroke, 2013, 44(2): 327-333. DOI: 10.1161/STROKEAHA.112.674812.

李亮亮. 代谢综合征颈动脉内中膜厚度变化的探讨[J]. 医学信息, 2015(23): 380. DOI: 10.3969/j.issn.1006-1959.2015.23.588.

LI L L. Study on the change of carotid intimal thickness in metabolic syndrome[J]. Med Inf, 2015(23): 380. DOI: 10.3969/j.issn.1006-1959.2015.23.588.

PRADHAN A D. Sex differences in the metabolic syndrome: implications for cardiovascular health in women[J]. Clin Chem, 2014, 60(1): 44-52. DOI: 10.1373/clinchem.2013.202549.

LI C, FORD E S, LI B, et al . Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men[J ] . D iabetes Care,2010, 33(7): 1618-1624. DOI: 10.2337/dc09-1788.

CORDERO A, ALEGRIA E. Sex differences and cardiovascular risk[J]. Heart, 2006, 92(2): 145-146. DOI: 10.1136/hrt.2005.069187.

REGITZ-ZAGROSEK V, LEHMKUHL E, MAHMOODZADEH S. Gender aspects of the role of the metabolic syndrome as a risk factor for cardiovascular disease[J]. Gend Med, 2007, 4(Suppl B): S162-S177. DOI: 10.1016/s1550-8579(07)80056-8.

LIEBER A, MILLASSEAU S, BOURHIS L, et al . Aortic wave reflection in women and men[J ] . Am J Physiol Heart Circ Physiol, 2010, 299(1): H236-H242. DOI: 10.1152/ajpheart.00985.2009.

张林峰, 王增武, 陈祚, 等. 我国人群主要心血管病危险因素1982-2010年的变化[J]. 医学研究杂志, 2019, 48(3): 39-44.

ZHANG L F, WANG Z W, CHEN Z, et al . Secular trends of major cardiovascular risk factors in middle-aged Chinese during the period of 1982 to 2010[J ] . J Med Res, 2019, 48(3): 39-44.

NIELSEN S, GUO Z, JOHNSON C M, et al . Splanchnic lipolysis in human obesity[J ] . J Clin Invest, 2004, 113(11): 1582-1588. DOI: 10.1172/jci21047.

WENG C Y, YUAN H, YANG K, et al . Gender-specific association between the metabolic syndrome and arterial stiffness in 8, 300 subjects[J ] . Am J Med Sci, 2013, 346(4): 289-294. DOI: 10.1097/MAJ.0b013e3182732e97.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

代谢综合征相关认知障碍的潜在机制：促甲状腺激素在精神分裂症患者中的中介效应

血液灌流对代谢综合征患者血脂、血压的影响及其机制研究

军队干部疗养员运动情况与代谢综合征危险因素的调查研究

组织特异性胰岛素抵抗及其代谢综合征的机制探讨

重庆市成人血尿酸水平与代谢综合征相关因素分析