急性心肌梗死患者血浆的脂质代谢特征与潜在生物标志物研究

茹文鑫; 胡汉; 周婷; 韩颖; 杨清; 高玉霞

doi:10.16016/j.1000-5404.202011212

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急性心肌梗死患者血浆的脂质代谢特征与潜在生物标志物研究

临床医学 | 更新时间：2026-01-09

- 急性心肌梗死患者血浆的脂质代谢特征与潜在生物标志物研究
- Characteristics of plasma lipid metabolism and potential biomarkers in patients with acute myocardial infarction
- 第三军医大学学报 2021年43卷第10期页码：970-981
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202011212
  中图分类号：
- 收稿：2020-11-22，
  
  纸质出版：2021-05-30
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茹文鑫, 胡汉, 周婷, 等. 急性心肌梗死患者血浆的脂质代谢特征与潜在生物标志物研究[J]. 第三军医大学学报, 2021,43(10):970-981.

Wenxin RU, Han HU, Ting ZHOU, et al. Characteristics of plasma lipid metabolism and potential biomarkers in patients with acute myocardial infarction[J]. Journal of Third Military Medical University, 2021, 43(10): 970-981.
茹文鑫, 胡汉, 周婷, 等. 急性心肌梗死患者血浆的脂质代谢特征与潜在生物标志物研究[J]. 第三军医大学学报, 2021,43(10):970-981. DOI： 10.16016/j.1000-5404.202011212.

Wenxin RU, Han HU, Ting ZHOU, et al. Characteristics of plasma lipid metabolism and potential biomarkers in patients with acute myocardial infarction[J]. Journal of Third Military Medical University, 2021, 43(10): 970-981. DOI： 10.16016/j.1000-5404.202011212.

摘要

Abstract

Objective

To compare the differences in plasma lipid metabolites between the patients with acute myocardial infarction (AMI) and those with normal coronary artery in order to explore the pathophysiologic mechanism and search for possible new biomarkers of AMI.

Methods

The patients undergoing coronary angiography in our hospital from September 20

2019 to January 20

2020 were enrolled in this study. According to the results

they were divided into myocardial infarction group (AMI group

=32) and control group (age- and sex-matched with the AMI group

=32). Non-targeted lipidomics analysis was performed on the blood samples to find the differences of lipid metabolites betw

een the 2 groups. Univariate and multivariate statistical analyses were applied to explore the meaningful differential metabolites

and receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the selected differential metabolites. Finally

how to disturb metabolic pathways was investigated in the AMI patients.

Results

① The orthogonal projection to latent structure discriminant analysis (OPLS-DA) and cluster heat map showed that there was a significant trend of separation between AMI group and the control group. Multivariate statistical analysis identified totally 28 differential plasma lipid metabolites

including 16 of them significantly increased and 12 decreased in the AMI group. ②There were 10 lipid metabolites such as diglyceride (DG) and phosphatidyl serine (PS) associated with an increased risk of AMI

while 13 negative predictors

including phosphatidylinositol (PI)

phosphatidylcholine (PC)

phosphatidylserine (PS)

lytic phosphatidylcholine (LPC) and triglyceride (TG)

were associated with a reduced risk of AMI. ③ROC curve identified 2 possible biomarkers of AMI

namely

PS (27∶0) (AUC=0.976) and DG(16∶0/18∶1) (AUC=0.807); ④The disturbed metabolic pathways included metabolism of glycerol phospholipid

sphingomyelin

purine and pyrimidine in the AMI patients

among which the disorder of glycerophospholipid metabolism was the most signficant.

Conclusion

The characteristics of lipid metabolism are significantly changed in AMI patients; a total of 28 differential lipid metabolites are identified

among which the disorder of glycerol phospholipid metabolism pathway indicates the most significant. PS and DG may act as the potential biomarkers for the diagnosis of AMI.

关键词

Keywords

references

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