纳布啡复合丙泊酚用于小儿无痛结肠镜检查的临床研究

刘阳; 唐文; 徐颖; 崔洁; 张甜歌; 彭银俊丞

doi:10.16016/j.1000-5404.202012242

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纳布啡复合丙泊酚用于小儿无痛结肠镜检查的临床研究

临床医学 | 更新时间：2026-01-09

- 纳布啡复合丙泊酚用于小儿无痛结肠镜检查的临床研究
- Nalbuphine combined with propofol for painless colonoscopy: report of 90 3- to 6-year-old children
- 第三军医大学学报 2021年43卷第13期页码：1269-1274
- 作者机构：
  
  400010 重庆，重庆医科大学附属儿童医院麻醉科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿科学重庆市重点实验室
- 作者简介：
  
  [唐文, E-mail: tangwen1110@163.comTANG Wen, E-mail: tangwen1110@163.com
- 基金信息：
  
  重庆市科技计划项目(CSTC2018jscx-msybX0104)
- DOI：10.16016/j.1000-5404.202012242
  中图分类号： R725.746.2;R969.4;R971.2
- 收稿：2020-12-30，
  
  修回：2021-02-14，
  
  纸质出版：2021-07-15
- 稿件说明：
移动端阅览
刘阳, 唐文, 徐颖, 等. 纳布啡复合丙泊酚用于小儿无痛结肠镜检查的临床研究[J]. 第三军医大学学报, 2021,43(13):1269-1274.

Yang LIU, Wen TANG, Ying XU, et al. Nalbuphine combined with propofol for painless colonoscopy: report of 90 3- to 6-year-old children[J]. Journal of Third Military Medical University, 2021, 43(13): 1269-1274.
刘阳, 唐文, 徐颖, 等. 纳布啡复合丙泊酚用于小儿无痛结肠镜检查的临床研究[J]. 第三军医大学学报, 2021,43(13):1269-1274. DOI： 10.16016/j.1000-5404.202012242.

Yang LIU, Wen TANG, Ying XU, et al. Nalbuphine combined with propofol for painless colonoscopy: report of 90 3- to 6-year-old children[J]. Journal of Third Military Medical University, 2021, 43(13): 1269-1274. DOI： 10.16016/j.1000-5404.202012242.

摘要

目的

观察纳布啡复合丙泊酚用于小儿无痛结肠镜检查的有效性及安全性。

方法

选取2020年5月至2020年10月来本院行无痛结肠镜检查3~6岁患儿90例，采用随机、单盲、对照的方法，通过随机数字表法将其分为2组，每组45例，分别为纳布啡组: 纳布啡0.3 mg/kg静脉复合丙泊酚3 mg/kg；舒芬太尼组: 舒芬太尼0.2 μg/kg静脉复合丙泊酚3 mg/kg。根据肠镜检查步骤，观察两组患儿在各个时间点的生命体征变化，记录诱导时间(induction time，IT)、检查时间(total scan time，ST)、苏醒时间(recovery time，RT)、镇痛效果和不良反应发生率。

结果

两组患儿性别、年龄、体质量、ASA分级、操作类型和息肉数量差异无统计学意义；镇痛剂给药后3 min(T

)两组患儿的生命体征均较给药前即刻(T

)降低(

0.05);纳

布啡组T

时的呼吸频率(respiratory rate

RR)和血氧饱和度(SpO

)高于舒芬太尼组(

0.05)，其苏醒时间较舒芬太尼组明显缩短(

0.01);两组患儿镇痛效果差异无统计学意义；纳布啡组患儿未出现不良反应，舒芬太尼组5例呛咳，两组患儿均未发生严重并发症。

结论

纳布啡复合丙泊酚用于小儿无痛结肠镜检查镇静镇痛效果好，对呼吸影响小，不良反应发生率低且苏醒快。

Abstract

Objective

To observe the effectiveness and safety of nalbuphine combined with propofol in children with painless colonoscopy.

Methods

A total of 90 children aged 3 to 6 years from the Children's Hospital of Chongqing Medical University who underwent painless colonoscopy from May to October 2020 were recruited

and then randomly divided into nalbuphine group (N group

=45

0.3 mg/kg nalbuphine injected intravenously with combination of 3 mg/kg propofol) and sufentanil group (S group

=45

0.2 μg/kg sufentanil injected intravenously with combination of 3 mg/kg propofol). According to the procedure of colonoscopy

the changes in vital signs were observed in the 2 groups of children at various time points. Induction time (IT)

examination time (total scan time

ST)

recovery time (RT)

analgesic effect and incidence of adverse reactions were also recorded.

Results

There were no statistical differences in gender

age

body weight

status of American Society of Anesthesiologists (ASA) classification

operation type and number of polyps between the 2 groups (

0.05). The vital signs were significantly lower in the 2 groups in 3 min after the analgesic administration (T

) than immediately before the administration (T

) (

0.05). The N group had obviously higher respiratory rate (

0.05) and oxygen saturation at T

(

0.05)

but shorter recovery time when compared with the S group (

0.01). Ho

wever

there was no notable difference in the analgesic effect between the 2 groups. No adverse reactions were observed in the N group

and coughing was seen in 5 cases of the S group. No serious complications occurred in the 2 groups.

Conclusion

Nalbuphine combined with propofol has good sedative and analgesic effects in painless colonoscopy for children

with little impact on breathing

low incidence of adverse reactions and quick recovery.

关键词

Keywords

references

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